INT8476

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Context Info
Confidence 0.37
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.38
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) extracellular region (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
plasma 1
nerve 1
Bche (Mus musculus)
Pain Link Frequency Relevance Heat
peptic ulcer disease 3 98.48 Very High Very High Very High
withdrawal 5 98.26 Very High Very High Very High
Analgesic 4 98.22 Very High Very High Very High
opiate 1 97.72 Very High Very High Very High
narcan 2 96.48 Very High Very High Very High
Opioid 2 94.28 High High
antidepressant 10 93.36 High High
antagonist 5 90.48 High High
anesthesia 11 86.80 High High
cINOD 118 86.76 High High
Disease Link Frequency Relevance Heat
Syndrome 17 99.52 Very High Very High Very High
Adverse Drug Reaction 26 98.68 Very High Very High Very High
Targeted Disruption 182 98.56 Very High Very High Very High
Convulsion 3 98.50 Very High Very High Very High
Ulcers 4 98.48 Very High Very High Very High
Disease 477 97.96 Very High Very High Very High
Alzheimer's Dementia 35 97.92 Very High Very High Very High
Pressure Volume 2 Under Development 5 95.80 Very High Very High Very High
Hemolysis 1 95.72 Very High Very High Very High
Sleep Disorders 4 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pseudocholinesterase deficiency associated with HELLP syndrome.
Pseudocholinesterase Binding (associated) of associated with syndrome
1) Confidence 0.37 Published 2004 Journal Am J Perinatol Section Title Doc Link 15311366 Disease Relevance 0.38 Pain Relevance 0.09
Serum cholinesterase /ChE/ investigation in children with gastroduodenitis or peptic ulcer disease indicate its low activity, specially in children with peptic ulcer disease.
Serum cholinesterase Binding (investigation) of associated with peptic ulcer disease and disease
2) Confidence 0.33 Published 1997 Journal Rocz. Akad. Med. Bialymst. Section Abstract Doc Link 9581484 Disease Relevance 0.54 Pain Relevance 0.27
Predisposition to nitrous oxide withdrawal convulsions as judged by duration of susceptibility was decreased significantly after pretreatment with the cholinesterase inhibitors, physostigmine and galanthamine, or with the opiate receptor blocking agent naloxone.
cholinesterase Binding (pretreatment) of associated with convulsion, narcan, opiate and withdrawal
3) Confidence 0.32 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6683088 Disease Relevance 0.26 Pain Relevance 0.36
BChE: butyrylcholinesterase; FVB: friend virus B-type; hSA: human serum albumin; huBChE: human butyrylcholinesterase; OP: organophosphorus compounds.


BChE Binding (compounds) of
4) Confidence 0.19 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.45 Pain Relevance 0
The two blunt-ended fragments were ligated to generate bCN/BChE/hSA for pronuclear microinjection to produce transgenic mice.
BChE Binding (generate) of associated with targeted disruption
5) Confidence 0.19 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.42 Pain Relevance 0
The main objective of this study was to examine if the fusion of huBChE and hSA would act in a manner to yield a novel protein that retains the recombinant BChE's binding and inhibition against OP nerve agents and the slow clearance of hSA.
BChE Binding (binding) of in nerve
6) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.23 Pain Relevance 0
-amyloid formation, at least in the case of some AChEIs (eg, phenserine), does not appear to be associated with cholinesterase inhibition but with a novel mechanism regulating translation of APP mRNA by a putative interleukin-1 or TGF-?
cholinesterase Neg (inhibition) Binding (inhibition) of associated with alzheimer's dementia
7) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.89 Pain Relevance 0.03
-blockers, class I antiarrhythmics, analgesics and many other drug categories, acting as substrates, inhibitors or inducers with which cholinesterase inhibitors may potentially interact, this leading to the outcome of ADRs (Cacabelos 2005a, b).
cholinesterase Binding (interact) of associated with adverse drug reaction and analgesic
8) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.25 Pain Relevance 0.24
Mivacurium is metabolized by plasma cholinesterase.
plasma cholinesterase Binding (metabolized) of in plasma
9) Confidence 0.12 Published 1992 Journal J Clin Anesth Section Abstract Doc Link 1373287 Disease Relevance 0.10 Pain Relevance 0.18
Cholinesterase inhibitors have consistently shown symptomatic benefits and are now recognized as the standard treatments in patients with mild-to-moderate AD (Doody, 2008).
Cholinesterase Binding (recognized) of associated with disease
10) Confidence 0.04 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.86 Pain Relevance 0.13

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