INT8490

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 87
Total Number 89
Disease Relevance 29.73
Pain Relevance 51.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
nerves 5
muscle 3
spinal cord 3
plasma 2
SK-N-MC 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3217 100.00 Very High Very High Very High
Neuropeptide 421 100.00 Very High Very High Very High
antagonist 286 100.00 Very High Very High Very High
headache 144 100.00 Very High Very High Very High
substance P 134 100.00 Very High Very High Very High
Spinal cord 34 100.00 Very High Very High Very High
calcitonin gene related peptide 17 100.00 Very High Very High Very High
fifth nerve 13 100.00 Very High Very High Very High
Neurotransmitter 8 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 405 100.00 Very High Very High Very High
Hypertension 20 100.00 Very High Very High Very High
Migraine Disorders 27 99.92 Very High Very High Very High
Hypercalcemia 25 99.90 Very High Very High Very High
Cluster Headache 19 99.78 Very High Very High Very High
Hypoalagesia 1 99.68 Very High Very High Very High
Frailty 16 99.58 Very High Very High Very High
Hypersensitivity 42 99.48 Very High Very High Very High
Heat Stress Disorders 33 99.42 Very High Very High Very High
Pain 135 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After capsaicin treatment, the content of CGRP-IR was reduced by 70% in the heart and by 60% in the dorsal part of the spinal cord.
Negative_regulation (reduced) of CGRP-IR in spinal cord associated with qutenza, spinal cord and calcitonin gene-related peptide
1) Confidence 0.59 Published 1987 Journal Peptides Section Abstract Doc Link 2438668 Disease Relevance 0.05 Pain Relevance 1.21
The potentiating effect of CGRP was unaffected by in vitro capsaicin pretreatment (10 microM for 15 min), peptidase inhibitors (captopril, bestatin and thiorphan, 1 microM each), apamin (0.3 microM) plus L-nitroarginine (L-NOARG, 100 microM) and by the CGRP1 receptor antagonist, the C-terminal fragment CGRP(8-37) (1 microM).
Neg (unaffected) Negative_regulation (unaffected) of CGRP associated with qutenza, antagonist and calcitonin gene-related peptide
2) Confidence 0.59 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9226396 Disease Relevance 0 Pain Relevance 0.54
In all patients, decreased CGRP-LI was observed in CSF compared to the controls.
Negative_regulation (decreased) of CGRP in CSF
3) Confidence 0.57 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657534 Disease Relevance 0.97 Pain Relevance 0.81
Replacement of the C-terminal amide in this same peptide with a carboxyl, furthermore, resulted in a greater than 50-fold reduction in hCGRP(1) affinity, thus suggesting a direct role for the amide moiety in receptor binding.
Negative_regulation (reduction) of CGRP
4) Confidence 0.57 Published 2001 Journal Biochemistry Section Abstract Doc Link 11444978 Disease Relevance 0.11 Pain Relevance 0.60
The lowest values were found in the patients with osteoarthritis, while there was less, but still significant, reduction of CGRP-LI in the patients with herniated lumbar disc and those with a hip fracture.
Negative_regulation (reduction) of CGRP in hip associated with frailty and osteoarthritis
5) Confidence 0.57 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657534 Disease Relevance 0.98 Pain Relevance 0.80
Spinal nerve ligation results in dramatic changes in spinal cord primary C-afferent fibers, which include atrophy with an accompanied decrease in calcitonin-gene-related peptide (CGRP).
Negative_regulation (decrease) of CGRP in Spinal nerve associated with spinal nerve ligature, frailty and spinal cord
6) Confidence 0.57 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12541147 Disease Relevance 0.27 Pain Relevance 0.50
We show that administration of trkA-IgG produces a sustained thermal and chemical hypoalgesia and leads to a downregulation of the sensory neuropeptide CGRP (calcitonin gene-related peptide) in treated sensory neurons.
Negative_regulation (downregulation) of CGRP in sensory neurons associated with neuropeptide, hypoalgesia and calcitonin gene-related peptide
7) Confidence 0.57 Published 1995 Journal Nat. Med. Section Abstract Doc Link 7585179 Disease Relevance 0.52 Pain Relevance 0.95
OBJECTIVES: To explore whether the accelerated senescence of endothelial progenitor cells (EPCs) is related to the reduction of calcitonin gene-related peptide (CGRP) in hypertension.
Negative_regulation (reduction) of CGRP associated with aging, hypertension and calcitonin gene-related peptide
8) Confidence 0.55 Published 2010 Journal J. Hypertens. Section Abstract Doc Link 20375903 Disease Relevance 0.35 Pain Relevance 0.09
There was a significant binding affinity loss of CGRP(1–36) or CGRP(1–19) when compared to the endogenous neuropeptide for the wild type CLR.
Negative_regulation (loss) of CGRP associated with neuropeptide and calcitonin gene-related peptide
9) Confidence 0.53 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.64
Systemic capsaicin pretreatment induced a marked loss of the CGRP- and SP-immunoreactive (-IR) nerves in the lower airways.
Negative_regulation (loss) of CGRP in nerves associated with qutenza, substance p and calcitonin gene-related peptide
10) Confidence 0.51 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2452458 Disease Relevance 0 Pain Relevance 0.96
Treatment with both oxygen and subcutaneous sumatriptan reduced the CGRP level to normal, while opiate administration did not alter the peptide levels.
Negative_regulation (reduced) of CGRP associated with sumatriptan, opiate and calcitonin gene-related peptide
11) Confidence 0.51 Published 1994 Journal Brain Section Abstract Doc Link 7518321 Disease Relevance 0.47 Pain Relevance 1.44
CONCLUSION: The results suggest that CGRP may work as an endogenous protective substance to counteract EPCs senescence in hypertension and the accelerated EPCs senescence in hypertension was related to the reduction of CGRP.


Negative_regulation (reduction) of CGRP
12) Confidence 0.48 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.05 Pain Relevance 0
Blocking post-junctional CGRP receptors, mediators of trigeminal-induced vasodilation, has been suggested as a potential antimigraine strategy.
Negative_regulation (Blocking) of CGRP associated with cluster headache, increased venous pressure under development and calcitonin gene-related peptide
13) Confidence 0.48 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11955527 Disease Relevance 0.37 Pain Relevance 0.76
In 23 patients there was a decrease in calcitonin levels by at least 50% which was maintained for 4 weeks or longer.
Negative_regulation (decrease) of calcitonin
14) Confidence 0.46 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 0.61 Pain Relevance 0
Absence of these leucine CLR residues cannot explain the entire binding affinity loss of CGRP(1–36) for the wild type receptor.
Negative_regulation (loss) of CGRP associated with calcitonin gene-related peptide
15) Confidence 0.46 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0.06 Pain Relevance 0.69
There was a significant binding affinity loss of CGRP(1–36) or CGRP(1–19) when compared to the endogenous neuropeptide for the wild type CLR.
Negative_regulation (loss) of CGRP associated with neuropeptide and calcitonin gene-related peptide
16) Confidence 0.46 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.64
Triptans might exert their antimigraine effect by reducing the levels of circulating calcitonin gene-related peptide (CGRP).
Negative_regulation (reducing) of calcitonin gene-related peptide associated with cluster headache, triptan and calcitonin gene-related peptide
17) Confidence 0.43 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19266171 Disease Relevance 0.20 Pain Relevance 0.80
Triptans might exert their antimigraine effect by reducing the levels of circulating calcitonin gene-related peptide (CGRP).
Negative_regulation (reducing) of CGRP associated with cluster headache, triptan and calcitonin gene-related peptide
18) Confidence 0.43 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19266171 Disease Relevance 0.20 Pain Relevance 0.80
We have previously shown the depletion of cutaneous calcitonin gene-related peptide (CGRP)- and substance P-containing nerves in human leprosy.
Negative_regulation (depletion) of CGRP in nerves associated with mycobacterium infection, substance p and calcitonin gene-related peptide
19) Confidence 0.43 Published 1990 Journal J. Pathol. Section Abstract Doc Link 1694240 Disease Relevance 0.49 Pain Relevance 0.42
We have previously shown the depletion of cutaneous calcitonin gene-related peptide (CGRP)- and substance P-containing nerves in human leprosy.
Negative_regulation (depletion) of calcitonin gene-related peptide in nerves associated with mycobacterium infection, substance p and calcitonin gene-related peptide
20) Confidence 0.43 Published 1990 Journal J. Pathol. Section Abstract Doc Link 1694240 Disease Relevance 0.49 Pain Relevance 0.42

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