INT84889

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.94
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PPARD) nucleoplasm (PPARD) DNA binding (PPARD)
lipid metabolic process (PPARD) cell proliferation (PPARD) lipid binding (PPARD)
Anatomy Link Frequency
cleavage 2
PPARD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 16 93.20 High High
aspirin 7 91.92 High High
antagonist 2 89.76 High High
agonist 2 88.68 High High
psoriasis 3 80.88 Quite High
Inflammation 5 61.28 Quite High
Inflammatory response 1 37.60 Quite Low
Disease Link Frequency Relevance Heat
Skin Cancer 6 99.88 Very High Very High Very High
Keratosis 3 99.72 Very High Very High Very High
Colon Cancer 3 99.64 Very High Very High Very High
Apoptosis 11 97.20 Very High Very High Very High
Repression 1 96.08 Very High Very High Very High
Malignant Neoplastic Disease 1 89.04 High High
Psoriasis 4 80.88 Quite High
INFLAMMATION 9 78.88 Quite High
Disease 1 75.00 Quite High
Cancer 3 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells.
Positive_regulation (elevated) of Gene_expression (expression) of PPARdelta associated with colon cancer
1) Confidence 0.70 Published 1999 Journal Cell Section Abstract Doc Link 10555149 Disease Relevance 0.55 Pain Relevance 0.36
Additionally, the microvessel density is significantly higher in AK and SCC that express high levels of PPARdelta.
Positive_regulation (levels) of Gene_expression (express) of PPARdelta associated with skin cancer and keratosis
2) Confidence 0.23 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.81 Pain Relevance 0.16
Because of suppression of ectopic PPARdelta by sulindac, adenoviral PPARdelta transduction failed to restore 14-3-3epsilon or prevent PPAR cleavage.
Positive_regulation (transduction) of Gene_expression (transduction) of PPARdelta in cleavage
3) Confidence 0.19 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.44 Pain Relevance 0.48
In addition, the overexpression of PPARdelta partially rescued these cells from growth inhibition and also dramatically inhibited sulindac sulfide-mediated p21WAF1/CIP1 upregulation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPARdelta
4) Confidence 0.07 Published 2005 Journal Oncogene Section Abstract Doc Link 16091736 Disease Relevance 0.15 Pain Relevance 0.48

General Comments

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