INT84892

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.85
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PPARD) nucleoplasm (PPARD) DNA binding (PPARD)
lipid metabolic process (PPARD) cell proliferation (PPARD) lipid binding (PPARD)
PPARD (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 4 99.22 Very High Very High Very High
Inflammation 78 98.62 Very High Very High Very High
agonist 4 95.64 Very High Very High Very High
corticosteroid 1 84.24 Quite High
cINOD 5 81.04 Quite High
dexamethasone 25 78.80 Quite High
Inflammatory response 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 3 99.64 Very High Very High Very High
INFLAMMATION 83 98.62 Very High Very High Very High
Repression 1 97.84 Very High Very High Very High
Diabetes Mellitus 1 92.08 High High
Wound Healing 11 85.04 High High
Cancer 140 82.32 Quite High
Thrombophilia 1 58.32 Quite High
Disease 20 55.00 Quite High
Immunotherapy Of Cancer 1 37.08 Quite Low
Injury 1 28.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells.
Negative_regulation (repressed) of Gene_expression (expression) of PPARdelta associated with colon cancer
1) Confidence 0.43 Published 1999 Journal Cell Section Abstract Doc Link 10555149 Disease Relevance 0.55 Pain Relevance 0.37
Besides its anti-inflammatory activity, the COX-2 inhibitor also exerts an anti-proliferative via suppression of the PPAR-delta expression [19].
Negative_regulation (suppression) of Gene_expression (expression) of PPAR-delta associated with inflammation and cox-2 inhibitor
2) Confidence 0.29 Published 2008 Journal Cancer Microenviron Section Body Doc Link PMC2654356 Disease Relevance 1.30 Pain Relevance 0.46

General Comments

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