INT84891

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.80
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PPARD) nucleoplasm (PPARD) DNA binding (PPARD)
lipid metabolic process (PPARD) cell proliferation (PPARD) lipid binding (PPARD)
Anatomy Link Frequency
HASM 1
cleavage 1
PNT1A 1
PPARD (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
agonist 20 99.86 Very High Very High Very High
aspirin 15 99.34 Very High Very High Very High
COX-2 inhibitor 5 98.84 Very High Very High Very High
Inflammation 90 98.24 Very High Very High Very High
cINOD 36 93.20 High High
corticosteroid 1 83.48 Quite High
psoriasis 3 80.88 Quite High
dexamethasone 26 78.04 Quite High
vincristine 2 68.48 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 6 99.88 Very High Very High Very High
Keratosis 3 99.72 Very High Very High Very High
Colon Cancer 20 99.64 Very High Very High Very High
Disease 38 99.28 Very High Very High Very High
Apoptosis 66 98.36 Very High Very High Very High
INFLAMMATION 104 98.24 Very High Very High Very High
Hepatocellular Cancer 8 97.12 Very High Very High Very High
Repression 1 95.04 Very High Very High Very High
Diabetes Mellitus 5 91.32 High High
Cancer 181 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells.
Gene_expression (expression) of PPARdelta associated with colon cancer
1) Confidence 0.78 Published 1999 Journal Cell Section Abstract Doc Link 10555149 Disease Relevance 0.55 Pain Relevance 0.36
Patients with hormone-receptor positive or Her2-positive disease certainly should receive appropriate adjuvant endocrine or trastuzumab therapy.
Gene_expression (positive) of hormone-receptor associated with disease
2) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242653 Disease Relevance 0.39 Pain Relevance 0.06
Besides its anti-inflammatory activity, the COX-2 inhibitor also exerts an anti-proliferative via suppression of the PPAR-delta expression [19].
Gene_expression (expression) of PPAR-delta associated with inflammation and cox-2 inhibitor
3) Confidence 0.39 Published 2008 Journal Cancer Microenviron Section Body Doc Link PMC2654356 Disease Relevance 1.29 Pain Relevance 0.46
Additionally, the microvessel density is significantly higher in AK and SCC that express high levels of PPARdelta.
Gene_expression (express) of PPARdelta associated with skin cancer and keratosis
4) Confidence 0.38 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.81 Pain Relevance 0.16
Neither ASA nor NaS at 1 mM interfered with PPARdelta or 14-3-3epsilon expression.
Gene_expression (expression) of PPARdelta associated with aspirin
5) Confidence 0.29 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.67 Pain Relevance 0.69
Because of suppression of ectopic PPARdelta by sulindac, adenoviral PPARdelta transduction failed to restore 14-3-3epsilon or prevent PPAR cleavage.
Gene_expression (transduction) of PPARdelta in cleavage
6) Confidence 0.25 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.44 Pain Relevance 0.48
Since the peroxisome proliferator-activated receptor was expressed at a very low level and was not stimulated by clofibrate in the AH-130 hepatoma cells, its involvement seems unlikely.
Gene_expression (expressed) of proliferator-activated receptor associated with hepatocellular cancer
7) Confidence 0.13 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.19 Pain Relevance 0.04
In addition, the overexpression of PPARdelta partially rescued these cells from growth inhibition and also dramatically inhibited sulindac sulfide-mediated p21WAF1/CIP1 upregulation.
Gene_expression (overexpression) of PPARdelta
8) Confidence 0.08 Published 2005 Journal Oncogene Section Abstract Doc Link 16091736 Disease Relevance 0.15 Pain Relevance 0.48
In this study, we show that sulindac sulfide acts both as a PPARgamma agonist and a PPARdelta antagonist in an immortalized prostatic epithelial cell line (PNT1A).
Gene_expression (antagonist) of PPARdelta in PNT1A associated with antagonist and agonist
9) Confidence 0.07 Published 2005 Journal Oncogene Section Abstract Doc Link 16091736 Disease Relevance 0.17 Pain Relevance 0.51
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma (not PPARbeta) were expressed in HASM cells.
Gene_expression (expressed) of PPARbeta in HASM
10) Confidence 0.05 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.15 Pain Relevance 0.39

General Comments

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