INT8475

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 1997
Negated 3
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 1.36
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COLQ)
Anatomy Link Frequency
artery 1
Purkinje fibers 1
heart 1
COLQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 27 99.90 Very High Very High Very High
lidocaine 12 99.40 Very High Very High Very High
tetrodotoxin 17 99.18 Very High Very High Very High
addiction 2 98.88 Very High Very High Very High
abdominal pain 1 92.40 High High
agonist 1 78.48 Quite High
antagonist 1 76.68 Quite High
action potential duration 2 25.12 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 1 99.82 Very High Very High Very High
Anaemia 1 92.84 High High
Abdominal Pain 1 92.40 High High
Fever 1 91.76 High High
Ventricular Tachycardia 11 82.40 Quite High
Metastasis 1 76.12 Quite High
Stomach Cancer 1 75.24 Quite High
Dislocations 2 75.00 Quite High
Arrhythmia Under Development 2 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tetrodotoxin, lidocaine and nifedipine inhibited the induction of EAD.
Positive_regulation (induction) of EAD associated with tetrodotoxin and lidocaine
1) Confidence 0.45 Published 1990 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2093134 Disease Relevance 0 Pain Relevance 0.28
As the cycle length was prolonged (from 0.5-10 sec), EAD could be induced in 10 of 16 preparations showing exponential relationship with the cycle length.
Positive_regulation (induced) of EAD
2) Confidence 0.45 Published 1990 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2093134 Disease Relevance 0 Pain Relevance 0.27
On the other hand, the addition of 4 micro M verapamil abolished the strontium (0.5 mM)-induced EAD but did not abolish the AP.It is concluded that under conditions when the AP is not abolished, EAD blockade by lidocaine is less effective than that by verapamil.
Neg (not) Positive_regulation (induced) of EAD associated with action potential and lidocaine
3) Confidence 0.40 Published 1991 Journal J Anesth Section Abstract Doc Link 15278621 Disease Relevance 0 Pain Relevance 0.66
In conclusion, it was strongly suggested that arterial destruction due to the toxicity of 5-FU caused EAD in hepatic arterial infusion chemotherapy, especially in cases of cannulation via gastroduodenal artery due to the high concentration of 5-FU in a limited part of the arterial wall.
Positive_regulation (caused) of EAD in artery associated with toxicity
4) Confidence 0.40 Published 1997 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 9382544 Disease Relevance 0.67 Pain Relevance 0.09
In some preparations, EAD could not be induced, especially at a shorter cycle length, leaving a definite second plateau following the AP under treatment with effective agents.
Neg (not) Positive_regulation (induced) of EAD associated with action potential
5) Confidence 0.36 Published 1991 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 1711140 Disease Relevance 0 Pain Relevance 0.20
The effects of ryanodine on the action potential and induction of early afterdepolarization (EAD) were studied in the atrial fibers of mouse heart.
Positive_regulation (induction) of EAD in heart associated with action potential
6) Confidence 0.30 Published 1990 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2093134 Disease Relevance 0 Pain Relevance 0.22
In 6 preparations in which the EAD was not induced, more than one burst could respond to a single premature stimulation applied in the early phase of repolarization, which was defined as second plateau response.
Neg (not) Positive_regulation (induced) of EAD
7) Confidence 0.30 Published 1990 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2093134 Disease Relevance 0 Pain Relevance 0.27
The mechanism of ryanodine-induced EAD has been investigated.
Positive_regulation (induced) of EAD
8) Confidence 0.30 Published 1990 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2093134 Disease Relevance 0 Pain Relevance 0.25
The voltage-dependence of availability of the inward current transient and of EAD induction were similar.
Positive_regulation (induction) of EAD associated with addiction
9) Confidence 0.22 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2468430 Disease Relevance 0 Pain Relevance 0.48
Thus, EAD can be induced by different ionic mechanisms depending on the basal conditions.
Positive_regulation (induced) of EAD
10) Confidence 0.08 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1373273 Disease Relevance 0 Pain Relevance 0.21
EAD induced by aconitine always appeared first in Purkinje fibers and later in muscle fibers.
Positive_regulation (induced) of EAD in Purkinje fibers
11) Confidence 0.07 Published 1994 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7532749 Disease Relevance 0.63 Pain Relevance 0.20
These results indicate that veratridine-induced EAD is mainly formed by altered properties of the Na+ channel current and partly by the L-type Ca2+ current due to slowed repolarization.
Positive_regulation (induced) of EAD
12) Confidence 0.05 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1373273 Disease Relevance 0 Pain Relevance 0.23
The ventricular premature (VP) resulted from EAD triggered by CsCl.
Positive_regulation (triggered) of EAD
13) Confidence 0.05 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 8701770 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: The depressant effects of Tau and Tet on EAD and VP induced by CsCl were involved in an increase of outward current or a decrease of an inward current.


Positive_regulation (induced) of EAD
14) Confidence 0.05 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 8701770 Disease Relevance 0 Pain Relevance 0

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