INT8483

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 73
Total Number 74
Disease Relevance 60.35
Pain Relevance 22.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 6
monocytes 5
lymphocytes 4
polymorphonuclear neutrophils 4
microglia 3
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1291 100.00 Very High Very High Very High
cytokine 849 100.00 Very High Very High Very High
Inflammatory response 87 100.00 Very High Very High Very High
Inflammatory mediators 69 100.00 Very High Very High Very High
Multiple sclerosis 39 100.00 Very High Very High Very High
antagonist 121 99.96 Very High Very High Very High
Lasting pain 4 99.92 Very High Very High Very High
agonist 47 99.88 Very High Very High Very High
Arthritis 247 99.76 Very High Very High Very High
Etanercept 129 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1474 100.00 Very High Very High Very High
Cancer 478 100.00 Very High Very High Very High
Necrosis 119 100.00 Very High Very High Very High
Demyelinating Disease 44 100.00 Very High Very High Very High
Neurodegenerative Disease 21 100.00 Very High Very High Very High
Parkinson's Disease 15 100.00 Very High Very High Very High
Alzheimer's Dementia 13 100.00 Very High Very High Very High
Obesity 607 99.98 Very High Very High Very High
Infection 547 99.98 Very High Very High Very High
Pain 38 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, pentobarbital (pentobarbitone), a short-acting anaesthetic which must be maintained by i.v infusion, therefore requiring further surgical preparation of the animal, induced increases in GM-CSF and TNF?
Positive_regulation (induced) of Positive_regulation (increases) of TNF
1) Confidence 0.67 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1919375 Disease Relevance 0.36 Pain Relevance 0.18
This phenomenon is found in both adults and children with IBD, although in children the TNF increase is particularly elevated in CrohnÂ’s disease (Murch et al. 1993; Breese et al. 1994).
Positive_regulation (elevated) of Positive_regulation (increase) of TNF associated with inflammatory bowel disease and disease
2) Confidence 0.66 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 1.58 Pain Relevance 0.19
Cyclooxygenase inhibition in human monocytes increases endotoxin-induced TNF alpha without affecting cyclooxygenase-2 expression.
Positive_regulation (increases) of Positive_regulation (endotoxin-induced) of TNF in monocytes associated with cox2
3) Confidence 0.50 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15464057 Disease Relevance 0.18 Pain Relevance 0.24
The reason for discontinuation of the prior TNF antagonist was lack of response for 64 patients with AS and 14 patients with PsA, loss of response for 115 patients with AS and 29 patients with PsA, and intolerance for 56 patients with AS and nine patients with PsA (Tables 1 and 2).


Positive_regulation (reason) of Positive_regulation (prior) of TNF associated with spinal inflammation, antagonist and arthritis
4) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911911 Disease Relevance 1.34 Pain Relevance 1.87
Pathways for enhancing TNF-?
Positive_regulation (Pathways) of Positive_regulation (enhancing) of TNF
5) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1199616 Disease Relevance 0.55 Pain Relevance 0.18
with elevated levels of inflammatory mediators like IL-8, LTB4, and TNF-?
Positive_regulation (elevated) of Positive_regulation (elevated) of TNF associated with inflammatory mediators
6) Confidence 0.49 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.19 Pain Relevance 0.22
Increased induction of IL-12p40 and TNF-?
Positive_regulation (Increased) of Positive_regulation (induction) of TNF
7) Confidence 0.49 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.26 Pain Relevance 0.07
cmaA2 mutant of M. tuberculosis which lacks trans-cyclopropanation of mycolic acids stimulated increased TNF-?
Positive_regulation (stimulated) of Positive_regulation (increased) of TNF associated with mycobacterial infection
8) Confidence 0.49 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.31 Pain Relevance 0
In fact, a trend was observed of increased stimulation of TNF-?
Positive_regulation (increased) of Positive_regulation (stimulation) of TNF
9) Confidence 0.49 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.25 Pain Relevance 0.07
Obesity was found to be significantly associated with increase of WBC count (p<0.01), but the observed increase of TNF-?
Positive_regulation (increase) of Positive_regulation (increase) of TNF associated with obesity
10) Confidence 0.49 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.93 Pain Relevance 0.20
These patients present elevated inflammatory mediators such as TNF-?
Positive_regulation (elevated) of Positive_regulation (mediators) of TNF associated with inflammatory mediators
11) Confidence 0.49 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650593 Disease Relevance 1.52 Pain Relevance 0.25
In vitro HCV infection in primary human macrophages resulted in increased TNF-?
Positive_regulation (resulted) of Positive_regulation (increased) of TNF in macrophages associated with hepatitis c virus infection and infection
12) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.51 Pain Relevance 0.06
Since macrophages were the principal cellular component of the inflammatory and degenerative myocardial lesions observed in animals that received CART, and significantly higher levels of TNF-?
Positive_regulation (received) of Positive_regulation (levels) of TNF in macrophages associated with inflammation
13) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009713 Disease Relevance 0.30 Pain Relevance 0.24
An acute bout of exercise attenuated an endotoxin-induced increase in TNF-?
Positive_regulation (induced) of Positive_regulation (increase) of TNF
14) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3022197 Disease Relevance 0.91 Pain Relevance 0.42
Not only does it play a central role by signaling the presence of hypoxia to the transcriptional systems in the nuclei of all cells but it also activates a number of target genes whose products are involved in inflammatory responses such as IL-6, TNF-?
Positive_regulation (activates) of Positive_regulation (activates) of TNF associated with inflammatory response and hypoxia
15) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.14 Pain Relevance 0.13
This augmentation in TNF mRNA accumulation was blocked by yohimbine.
Positive_regulation (augmentation) of Positive_regulation (accumulation) of TNF
16) Confidence 0.46 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2166759 Disease Relevance 0.15 Pain Relevance 0.30
At the transcriptional level, Northern blot analysis demonstrated that UK increased LPS-induced TNF mRNA accumulation.
Positive_regulation (increased) of Positive_regulation (accumulation) of TNF
17) Confidence 0.46 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2166759 Disease Relevance 0.15 Pain Relevance 0.29
In vivo priming of mice with P. acnes also results in elevated serum levels of TNF-?
Positive_regulation (results) of Positive_regulation (elevated) of TNF
18) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.37 Pain Relevance 0.17
On the other hand, in other animal models, administration of IL-18 enhances antigen-induced increase in serum IgE and Th2 cytokines and airway eosinophilia in part by increasing antigen-induced TNF?
Positive_regulation (increasing) of Positive_regulation (induced) of TNF associated with eosinophilia and cytokine
19) Confidence 0.45 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.85 Pain Relevance 0.19
Samples taken from knee joints in which the perfusion needles had been in place for 7 hours while the animal was anaesthetised with urethane (n = 6) showed increased levels of TNF?
Positive_regulation (levels) of Positive_regulation (increased) of TNF in knee joints
20) Confidence 0.45 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1919375 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox