INT84881

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.79
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
endothelial cell 4
platelet 4
Pecam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 130 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 27 100.00 Very High Very High Very High
analgesia 112 97.08 Very High Very High Very High
Opioid 254 92.88 High High
Endogenous opioid 74 90.00 High High
abdominal pain 3 84.08 Quite High
antinociception 74 80.28 Quite High
aspirin 7 79.16 Quite High
cva 5 75.64 Quite High
cytokine 27 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 143 100.00 Very High Very High Very High
Adhesions 57 100.00 Very High Very High Very High
Shock 4 99.64 Very High Very High Very High
Cancer 10 99.02 Very High Very High Very High
Diabetes Mellitus 26 96.20 Very High Very High Very High
Stress 36 96.00 Very High Very High Very High
Ulcers 26 93.28 High High
Hemangiosarcoma 3 93.24 High High
Abdominal Pain 3 84.08 Quite High
Weight Loss 1 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prolongation of the healing in diabetic animals was associated with an increase in gastric mucosal expression and release of TNFalpha, interleukin-1 beta (IL-1 beta), suppression of the vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM-1) and the mucosal overexpression of heat shock protein 70 (HSP 70).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PECAM in endothelial cell associated with diabetes mellitus, shock and adhesions
1) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.43 Pain Relevance 0.11
The prolongation of the healing in diabetic animals was associated with an increase in gastric mucosal expression and release of TNFalpha, interleukin-1 beta (IL-1 beta), suppression of the vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM-1) and the mucosal overexpression of heat shock protein 70 (HSP 70).
Positive_regulation (overexpression) of Gene_expression (overexpression) of platelet endothelial cell adhesion molecule-1 in endothelial cell associated with diabetes mellitus, shock and adhesions
2) Confidence 0.40 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.50 Pain Relevance 0.11
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Positive_regulation (increased) of Gene_expression (expression) of PECAM-1 in platelet associated with inflammation and adhesions
3) Confidence 0.24 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.71 Pain Relevance 0.89
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Positive_regulation (increased) of Gene_expression (expression) of platelet-endothelial adhesion molecule-1 in platelet associated with inflammation and adhesions
4) Confidence 0.21 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.72 Pain Relevance 0.94
The tumor was composed of epithelioid cells, which showed positive staining for cytokeratin and expression of the common endothelial markers CD31, CD34, and von Willebrand factor.
Positive_regulation (positive) of Gene_expression (expression) of CD31 associated with cancer
5) Confidence 0.11 Published 1999 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 10555012 Disease Relevance 0.84 Pain Relevance 0.08
Furthermore, we found significantly elevated serum levels for sICAM-1 after PTCA and for sPECAM-1 in the tPA group compared with controls and with both of the other therapy groups.
Positive_regulation (elevated) of Gene_expression (group) of sPECAM-1 associated with percutaneous transluminal coronary angioplasty
6) Confidence 0.09 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.59 Pain Relevance 0.23

General Comments

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