INT84809

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 36.42
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
tear 8
epithelial cells 6
pancreas 2
fibroblast 2
bile 2
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 99.98 Very High Very High Very High
endometriosis 6 99.16 Very High Very High Very High
gABA 59 98.92 Very High Very High Very High
Inflammatory mediators 13 98.44 Very High Very High Very High
Chronic pancreatitis 124 98.16 Very High Very High Very High
GABAergic 46 97.86 Very High Very High Very High
cytokine 45 96.80 Very High Very High Very High
Bile 15 96.16 Very High Very High Very High
cINOD 10 95.24 Very High Very High Very High
Inflammation 104 92.16 High High
Disease Link Frequency Relevance Heat
Breast Cancer 157 100.00 Very High Very High Very High
Endometriosis 7 100.00 Very High Very High Very High
Cancer 680 99.92 Very High Very High Very High
Adenocarcinoma 156 99.86 Very High Very High Very High
Pancreatic Cancer 302 99.76 Very High Very High Very High
Syndrome 547 99.68 Very High Very High Very High
Sjoegrens Syndrome 331 99.68 Very High Very High Very High
Carcinoma 34 99.64 Very High Very High Very High
Infection 80 99.52 Very High Very High Very High
Conjunctiva Disease 15 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the neoplastic cells from adenocarcinomas, high levels of cytoplasmic MUC 1 expression were observed, with some membrane staining.
Positive_regulation (levels) of Gene_expression (expression) of MUC 1 associated with adenocarcinoma
1) Confidence 0.70 Published 1999 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 10549250 Disease Relevance 0.46 Pain Relevance 0.18
In vitro, inflammatory mediators that have been found in the tear film of dry eye patients have been shown to increase MUC1 expression in a human limbal corneal epithelial cell line [23].
Positive_regulation (increase) of Gene_expression (expression) of MUC1 in corneal epithelial cell associated with inflammatory mediators and dry eye
2) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.79 Pain Relevance 0.09
Also, ocular cicatricial pemphigoid (OCP) patients demonstrate increased mucin production [56].
Positive_regulation (increased) of Gene_expression (production) of mucin associated with conjunctiva disease
3) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.83 Pain Relevance 0.09
We propose that the conjunctival epithelium of Sjogren’s subjects reacts to dry eye changes in the tear film that cause increased shedding of MUC1 and increased production of this molecule in an attempt to protect the ocular surface and to maintain a healthy surface phenotype.



Positive_regulation (increased) of Gene_expression (production) of MUC1 in tear associated with dry eye
4) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.07 Pain Relevance 0
MUC1 glycoprotein is present in endometriotic lesions and overexpressed in epithelial ovarian tumors.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MUC1 associated with endometriosis and ovarian cancer
5) Confidence 0.68 Published 2006 Journal Immunol. Res. Section Abstract Doc Link 17337783 Disease Relevance 1.43 Pain Relevance 0.35
Our data showed a conspicuous overexpression of CEACAM6 and MUC1 (CA19-9) in pancreatic cancer and cholangiocarcinoma samples, according to the hypothesis that bile fluid collects cancer-associated protein leaking from the tumor microenvironment.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MUC1 in bile associated with bile, cholangiocarcinoma, cancer and pancreatic cancer
6) Confidence 0.68 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19055478 Disease Relevance 1.85 Pain Relevance 0.43
It appears that there is an active upregulation of mucin production in our SS subjects, as determined by increased mRNA, followed by excess shedding of this mucin into the tear film.
Positive_regulation (upregulation) of Gene_expression (production) of mucin in tear associated with syndrome
7) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.69 Pain Relevance 0
This is in contrast to the invasive DACs, which are characterized by an overexpression of MUC1 and the absence of MUC2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MUC1
8) Confidence 0.59 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.83 Pain Relevance 0
In general, immunochemical data obtained by using antibodies raised against the tandem repeat peptide should be analyzed with caution because the staining intensity may be caused by a changed mucin protein expression or by an altered glycosilation.
Positive_regulation (changed) of Gene_expression (expression) of mucin
9) Confidence 0.59 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.35 Pain Relevance 0
Studies have shown, that DACs and tumor cell lines commonly overexpress MUC1 mucin [7,19,22,27].
Positive_regulation (overexpress) of Gene_expression (overexpress) of MUC1 associated with cancer
10) Confidence 0.59 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.27 Pain Relevance 0.15
Recently, overexpression of MUC1 was observed in all stages of PanINs indicating the early occurrence of MUC1 in the development of DACs.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MUC1
11) Confidence 0.59 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.20 Pain Relevance 0.22
Some Lactobacillus strains may stabilize the mucosal barrier by increasing mucin expression, reducing bacterial overgrowth, stimulating mucosal immunity and synthetizing antioxidant substances; these events are altered in NSAID-associated gastroenteropathy.
Positive_regulation (increasing) of Gene_expression (expression) of mucin associated with gastrointestinal disease, cinod and sprains and strains
12) Confidence 0.57 Published 2001 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 11136273 Disease Relevance 0.29 Pain Relevance 0.28
In a recent study, overexpression of MUC6 and the de novo expression of gastric secretory mucin MUC5AC in all stages of PanINs and in invasive DACs was described on RNA and protein level [22].
Positive_regulation (overexpression) of Gene_expression (expression) of mucin
13) Confidence 0.52 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.87 Pain Relevance 0
We propose that the conjunctival epithelium of Sjogren’s subjects reacts to dry eye changes in the tear film that cause increased shedding of MUC1 and increased production of this molecule in an attempt to protect the ocular surface and to maintain a healthy surface phenotype.



Positive_regulation (increased) of Gene_expression (production) of MUC1 in tear associated with dry eye
14) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.07 Pain Relevance 0
Mechanistically, albeit simplistically, it appears that increased expression of mRNAs coding for MUC1 and MUC16 are followed by excess shedding of these species into the tear film, or vice versa.
Positive_regulation (increased) of Gene_expression (expression) of MUC1 in tear
15) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.61 Pain Relevance 0.03
We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC1 and MUC1 mRNA compared to both KCS and NDE groups.
Positive_regulation (concentrations) of Gene_expression (express) of MUC1 associated with sjoegrens syndrome and dry eye
16) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.27 Pain Relevance 0
Transfection of MUC1 siRNAs into MKN7 epithelial cells reduced cell surface MUC1 expression by 80% with the 1?
Positive_regulation (Transfection) of Gene_expression (Transfection) of MUC1 in epithelial cells
17) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.30 Pain Relevance 0
Increased adherence of H. pylori to gastric epithelial cells lacking MUC1
Positive_regulation (Increased) of Neg (lacking) Gene_expression (lacking) of MUC1 in epithelial cells
18) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.31 Pain Relevance 0
Increased soluble MUC1 expression was also found in KCS subjects compared to controls.
Positive_regulation (Increased) of Gene_expression (expression) of MUC1 associated with sjoegrens syndrome
19) Confidence 0.47 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927371 Disease Relevance 1.50 Pain Relevance 0
In fact, excess mucin production in humans is an ancient defense mechanism [51] and non-ocular mucous membranes demonstrate excess mucus production under adverse conditions in dogs, rats, and humans [52-54].
Positive_regulation (excess) of Gene_expression (production) of mucin
20) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.69 Pain Relevance 0.04

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