INT84750

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DSP) structural molecule activity (DSP) plasma membrane (DSP)
protein binding, bridging (DSP) cytoplasm (DSP)
DSP (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 95.92 Very High Very High Very High
headache 1 62.16 Quite High
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 4 77.88 Quite High
Bullous Skin Disease 304 71.60 Quite High
Headache 1 62.16 Quite High
Pharyngitis 1 61.36 Quite High
Candida Infection 1 60.08 Quite High
Disease 18 44.16 Quite Low
Darier's Disease 1 43.76 Quite Low
Adhesions 51 11.92 Low Low
Acantholysis 65 5.00 Very Low Very Low Very Low
Apoptosis 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This can be concluded from experiments in which expression of N-terminally deleted Dsc 3 or desmoplakin deficiency resulted in impaired formation of both desmosomes and adherens junctions (Hanakawa et al. 2000; Vasioukhin et al. 2001).


Negative_regulation (deficiency) of Gene_expression (expression) of desmoplakin
1) Confidence 0.42 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.07 Pain Relevance 0.05
A consistent trend was observed for better improvement in patients treated with MF DPI 200 mcg b.i.d. than with MF DPI 100 mcg b.i.d., with no apparent additional benefit of MF DPI 400 mcg b.i.d.
Neg (no) Negative_regulation (benefit) of Gene_expression (b.i.d.) of DPI
2) Confidence 0.19 Published 1999 Journal Respir Med Section Abstract Doc Link 10542973 Disease Relevance 0.34 Pain Relevance 0.06

General Comments

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