INT84888

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.82
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PPARD) nucleoplasm (PPARD) DNA binding (PPARD)
lipid metabolic process (PPARD) cell proliferation (PPARD) lipid binding (PPARD)
Anatomy Link Frequency
epithelial cell 1
PPARD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 13 97.28 Very High Very High Very High
agonist 35 94.24 High High
Inflammatory marker 1 91.56 High High
metalloproteinase 15 86.84 High High
antagonist 4 81.52 Quite High
Inflammation 13 67.60 Quite High
Tendonitis 1 66.92 Quite High
Pain 1 65.80 Quite High
rheumatoid arthritis 5 43.16 Quite Low
Osteoarthritis 5 42.88 Quite Low
Disease Link Frequency Relevance Heat
Weight Gain 2 97.08 Very High Very High Very High
Pressure And Volume Under Development 2 96.44 Very High Very High Very High
INFLAMMATION 20 95.48 Very High Very High Very High
Cancer 51 92.52 High High
Metabolic Syndrome 9 90.72 High High
Atherosclerosis 7 89.40 High High
Disease 8 88.12 High High
Obesity 19 86.84 High High
Repression 5 84.80 Quite High
Colon Cancer 10 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, sulindac was able to disrupt the ability of PPARdelta to bind its recognition sequences.
PPARdelta Binding (bind) of
1) Confidence 0.48 Published 1999 Journal Cell Section Abstract Doc Link 10555149 Disease Relevance 0.50 Pain Relevance 0.46
Currently, clinical studies regarding PPAR delta ligands are lacking.
PPAR delta Binding (ligands) of
2) Confidence 0.09 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1236941 Disease Relevance 1.11 Pain Relevance 0.16
is a nuclear hormone receptor (NHR) initially recognized as a regulator of genes active in adipogenesis and insulin sensitivity [10].
nuclear hormone receptor Binding (recognized) of
3) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.62 Pain Relevance 0.27
Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line.
PPARdelta Binding (influence) of in epithelial cell
4) Confidence 0.04 Published 2005 Journal Oncogene Section Title Doc Link 16091736 Disease Relevance 0.19 Pain Relevance 0.49
heterodimer binds to the peroxisome proliferator responsive element (PPRE)
peroxisome proliferator responsive element Binding (binds) of
5) Confidence 0.00 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 0.28 Pain Relevance 0.07

General Comments

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