INT8484

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1992
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.12
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
nucleus 3
small intestine 3
spinal cord dorsal horn 1
dorsal horn 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 59 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
Spinal cord 6 99.00 Very High Very High Very High
fluoxetine 5 98.72 Very High Very High Very High
Dorsal horn 5 98.52 Very High Very High Very High
Desipramine 2 98.20 Very High Very High Very High
antidepressant 44 97.80 Very High Very High Very High
Inflammation 93 97.24 Very High Very High Very High
Dorsal horn neuron 2 97.16 Very High Very High Very High
cytokine 36 92.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 104 97.24 Very High Very High Very High
Nociception 9 97.04 Very High Very High Very High
Necrosis 3 95.52 Very High Very High Very High
Cancer 2 95.16 Very High Very High Very High
Stress 12 92.84 High High
Depression 94 88.56 High High
Adhesions 2 88.16 High High
Congenital Anomalies 2 87.76 High High
Anxiety Disorder 23 87.36 High High
Arthritis 11 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colocalization of Fos- and glucocorticoid receptor-immunoreactivities is present only in a very restricted population of dorsal horn neurons of the rat spinal cord after nociceptive stimulation.
Localization (Colocalization) of glucocorticoid receptor in dorsal horn associated with nociception, pain, dorsal horn neuron and spinal cord
1) Confidence 0.53 Published 1993 Journal Brain Res. Section Title Doc Link 8149241 Disease Relevance 0.18 Pain Relevance 0.46
Immunocytochemical techniques were used to study the colocalization of proto-oncogene c-fos protein (Fos)-like immunoreactivity and of glucocorticoid receptor immunoreactivity in the spinal cord dorsal horn of adult male rats after nociceptive stimulation.
Localization (colocalization) of glucocorticoid receptor in spinal cord dorsal horn associated with nociception, dorsal horn and spinal cord
2) Confidence 0.47 Published 1993 Journal Brain Res. Section Abstract Doc Link 8149241 Disease Relevance 0.17 Pain Relevance 0.25
To further understand the mechanism of glucocorticoid effects on intestinal development, we examined the localization of the glucocorticoid receptor in the small intestine.
Spec (examined) Localization (localization) of glucocorticoid receptor in small intestine
3) Confidence 0.44 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
Further, to investigate the mechanism of action of glucocorticoid on intestinal development, we examined the localization and expression of glucocorticoid receptor in the small intestine of rat pups.


Spec (examined) Localization (localization) of glucocorticoid receptor in small intestine
4) Confidence 0.41 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
During the whole weaning period the localization of glucocorticoid receptor did not change.
Localization (localization) of glucocorticoid receptor
5) Confidence 0.38 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
Furthermore, expression and localization of glucocorticoid receptor in the small intestine were determined.
Localization (localization) of glucocorticoid receptor in small intestine
6) Confidence 0.38 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.08 Pain Relevance 0
Additionally, the components of CRx-102 affect the activity of key transcription factors, but not their nuclear localisation nor does it increase glucocorticoid receptor translocation or transcription from positive glucocorticoid response element promoters relative to low dose prednisolone on its own.22 Dipyridamole may contribute to the action of CRx-102 by increasing cAMP in part though inhibition of phosphodiesterases relevant to inflammation, as well as through modulating adenosine transport resulting in increased extra-cellular endogenous adenosine.34 Adenosine can suppress the release of TNF?
Localization (translocation) of glucocorticoid receptor associated with adenocard and inflammation
7) Confidence 0.12 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 0.58 Pain Relevance 0.35
Colocalization of peptide and glucocorticoid receptor immunoreactivities in rat central amygdaloid nucleus.
Localization (Colocalization) of glucocorticoid receptor in nucleus associated with neuropeptide
8) Confidence 0.10 Published 1992 Journal Neuroendocrinology Section Title Doc Link 1373477 Disease Relevance 0.09 Pain Relevance 0.37
Milnacipran, in common with other antidepressants such as desipramine, clomipramine, fluoxetine and clorgyline, has been shown to induce a rapid and sustained translocation of the glucocorticoid receptor into the nucleus of human lymphocytes in vitro (Okuyama-Tamura et al 2003).


Localization (translocation) of glucocorticoid receptor in nucleus associated with desipramine, antidepressant and fluoxetine
9) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654524 Disease Relevance 0.80 Pain Relevance 0.49
Glucocorticoids act through a cytosolic glucocorticoid receptor that eventually translocates into the nucleus and binds to specific DNA sequences called glucocorticoid response elements to regulate gene transcription (Aranda and Pascual, 2001).
Localization (translocates) of cytosolic glucocorticoid receptor in nucleus
10) Confidence 0.02 Published 2008 Journal Clinical Medicine. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2990232 Disease Relevance 1.21 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox