INT8477

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Context Info
Confidence 0.58
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 31.52
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AFP) extracellular space (AFP) extracellular region (AFP)
cytoplasm (AFP)
Anatomy Link Frequency
liver 4
peritoneal cavity 2
lateral 2
thyroid 1
lymphocyte 1
AFP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 48 99.74 Very High Very High Very High
Pain 10 98.50 Very High Very High Very High
palliative 5 97.96 Very High Very High Very High
abdominal pain 21 95.56 Very High Very High Very High
Inflammation 18 94.44 High High
alcohol 6 91.60 High High
antagonist 1 85.48 High High
headache 1 84.84 Quite High
imagery 13 82.76 Quite High
Somatostatin 5 82.16 Quite High
Disease Link Frequency Relevance Heat
Paralysis 52 100.00 Very High Very High Very High
Cyst 6 100.00 Very High Very High Very High
Necrosis 10 99.92 Very High Very High Very High
Cancer 182 99.80 Very High Very High Very High
Liposarcoma 15 99.72 Very High Very High Very High
Pressure And Volume Under Development 14 99.56 Very High Very High Very High
Hepatocellular Cancer 158 99.10 Very High Very High Very High
Metastasis 196 98.96 Very High Very High Very High
Pain 10 98.50 Very High Very High Very High
Liver Cancer 8 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 3 months, the level of AFP had remarkably decreased from 4344.0 ng/ml to 418.9 ng/ml.
Negative_regulation (decreased) of AFP
1) Confidence 0.58 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1939849 Disease Relevance 0.86 Pain Relevance 0
The patient underwent a left lateral segmentectomy, did well, and an initial alpha-fetoprotein (AFP) level of 85995 ng/mL decreased to 9 ng/mL.
Negative_regulation (decreased) of AFP in lateral
2) Confidence 0.58 Published 1999 Journal Liver Transpl Surg Section Abstract Doc Link 9873092 Disease Relevance 1.12 Pain Relevance 0.10
The patient underwent a left lateral segmentectomy, did well, and an initial alpha-fetoprotein (AFP) level of 85995 ng/mL decreased to 9 ng/mL.
Negative_regulation (decreased) of alpha-fetoprotein in lateral
3) Confidence 0.58 Published 1999 Journal Liver Transpl Surg Section Abstract Doc Link 9873092 Disease Relevance 1.13 Pain Relevance 0.10
OK-432, an immunomodulatory agent prepared from an attenuated strain of Streptococcus pyogenes, was injected (10 KE) into the peritoneal cavity four times within 1 week; the massive ascites disappeared, and the serum alpha-fetoprotein (AFP) level decreased to within the normal limits.
Negative_regulation (decreased) of AFP in peritoneal cavity associated with pressure and volume under development, cellulitis and sprains and strains
4) Confidence 0.57 Published 2004 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 15619020 Disease Relevance 1.29 Pain Relevance 0.16
In total, 5 patients (24%) had a decrease in serum-AFP levels by at least 30%.
Negative_regulation (decrease) of AFP
5) Confidence 0.57 Published 2000 Journal Int. J. Oncol. Section Abstract Doc Link 10811995 Disease Relevance 0.56 Pain Relevance 0.18
Five of 24 (21%) patients had a median reduction in alpha-fetoprotein levels of 59 ng/mL.
Negative_regulation (reduction) of alpha-fetoprotein
6) Confidence 0.57 Published 1997 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 9195366 Disease Relevance 1.15 Pain Relevance 0
In 10 patients with infiltrating hepatocellular carcinoma, about 70-90% necrosis was achieved; in six of these patients, the alpha-fetoprotein level, which had been more than 200 ng/ml, decreased during treatment.
Negative_regulation (decreased) of alpha-fetoprotein
7) Confidence 0.57 Published 1993 Journal AJR Am J Roentgenol Section Body Doc Link 8273612 Disease Relevance 0.07 Pain Relevance 0
The total injected ethanol volume required ranged from 4 to 15 ml and in most cases both tumor size and alpha-fetoprotein (AFP) levels decreased after LEIT.
Negative_regulation (decreased) of alpha-fetoprotein associated with cancer
8) Confidence 0.57 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 11788887 Disease Relevance 0.67 Pain Relevance 0.10
Secondly, pronounced accumulation of smancs in tumor tissue was observed, which established highly effective chemotherapy of unresectable hepatoma of 22 cases and 12 other cases based on (a) decrease in alpha-fetoprotein (86%), (b) tumor size (95%) and histology.
Negative_regulation (decrease) of alpha-fetoprotein associated with cancer and hepatocellular cancer
9) Confidence 0.57 Published 1982 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 6307179 Disease Relevance 0.67 Pain Relevance 0.06
An initial decline in alpha-fetoprotein levels may represent an early favorable prognostic sign.
Negative_regulation (decline) of alpha-fetoprotein
10) Confidence 0.57 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1373360 Disease Relevance 0.47 Pain Relevance 0.10
Fifty or more % decrease in serum alpha-feto-protein (AFP) levels was observed in 3 of 7 patients (43%) with the initial serum AFP level of more than 200 ng/ml, Fever, abdominal pain, nausea and vomiting were noted in most cases.
Negative_regulation (decrease) of AFP associated with abdominal pain, vomiting and fever
11) Confidence 0.57 Published 1992 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 1381572 Disease Relevance 0.71 Pain Relevance 0.10
OK-432, an immunomodulatory agent prepared from an attenuated strain of Streptococcus pyogenes, was injected (10 KE) into the peritoneal cavity four times within 1 week; the massive ascites disappeared, and the serum alpha-fetoprotein (AFP) level decreased to within the normal limits.
Negative_regulation (decreased) of serum alpha-fetoprotein in peritoneal cavity associated with pressure and volume under development, cellulitis and sprains and strains
12) Confidence 0.51 Published 2004 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 15619020 Disease Relevance 1.30 Pain Relevance 0.16
Initially, the patient's AFP levels dramatically decreased and CT showed regression of metastatic liver tumors; however, multiple new liver metastases appeared and serum AFP levels increased after 5 months.
Negative_regulation (decreased) of AFP in liver associated with liver cancer and metastasis
13) Confidence 0.43 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1939849 Disease Relevance 1.16 Pain Relevance 0
The total injected ethanol volume required ranged from 4 to 15 ml and in most cases both tumor size and alpha-fetoprotein (AFP) levels decreased after LEIT.
Negative_regulation (decreased) of AFP associated with cancer
14) Confidence 0.42 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 11788887 Disease Relevance 0.67 Pain Relevance 0.10
In recent B-ultrasonic examination, the patient's primary focus disappeared, and alpha-fetoprotein test turned to be negative.
Negative_regulation (negative) of alpha-fetoprotein
15) Confidence 0.42 Published 1990 Journal Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 2292117 Disease Relevance 0.31 Pain Relevance 0.08
Partial response (alpha-fetoprotein decrease by greater than or equal to 50% of the initial value) was observed in 10 patients and complete response in 1 patient, always within the fourth dose, with a 10% response rate.
Negative_regulation (decrease) of alpha-fetoprotein
16) Confidence 0.42 Published 1985 Journal Cancer Section Abstract Doc Link 2413981 Disease Relevance 0.51 Pain Relevance 0.12
Serum alpha-fetoprotein (AFP) levels decreased by more than 75 per cent in 10 of 18 patients in whom the previous AFP level was more than 200 ng/ml.
Negative_regulation (decreased) of AFP
17) Confidence 0.42 Published 1988 Journal Acta Radiol Section Abstract Doc Link 2833919 Disease Relevance 0.75 Pain Relevance 0.08
AFP decreased to 33.7 ng/ml and CEA was 8.2 ng/ml.
Negative_regulation (decreased) of AFP
18) Confidence 0.42 Published 1983 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 6191683 Disease Relevance 0.72 Pain Relevance 0.06
Immunohistochemical staining revealed AFP, alpha-1-anti-trypsin (AAT), and carcinoembryonic antigen within the glandular epithelium; AFP and AAT were also present in areas showing the other patterns.
Negative_regulation (revealed) of AFP in epithelium
19) Confidence 0.41 Published 1987 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 3661822 Disease Relevance 0.92 Pain Relevance 0.07
In 40% of tamoxifen-treated patients, the levels of alpha-fetoprotein declined.
Negative_regulation (declined) of alpha-fetoprotein
20) Confidence 0.41 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1373360 Disease Relevance 0.50 Pain Relevance 0.09

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