INT84820

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.50
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 8
sciatic nerve 3
foot skin 1
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 142 100.00 Very High Very High Very High
Sciatic nerve 2 98.96 Very High Very High Very High
Trk A 2 94.28 High High
Neuropeptide 4 84.72 Quite High
substance P 3 83.60 Quite High
calcitonin gene related peptide 2 82.32 Quite High
tricyclic antidepressant 2 81.36 Quite High
hypoalgesia 2 79.04 Quite High
alcohol 26 74.08 Quite High
Neurobehavioral 38 50.00 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 98.32 Very High Very High Very High
Sleep Disorders 2 90.48 High High
Drug Induced Neurotoxicity 2 86.72 High High
Ganglion Cysts 44 80.64 Quite High
Hypoalagesia 2 79.04 Quite High
Attention Deficit Hyperactivity Disorder 48 77.20 Quite High
Cognitive Disorder 58 76.32 Quite High
Congenital Anomalies 18 66.84 Quite High
Fetal Alcohol Syndrome 8 61.32 Quite High
Cv Unclassified Under Development 8 43.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eight weeks of Neotrofin treatment prevented depletion of NGF protein in plantar foot skin and sciatic nerve of diabetic rats and increased NGF protein in associated skeletal muscles.
Negative_regulation (prevented) of Negative_regulation (depletion) of NGF protein in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
1) Confidence 0.59 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16507305 Disease Relevance 0.42 Pain Relevance 0.45
CONCLUSION/INTERPRETATION: These findings show that in animal models of diabetes it is possible to prevent depletions of nerve growth factor and the products of its neuronal target genes by oral treatment of a highly potent inducer of NGF gene expression.
Spec (possible) Negative_regulation (prevent) of Negative_regulation (depletions) of nerve growth factor in nerve
2) Confidence 0.43 Published 1999 Journal Diabetologia Section Body Doc Link 10550414 Disease Relevance 0 Pain Relevance 0
Depletions of nerve growth factor, substance P and CGRP in sciatic nerves of diabetic rats were prevented by CB1093, which also increased soleus nerve growth factor concentrations to 30 % over those seen in non-diabetic rats and increased its mRNA expression in skin.
Negative_regulation (prevented) of Negative_regulation (Depletions) of nerve growth factor in nerve
3) Confidence 0.42 Published 1999 Journal Diabetologia Section Body Doc Link 10550414 Disease Relevance 0 Pain Relevance 0
AG879 significantly reduced the NGF-induced inhibition of M/KCNQ currents from 34 ± 4% to 17 ± 3% (Fig. 3G, n = 7, P < 0.01), whereas it has no effect on Oxo-M–mediated inhibition of M currents (n = 7).
Negative_regulation (reduced) of Negative_regulation (inhibition) of NGF-induced associated with nerve growth factor
4) Confidence 0.42 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.14 Pain Relevance 0.40
Basal forebrain cholinergic neurons were found to be sensitive to nerve growth factor (NGF) deprivation during the first postnatal week not later (Molnar et al., 1997).
Negative_regulation (sensitive) of Negative_regulation (deprivation) of NGF in nerve associated with nerve growth factor
5) Confidence 0.28 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984125 Disease Relevance 0.76 Pain Relevance 0.25
Basal forebrain cholinergic neurons were found to be sensitive to nerve growth factor (NGF) deprivation during the first postnatal week not later (Molnar et al., 1997).
Negative_regulation (sensitive) of Negative_regulation (deprivation) of nerve growth factor in nerve associated with nerve growth factor
6) Confidence 0.28 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984125 Disease Relevance 0.76 Pain Relevance 0.25
Eight weeks of Neotrofin treatment prevented depletion of NGF protein in plantar foot skin and sciatic nerve of diabetic rats and increased NGF protein in associated skeletal muscles.
Negative_regulation (prevented) of in foot skin Negative_regulation (depletion) of NGF protein in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
7) Confidence 0.20 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16507305 Disease Relevance 0.42 Pain Relevance 0.45

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