INT84894

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Context Info
Confidence 0.73
First Reported 1999
Last Reported 2010
Negated 10
Speculated 0
Reported most in Abstract
Documents 45
Total Number 45
Disease Relevance 24.65
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Calb2) cellular_component (Calb2) biological_process (Calb2)
cytoplasm (Calb2)
Anatomy Link Frequency
neurons 11
sensory nerve 2
lamina 2
uterus 2
spinal trigeminal nucleus 2
Calb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 193 100.00 Very High Very High Very High
substance P 160 100.00 Very High Very High Very High
Glutamate 89 100.00 Very High Very High Very High
Neuropeptide 79 100.00 Very High Very High Very High
Somatostatin 77 100.00 Very High Very High Very High
midbrain 25 99.68 Very High Very High Very High
Dorsal horn 30 99.48 Very High Very High Very High
Pain 26 98.80 Very High Very High Very High
GABAergic 209 98.64 Very High Very High Very High
ischemia 312 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 154 99.90 Very High Very High Very High
Ganglion Cysts 9 99.88 Very High Very High Very High
Carcinoma 57 99.68 Very High Very High Very High
Cough 504 99.62 Very High Very High Very High
Apoptosis 52 99.60 Very High Very High Very High
Hyperplasia 7 99.02 Very High Very High Very High
Endometrial Stromal Tumors 3 98.86 Very High Very High Very High
Generalized Anxiety Disorder 56 98.80 Very High Very High Very High
Pain 26 98.80 Very High Very High Very High
Desmoplastic Small Round Cell Tumor 4 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calbindin-D28k (CB), calretinin (CR) and parvalbumin (PV) are the most commonly expressed calcium-binding proteins and are located abundantly in the medullary dorsal horn (also called the caudal subnucleus of the spinal trigeminal nucleus).
Gene_expression (expressed) of CR in spinal trigeminal nucleus associated with dorsal horn
1) Confidence 0.73 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077482 Disease Relevance 0.10 Pain Relevance 0.39
Calbindin-D28k (CB), calretinin (CR) and parvalbumin (PV) are the most commonly expressed calcium-binding proteins and are located abundantly in the medullary dorsal horn (also called the caudal subnucleus of the spinal trigeminal nucleus).
Gene_expression (expressed) of calretinin in spinal trigeminal nucleus associated with dorsal horn
2) Confidence 0.73 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077482 Disease Relevance 0.10 Pain Relevance 0.39
This study was undertaken to determine if nerves associated with the uterus contain calretinin and the source(s) of calretinin-synthesizing nerves in the rat (are they sensory, efferent, or both?).
Gene_expression (synthesizing) of calretinin-synthesizing in uterus
3) Confidence 0.67 Published 1999 Journal Cell Tissue Res. Section Abstract Doc Link 10555540 Disease Relevance 0.07 Pain Relevance 0.07
The present results indicate that there are some neurons co-expressing CB/PKCgamma, CR/PKCgamma and PV/PKCgamma in the medullary dorsal horn.
Gene_expression (expressing) of CR in neurons associated with dorsal horn
4) Confidence 0.64 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077482 Disease Relevance 0 Pain Relevance 0.18
Most of these neurons co-expressing CB/PKCgamma, CR/PKCgamma and PV/PKCgamma were small (</=15 microm) and medium-sized (16-35 microm) neurons and had round, triangular or fusiform-shaped cell bodies; large (>/=36 microm) multipolar neurons were infrequently seen.
Gene_expression (expressing) of CR in neurons
5) Confidence 0.64 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077482 Disease Relevance 0 Pain Relevance 0.21
Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor.
Neg (negative) Gene_expression (negative) of calretinin in leydig cell associated with desmoplastic small round cell tumor, sertoli-leydig cell tumor and hyperplasia
6) Confidence 0.61 Published 2009 Journal Int. J. Gynecol. Pathol. Section Title Doc Link 19851210 Disease Relevance 0.93 Pain Relevance 0.08
Calretinin perikarya were present in the lumbosacral dorsal root ganglia, no-dose ganglia, and lumbosacral spinal cord.
Neg (no) Gene_expression (present) of Calretinin in dorsal root ganglia associated with spinal cord
7) Confidence 0.60 Published 1999 Journal Cell Tissue Res. Section Abstract Doc Link 10555540 Disease Relevance 0.10 Pain Relevance 0.16
Calretinin-immunoreactive terminals were apposed to neurons in the paracervical ganglia; in addition, some postganglionic neurons in this ganglion were calretinin positive.
Gene_expression (positive) of calretinin in ganglion associated with ganglion cysts
8) Confidence 0.59 Published 1999 Journal Cell Tissue Res. Section Abstract Doc Link 10555540 Disease Relevance 0.10 Pain Relevance 0.16
This study was undertaken to determine if nerves associated with the uterus contain calretinin and the source(s) of calretinin-synthesizing nerves in the rat (are they sensory, efferent, or both?).
Gene_expression (synthesizing) of calretinin in uterus
9) Confidence 0.59 Published 1999 Journal Cell Tissue Res. Section Abstract Doc Link 10555540 Disease Relevance 0.07 Pain Relevance 0.07
Immunohistochemically, the tumor cells were negative for epithelial markers but were positive for calretinin and inhibin.
Gene_expression (positive) of calretinin associated with cancer
10) Confidence 0.53 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19851210 Disease Relevance 0.90 Pain Relevance 0.08
Neurons co-expressing CB/PKCgamma, CR/PKCgamma and PV/PKCgamma were also mainly found in lamina II, while in lamina I and lamina III, only a few neurons co-expressing CB/PKCgamma, CR/PKCgamma and PV/PKCgamma were encountered.
Gene_expression (expressing) of CR in lamina
11) Confidence 0.50 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077482 Disease Relevance 0.08 Pain Relevance 0.36
Neurons co-expressing CB/PKCgamma, CR/PKCgamma and PV/PKCgamma were also mainly found in lamina II, while in lamina I and lamina III, only a few neurons co-expressing CB/PKCgamma, CR/PKCgamma and PV/PKCgamma were encountered.
Gene_expression (expressing) of CR in lamina
12) Confidence 0.50 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077482 Disease Relevance 0.07 Pain Relevance 0.34
GABA neurons can be divided into different subgroup based on their expression of calcium-binding proteins: calretinin (CR), calbindin (CB), and parvalbumin (PV) [30].
Gene_expression (expression) of calretinin in neurons associated with gaba
13) Confidence 0.45 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.74 Pain Relevance 0.39
GABA neurons can be divided into different subgroup based on their expression of calcium-binding proteins: calretinin (CR), calbindin (CB), and parvalbumin (PV) [30].
Gene_expression (expression) of CR in neurons associated with gaba
14) Confidence 0.45 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.74 Pain Relevance 0.39
In our study, calretinin-like immunoreactivity was detected in the midbrain at all time points after ischemia.
Gene_expression (detected) of calretinin in midbrain associated with ischemia and midbrain
15) Confidence 0.44 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.24 Pain Relevance 0.43
We counted the total number of neurons (normal, apoptotic, NeuN positive, or CR positive, as defined below for each study) in each brain region on each hemisphere of a single 10?
Gene_expression (positive) of CR in brain associated with apoptosis
16) Confidence 0.44 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.36 Pain Relevance 0.11
Nitric oxide synthase-, calretinin-, choline acetyltransferase-, substance P- and neurokinin receptor-1-immunoreactive neurons were detected in the lateral nuclei.
Gene_expression (detected) of calretinin in neurons associated with substance p
17) Confidence 0.44 Published 2008 Journal Brain Res. Section Abstract Doc Link 18405885 Disease Relevance 0.06 Pain Relevance 0.20
Endometrial stromal tumors with sex cord-like elements, on the other hand, usually express only 1 sex cord marker, mostly calretinin.
Gene_expression (express) of calretinin associated with endometrial stromal tumors
18) Confidence 0.35 Published 2008 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 18317219 Disease Relevance 1.05 Pain Relevance 0
The tumor was negative for mucin, carcinoembryonic antigen, alpha-fetoprotein, calretinin, CD31, and chromogranin.
Neg (negative) Gene_expression (negative) of calretinin associated with cancer
19) Confidence 0.28 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14736268 Disease Relevance 0.76 Pain Relevance 0.11
Most parvalbumin-, several calretinin-, and several pre-proenkephalin-containing neurons expressed the MOR gene in the hippocampal formation.
Gene_expression (expressed) of calretinin in neurons
20) Confidence 0.21 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689476 Disease Relevance 0.19 Pain Relevance 0.51

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