INT84765

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 5.95
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
epidermis 3
macrophages 2
melanocytes 2
monocytes 1
tail 1
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 291 100.00 Very High Very High Very High
cytokine 37 100.00 Very High Very High Very High
Inflammation 208 99.48 Very High Very High Very High
agonist 58 92.80 High High
antagonist 13 81.16 Quite High
ischemia 14 80.32 Quite High
chemokine 33 59.88 Quite High
adenocard 6 59.08 Quite High
Inflammatory response 14 52.40 Quite High
Neuropeptide 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 235 99.48 Very High Very High Very High
Stress 37 99.36 Very High Very High Very High
Sprains And Strains 21 98.72 Very High Very High Very High
Apoptosis 33 98.64 Very High Very High Very High
Skin Cancer 314 98.00 Very High Very High Very High
Colitis 8 97.28 Very High Very High Very High
Stomach Cancer 3 96.12 Very High Very High Very High
Cancer 177 90.88 High High
Urological Neuroanatomy 8 86.24 High High
Metastasis 37 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In D10 cells, however, up-regulation could not be reproduced in vivo, suggesting that MC1R up-regulation is more dependent on the physiological environment.
Positive_regulation (up-regulation) of MC1R associated with melanocortin 1 receptor
1) Confidence 0.70 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503610 Disease Relevance 0.33 Pain Relevance 0.86
A library of 951 compounds based upon the beta-turn motif were examined for their ability to stimulate the melanocortin-1 receptor.
Spec (examined) Positive_regulation (stimulate) of melanocortin-1 receptor associated with melanocortin 1 receptor
2) Confidence 0.69 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10543881 Disease Relevance 0 Pain Relevance 0.22
Additionally, these compounds represent the first nonpeptidic heterocyclic molecules reported to date that are able to activate the MC1R, a melanocyte receptor involved in skin pigmentation and animal coat coloration.
Positive_regulation (activate) of MC1R in skin
3) Confidence 0.69 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10543881 Disease Relevance 0 Pain Relevance 0.18
Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential.
Positive_regulation (Upregulation) of melanocortin-1 receptor in macrophage associated with melanocortin 1 receptor and skin cancer
4) Confidence 0.61 Published 1999 Journal Pigment Cell Res. Section Title Doc Link 10614575 Disease Relevance 0.50 Pain Relevance 0.17
Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn.
Positive_regulation (activate) of melanocortin-1 receptor associated with melanocortin 1 receptor
5) Confidence 0.60 Published 1999 Journal J. Med. Chem. Section Title Doc Link 10543881 Disease Relevance 0 Pain Relevance 0.24
-MSH are mediated through binding to and activation of MC-1R [18], [19].
Positive_regulation (activation) of MC-1R
6) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.41 Pain Relevance 0.17
Ultraviolet-light (UV)-induced tanning is defective in numerous 'fair-skinned' individuals, many of whom contain functional disruption of the melanocortin 1 receptor (MC1R).
Positive_regulation (disruption) of MC1R associated with melanocortin 1 receptor
7) Confidence 0.50 Published 2006 Journal Nature Section Abstract Doc Link 16988713 Disease Relevance 0 Pain Relevance 0.48
Ultraviolet-light (UV)-induced tanning is defective in numerous 'fair-skinned' individuals, many of whom contain functional disruption of the melanocortin 1 receptor (MC1R).
Positive_regulation (disruption) of melanocortin 1 receptor associated with melanocortin 1 receptor
8) Confidence 0.50 Published 2006 Journal Nature Section Abstract Doc Link 16988713 Disease Relevance 0 Pain Relevance 0.48
For example, whereas Arpc1b is normally induced in the Mc1r+/Mc1r+ basal epidermis, it remained unresponsive in Mc1re/Mc1re animals and is frequently silenced in gastric cancers [53].
Positive_regulation (induced) of Mc1r in epidermis associated with stomach cancer
9) Confidence 0.50 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.54 Pain Relevance 0.13
For example, whereas Arpc1b is normally induced in the Mc1r+/Mc1r+ basal epidermis, it remained unresponsive in Mc1re/Mc1re animals and is frequently silenced in gastric cancers [53].
Positive_regulation (induced) of Mc1r in epidermis associated with stomach cancer
10) Confidence 0.50 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.54 Pain Relevance 0.13
The causative gene Mc1r(taw) of the tawny phenotype is the second recessive allele at the melanocortin 1 receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1r(e)).
Positive_regulation (causative) of Mc1r associated with melanocortin 1 receptor
11) Confidence 0.49 Published 2005 Journal J. Hered. Section Abstract Doc Link 15653560 Disease Relevance 0.24 Pain Relevance 0.10
From a cell-autonomous perspective, phosphorylation of p53 Ser389 is a critical and major step in triggering apoptosis in response to UV-induced DNA damage [66], and it is possible that MC1R activation (either constitutive or in response to UV radiation) plays a permissive role.
Spec (possible) Positive_regulation (activation) of MC1R associated with melanocortin 1 receptor and apoptosis
12) Confidence 0.46 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.61 Pain Relevance 0.58
Thus, mutations that cause either constitutive- or hyper-activation of Mc1r or loss-of-function of Agouti will result in a melanic phenotype.
Positive_regulation (activation) of Mc1r associated with melanocortin 1 receptor
13) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.18 Pain Relevance 0.73
This expression pattern suggested a crucial role of MC-1R signaling in the regulation of MHC class I-restricted immunity.
Positive_regulation (role) of MC-1R
14) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0 Pain Relevance 0
Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.
Positive_regulation (Redundancy) of melanocortin 1 receptor associated with inflammation, melanocortin 1 receptor and cytokine
15) Confidence 0.44 Published 2003 Journal J. Immunol. Section Title Doc Link 12626592 Disease Relevance 0.27 Pain Relevance 0.52
E(+)/E(+) melanocytes express the wild-type melanocortin 1 receptor, e/e melanocytes express a loss-of-function mutation in the melanocortin 1 receptor that results in a yellow coat color, and E(so)/E(so) is a mutation that causes constitutive activation of the melanocortin 1 receptor and renders melanocytes unresponsive to (alpha)-melanocyte stimulating hormone.
Positive_regulation (activation) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
16) Confidence 0.43 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.58
Attractin is required for ASIP effects in the mouse, and was suggested to function to enhance ASIP–MC1R binding (Barsh, 2006).
Positive_regulation (required) of MC1R associated with melanocortin 1 receptor
17) Confidence 0.41 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.19
Modest, if any, expression of MC1R and MC3R mRNA could be detected in the mesenteric tissue of sham-operated mice by quantitative PCR (Fig. 1B), with cycle numbers ranging from 30 to 35; the I/R protocol mildly changed the profile of expression in WT mice, whereas a significant increase of MC1R mRNA in MC3R-null mice was evident (Fig. 1B).
Positive_regulation (increase) of MC1R mRNA
18) Confidence 0.40 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.32 Pain Relevance 0.09
More recent studies (42) performed with a chronic model of inflammation (7-day colitis) demonstrated a proinflammatory phenotype in the recessive yellow e/e mouse, indicating that at least in these experimental conditions activation of MC1R would elicit anti-inflammatory signals with a major outcome on the inflammatory phenotypes of the mouse.
Positive_regulation (activation) of MC1R associated with colitis and inflammation
19) Confidence 0.40 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.88 Pain Relevance 0.41
Hence, our results are in accordance with the earlier findings by Neumann-Andersen et al. showing the expression of MC-1R on natural killer cells and cytotoxic CD8+ T cells whereas only 1% of CD4+ T cells could be stained for MC-1R [57].
Positive_regulation (stained) of MC-1R in T cells
20) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0 Pain Relevance 0

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