INT84769

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 7.56
Pain Relevance 9.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (St8sia1) Golgi apparatus (St8sia1) lipid metabolic process (St8sia1)
Anatomy Link Frequency
spinal 1
spinal cord 1
brains 1
St8sia1 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 48 100.00 Very High Very High Very High
antinociception 27 100.00 Very High Very High Very High
Opioid 26 99.98 Very High Very High Very High
Endocannabinoid 7 99.76 Very High Very High Very High
antagonist 11 99.36 Very High Very High Very High
agonist 3 99.04 Very High Very High Very High
Pain 45 98.68 Very High Very High Very High
narcan 17 98.52 Very High Very High Very High
Spinal cord 8 98.28 Very High Very High Very High
nMDA receptor 3 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 89 100.00 Very High Very High Very High
Pain 24 98.68 Very High Very High Very High
Amyloid Plaque 10 98.20 Very High Very High Very High
Cognitive Disorder 12 97.20 Very High Very High Very High
Neurodegenerative Disease 44 88.96 High High
Hyperalgesia 3 83.20 Quite High
Hypothermia 1 77.08 Quite High
Vascular Disease 2 76.96 Quite High
Alzheimer's Dementia 14 76.52 Quite High
Targeted Disruption 11 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the experiments with selective opioid-receptor antagonists, beta-funaltrexamine (mu) naltrindol (delta), or nor-binaltorphimine (kappa) demonstrated that SIA induced by forced walking stress for 9 successive days may be mediated through opioid delta- and kappa-receptors.
Positive_regulation (induced) of SIA associated with stress, antinociception, antagonist and opioid
1) Confidence 0.41 Published 2000 Journal Pharmacology Section Abstract Doc Link 10940783 Disease Relevance 0.57 Pain Relevance 1.17
Naloxone (10 mg/kg), an opioid-receptor antagonist, was effective in reducing the SIA induced by forced walking stress for 6 days and/or 9 days, but not for 0 days.
Positive_regulation (induced) of SIA associated with stress, antinociception, antagonist, narcan and opioid
2) Confidence 0.41 Published 2000 Journal Pharmacology Section Abstract Doc Link 10940783 Disease Relevance 0.58 Pain Relevance 1.14
Finally, although SIA seemed to be a unitary phenomenon, the present results strengthened the idea that SIA is induced by exposure to forced walking stress with characteristics dependent on the duration of exposure.
Positive_regulation (induced) of SIA associated with stress and antinociception
3) Confidence 0.41 Published 2000 Journal Pharmacology Section Abstract Doc Link 10940783 Disease Relevance 0.62 Pain Relevance 1.11
The present data showed that SIA induced by exposure to forced walking stress was dependent on duration of the stress (0.5-4 h).
Positive_regulation (dependent) of SIA associated with stress
4) Confidence 0.38 Published 1999 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10544389 Disease Relevance 0.62 Pain Relevance 0.27
Thus, the present results suggest that exposure to forced walking stress could cause SIA which may be involved in the nonopioid system via NMDA receptors.
Positive_regulation (cause) of SIA associated with stress and nmda receptor
5) Confidence 0.38 Published 1999 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10544389 Disease Relevance 0.59 Pain Relevance 0.26
The present data showed that SIA induced by exposure to forced walking stress was dependent on duration of the stress (0.5-4 h).
Positive_regulation (induced) of SIA associated with stress
6) Confidence 0.38 Published 1999 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10544389 Disease Relevance 0.62 Pain Relevance 0.26
Brooksbank and McGovern (1989) and Crino et al. (1989) also reported changes of ganglioside composition in AD brains in which b-series gangliosides, such as GT1b and GD1b, showed a significant decrease, in contrast with a slight increase in GT1a, GD3, GM1 and GM2.
Positive_regulation (increase) of GD3 in brains
7) Confidence 0.18 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0.17 Pain Relevance 0.09
Opioid peptides, as well as endocannabinoids, are known mediators of SIA.
Positive_regulation (mediators) of SIA associated with endocannabinoid, opioid and analgesia
8) Confidence 0.16 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18412633 Disease Relevance 0.17 Pain Relevance 1.18
Targeting GD3-synthase would also have the effect of reducing levels of GQ1b?
Positive_regulation (Targeting) of GD3-synthase
9) Confidence 0.13 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0.59 Pain Relevance 0
We conclude that the between-line difference in swim Vo(2) results from a stronger modulation of thermogenic capacities of HA mice by a swim stress-related mechanism, resulting in SIA.
Positive_regulation (resulting) of SIA associated with stress and analgesia
10) Confidence 0.13 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12433863 Disease Relevance 0.31 Pain Relevance 0.46
To further investigate the site of action of NT in mediating SIA, we microinjected NTS2 agonists in lumbar spinal cord and quantified post-stress sensitivity to pain in rats using the plantar test.
Spec (investigate) Positive_regulation (mediating) of SIA in spinal cord associated with stress, pain, agonist, spinal cord and analgesia
11) Confidence 0.04 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 1.15 Pain Relevance 1.23
This adaptive phenomenon referred as stress-induced analgesia (SIA) is mediated by the activation of endogenous pain inhibitory systems.
Positive_regulation (mediated) of SIA associated with stress, pain and analgesia
12) Confidence 0.03 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 0.53 Pain Relevance 1.11
Since central NT produces naloxone-insensitive analgesic effects by acting on spinal and supraspinal NTS2 receptors, we hypothesized that NT might mediate non-opioid SIA through NTS2 activation.
Spec (might) Positive_regulation (activation) of SIA in spinal associated with analgesic, narcan, opioid and analgesia
13) Confidence 0.03 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 1.05 Pain Relevance 1.58

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