INT84732

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 81
Total Number 83
Disease Relevance 62.07
Pain Relevance 22.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
T cells 5
lymphocyte 4
lung 3
macrophages 2
Th1 cells 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2065 100.00 Very High Very High Very High
cytokine 2015 100.00 Very High Very High Very High
withdrawal 65 100.00 Very High Very High Very High
agonist 236 99.98 Very High Very High Very High
Morphine 47 99.98 Very High Very High Very High
rheumatoid arthritis 235 99.92 Very High Very High Very High
Cannabinoid 118 99.80 Very High Very High Very High
Endogenous opioid 1 99.54 Very High Very High Very High
Inflammatory response 143 99.28 Very High Very High Very High
antagonist 398 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2187 100.00 Very High Very High Very High
Hypersensitivity 662 100.00 Very High Very High Very High
Hyperplasia 167 100.00 Very High Very High Very High
Sprains And Strains 593 99.98 Very High Very High Very High
Asthma 3533 99.96 Very High Very High Very High
Rheumatoid Arthritis 258 99.92 Very High Very High Very High
Common Cold 85 99.92 Very High Very High Very High
Candida Infection 686 99.90 Very High Very High Very High
Eosinophilia 209 99.90 Very High Very High Very High
Stroke 19 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was determined that 24-h morphine withdrawal resulted in a decrease in IFN-gamma, the Th1 signature cytokine, whereas the Th2 cytokine, IL-4, was increased.
Positive_regulation (increased) of Th2 associated with withdrawal, cytokine and morphine
1) Confidence 0.69 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.40
We had previously shown that chronic morphine treatment in vivo and in vitro decreases IL-2 and IFNgamma (Th1) protein levels and increases IL-4 and IL-5 (Th2) protein levels in a time-dependent manner.
Positive_regulation (increases) of Th2 associated with morphine
2) Confidence 0.52 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.54
In addition, Western blot and EMSA experiments revealed that morphine withdrawal-induced Th2 differentiation was mediated through the classical Th2 transcription factors Stat-6 and GATA-3.
Positive_regulation (mediated) of Th2 associated with withdrawal and morphine
3) Confidence 0.50 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.41
The effect of naloxone could be ascribed to the removal of the regulatory effects exerted by endogenous opioid peptides, which could activate Th2 and suppress Th1 cytokines.
Positive_regulation (activate) of Th2 associated with endogenous opioid, narcan and cytokine
4) Confidence 0.44 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.09 Pain Relevance 0.82
In addition, Western blot and EMSA experiments revealed that morphine withdrawal-induced Th2 differentiation was mediated through the classical Th2 transcription factors Stat-6 and GATA-3.
Positive_regulation (mediated) of Th2 associated with withdrawal and morphine
5) Confidence 0.43 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.41
In addition, Western blot and EMSA experiments revealed that morphine withdrawal-induced Th2 differentiation was mediated through the classical Th2 transcription factors Stat-6 and GATA-3.
Positive_regulation (withdrawal-induced) of Th2 associated with withdrawal and morphine
6) Confidence 0.43 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.40
Lymphocytes from these mice could be driven into a Th2 phenotype, suggesting that cultures containing IL-4 do not require PPNK for Th2 differentiation.
Neg (not) Positive_regulation (require) of Th2 in Lymphocytes
7) Confidence 0.41 Published 1999 Journal Immunol. Cell Biol. Section Abstract Doc Link 10540203 Disease Relevance 0 Pain Relevance 0.34
Th2 cytokines (IL-4, IL-13) were significantly increased from 4 h to day 7. 5-HT-expressing cells in the intestine were increased from day 1 to day 7.
Positive_regulation (increased) of Th2 in intestine
8) Confidence 0.38 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 19735478 Disease Relevance 0.07 Pain Relevance 0
WT mice challenged with OVA showed significant increases in Th2 cytokines.
Positive_regulation (increases) of Th2 associated with cytokine
9) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0 Pain Relevance 0.24
Th2 cytokine induction and total IgE in airways by all transretinoic acid
Positive_regulation (induction) of Th2 associated with cytokine
10) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.45 Pain Relevance 0.14
The adverse outcomes include decreased birth weight, decreased cord blood cytokines levels (both TH1 and TH2), increased collagen deposition in airway and alveolar walls, abnormal lung function at birth, and suppressed ventilatory responses to postnatal hypoxia (Sekhon et al. 2002; Ueda et al. 1999).
Positive_regulation (increased) of TH2 in lung associated with birth weight, hypoxia and cytokine
11) Confidence 0.30 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.04 Pain Relevance 0.22
Some dendritic cells are more likely to induce Th1 type immune responses whereas macrophage cells induce Th2 type responses affecting the pattern of antibody isotypes [46].
Positive_regulation (induce) of Th2 in macrophage
12) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.52 Pain Relevance 0
pyrimidines, work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner [56].Dong et al. [57] reported that synthetic ODN delay the onset of glomerulonephritis and prolong survival in lupus-prone B/WF1 mice, which is one of excellent mouse models for human lupus (Figure 3) with a significant reduction in productions of anti-dsDNA autoantibody, IFN-?
Positive_regulation (induction) of Th2 associated with renal disease and systemic lupus erythematosus
13) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.84 Pain Relevance 0.17
Children with ASD have increased cytokines of Th2 and Th1 arms of the immune response with Th2 predominant without an increase in IL10 [13].
Positive_regulation (increased) of Th2 in arms associated with cytokine
14) Confidence 0.27 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.99 Pain Relevance 0.36
In our model it appears that the particles which induced cellular responses in the absence of allergen (i.e. ambient air particles in BALB/cA mice [47] as well as PSP in NIH and C3H/HeN mice (present study)) enhanced both Th2- and Th1-associated antibody responses, whereas the particles enhancing a Th2-dominated antibody response (i.e.
Positive_regulation (enhanced) of Th2 in PSP
15) Confidence 0.26 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.23 Pain Relevance 0.07
Noteworthy, nevertheless, is the observation that the early and prominent increase in Th2 transcripts was short-lived (Figure 3) and did not culminate in production of measurable cytokines in vivo (Figure 5).
Positive_regulation (increase) of Th2 associated with cytokine
16) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.84 Pain Relevance 0.15
In the present study, the antibody adjuvant effect of PSP differed between the different strains of mice, both with regard to the magnitude and whether a Th2 or a mixed Th1- and Th2-associated antibody response was increased.
Positive_regulation (increased) of Th2 in PSP associated with sprains and strains
17) Confidence 0.25 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.69 Pain Relevance 0
Hence, also patients suffering from allergic asthma displayed mixed T helper cell responses, reflected by the occurrence of TH2 specific IL-13 and of TH1 specific IFN-?
Positive_regulation (occurrence) of TH2 associated with asthma
18) Confidence 0.24 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.65 Pain Relevance 0.12
Thus, a shift in immune responses with a downregulation of Th1 and an upregulation of Th2 is thought to be necessary for fetal survival [10,103-105].
Positive_regulation (upregulation) of Th2
19) Confidence 0.24 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.71 Pain Relevance 0.15
This effect on Th2 cytokines, via a modulation of Th2 activation, may result from a role of H4R in the Th2 priming capability of dendritic cells [6].
Positive_regulation (activation) of Th2 in dendritic cells associated with cytokine
20) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.32 Pain Relevance 0.41

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