INT84877

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.41
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIN2D) plasma membrane (GRIN2D)
GRIN2D (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 4 100.00 Very High Very High Very High
Analgesic 3 99.98 Very High Very High Very High
antagonist 4 99.96 Very High Very High Very High
Opioid 1 99.24 Very High Very High Very High
Pain 7 98.00 Very High Very High Very High
Morphine 9 97.28 Very High Very High Very High
ketamine 10 97.04 Very High Very High Very High
Hyperalgesia 5 94.48 High High
cINOD 1 93.44 High High
Pain score 1 90.56 High High
Disease Link Frequency Relevance Heat
Pain 8 98.00 Very High Very High Very High
Convulsion 2 97.60 Very High Very High Very High
Hyperalgesia 6 94.48 High High
Psychosis 1 94.36 High High
Dizziness 1 92.16 High High
INFLAMMATION 1 92.00 High High
Hepatotoxicity 3 86.52 High High
Phototoxic Dermatitis 1 84.80 Quite High
Injury 2 80.44 Quite High
Burns 2 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study provides experimental support for a positive analgesic interaction between an N-methyl-D-aspartate receptor antagonist and an opioid on central summation of pain.
N-methyl-D-aspartate receptor Binding (interaction) of associated with pain, antagonist, nmda receptor, analgesic and opioid
1) Confidence 0.48 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15155308 Disease Relevance 1.36 Pain Relevance 2.76
Fluoroquinolones differ in their pro-convulsive activity, relating to their differing potential as gamma-aminobutyric acid antagonists and binding to the N-methyl-D-aspartate receptor.
N-methyl-D-aspartate receptor Binding (binding) of associated with nmda receptor and antagonist
2) Confidence 0.33 Published 1999 Journal Drug Saf Section Abstract Doc Link 10554054 Disease Relevance 1.05 Pain Relevance 0.23

General Comments

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