INT84908

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 1999
Negated 0
Speculated 1
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNB3) plasma membrane (GNB3) GTPase activity (GNB3)
signal transducer activity (GNB3)
GNB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 2 77.24 Quite High
ischemia 2 74.52 Quite High
agonist 4 68.40 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 100.00 Very High Very High Very High
Coronary Artery Disease 2 90.88 High High
Bordatella Infection 2 87.64 High High
Cv General 3 Under Development 2 77.24 Quite High
Cv Unclassified Under Development 2 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ischemic events in response to BHT occurred more frequently in 825T allele carriers than in homozygous 825C allele carriers (P=0.01). alpha(2)-Adrenoceptor coronary vasoconstriction is genetically determined and significantly enhanced in GNB3 825T allele carriers.
Spec (determined) Positive_regulation (enhanced) of GNB3 associated with increased venous pressure under development
1) Confidence 0.49 Published 1999 Journal Circ. Res. Section Abstract Doc Link 10559144 Disease Relevance 0.42 Pain Relevance 0.18
G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation.
Positive_regulation (activation) of beta3 subunit associated with increased venous pressure under development
2) Confidence 0.02 Published 1999 Journal Circ. Res. Section Title Doc Link 10559144 Disease Relevance 0.49 Pain Relevance 0.15

General Comments

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