INT84798

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2006
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.28
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vhl) mitochondrion (Vhl) nucleus (Vhl)
extracellular matrix organization (Vhl) cytoplasm (Vhl)
Anatomy Link Frequency
visceral 1
Vhl (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 3 82.12 Quite High
Dysuria 1 66.12 Quite High
Pain 1 63.64 Quite High
Central nervous system 4 60.48 Quite High
palliative 1 51.84 Quite High
cytokine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 34 100.00 Very High Very High Very High
Hypoxia 3 99.56 Very High Very High Very High
Hemangioblastoma 6 96.24 Very High Very High Very High
Angiomatosis 1 90.56 High High
Hyperplasia 2 82.32 Quite High
Congenital Anomalies 1 80.68 Quite High
Renal Cell Carcinoma 50 77.04 Quite High
Von Hippel-lindau Syndrome 1 70.80 Quite High
Cancer 29 66.40 Quite High
Pain 1 63.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Family history and screening for visceral manifestations of vHL disease were negative.
Neg (negative) Gene_expression (negative) of vHL in visceral associated with disease
1) Confidence 0.48 Published 1999 Journal Neurosurg Rev Section Abstract Doc Link 10547014 Disease Relevance 0.95 Pain Relevance 0.24
In hypoxic conditions or in the absence of VHL, HIF-1a accumulates, stimulating the production of growth factors such as vascular endothelial growth factor (VEGF), transforming growth factor a (TGF?)
Neg (absence) Gene_expression (absence) of VHL associated with hypoxia
2) Confidence 0.32 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 1.33 Pain Relevance 0.11

General Comments

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