INT84749

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Context Info
Confidence 0.73
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.84
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A) signal transduction (PDE2A) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) plasma membrane (PDE2A) nucleus (PDE2A)
Anatomy Link Frequency
endothelial cells 3
PDE2A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 97.60 Very High Very High Very High
cINOD 1 72.48 Quite High
withdrawal 2 50.00 Quite Low
Clonidine 1 50.00 Quite Low
Morphine 1 50.00 Quite Low
headache 6 25.00 Low Low
Opioid 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 5 98.48 Very High Very High Very High
Death 2 95.64 Very High Very High Very High
Apoptosis 2 93.12 High High
Solid Tumor 1 78.08 Quite High
INFLAMMATION 1 72.28 Quite High
Opiate Addiction 1 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Real time polymerase chain reaction and Western blots were used to show expression of PDE2A, PDE3B, and PDE5A in a stable cell line of human brain microvascular endothelial cells.
Gene_expression (expression) of PDE2A in endothelial cells
1) Confidence 0.73 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate nitric oxide (NO)-mediated changes in expression of cyclic nucleotide degrading phosphodiesterases 2A (PDE2A), PDE3B, and PDE5A in human endothelial cells.
Gene_expression (expression) of PDE2A in endothelial cells
2) Confidence 0.56 Published 2010 Journal Headache Section Abstract Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
RESULTS: This study shows the expression of PDE2A, PDE3B, and PDE5A mRNA and PDE3B and PDE5A protein in human cerebral endothelial cells.
Gene_expression (expression) of PDE2A in endothelial cells
3) Confidence 0.56 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
Accumulation of intracellular cGMP produced by an exogenous cell-permeant analogue of cGMP or a potent agonist of guanylyl cyclase C yielded cytostasis without cell death.
Gene_expression (produced) of cGMP associated with agonist and death
4) Confidence 0.15 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.76 Pain Relevance 0.12
Immune status was assessed by determining concanavalin A (Con-A), toxic shock syndrome toxin (TSST-1), and lipopolysaccharide (LPS)-stimulated splenocyte proliferation, splenic ConA-stimulated interferon (IFN)-gamma production, and splenic natural-killer (NK) cell activity.
Gene_expression (production) of ConA-stimulated
5) Confidence 0.00 Published 1999 Journal Psychopharmacology (Berl.) Section Body Doc Link 10541733 Disease Relevance 0.07 Pain Relevance 0

General Comments

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