INT84909

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 22.01
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SUGT1) mitosis (SUGT1)
Anatomy Link Frequency
heart 1
SUGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 246 99.62 Very High Very High Very High
agonist 11 99.24 Very High Very High Very High
Fibrositis 94 94.84 High High
Pain 18 94.72 High High
Dopamine 28 94.32 High High
depression 14 93.68 High High
Inflammation 9 89.04 High High
Nucleus accumbens 9 87.60 High High
Serotonin 11 87.12 High High
Angina 23 86.32 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 219 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 21 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 17 100.00 Very High Very High Very High
Coronary Artery Disease 247 99.96 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 249 99.84 Very High Very High Very High
Headache 208 99.62 Very High Very High Very High
Migraine Without Aura 43 99.32 Very High Very High Very High
Stroke 34 99.28 Very High Very High Very High
Myocardial Infarction 147 98.40 Very High Very High Very High
Diabetic Retinopathy 2 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast powerful D2 agonists like bromocryptine show a heightened activation of the reward circuitry only in DRD2 A1 allele carriers.
Positive_regulation (activation) of allele associated with agonist
1) Confidence 0.08 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.51 Pain Relevance 0.85
However, in the present study the D allele frequency was not increased in CRPS I cases (0.51 for D allele, 0.49 for I allele).
Neg (not) Positive_regulation (increased) of D allele associated with complex regional pain syndromes
2) Confidence 0.07 Published 2004 Journal Eur J Pain Section Abstract Doc Link 15109972 Disease Relevance 0.87 Pain Relevance 0.16
However, in the present study the D allele frequency was not increased in CRPS I cases (0.51 for D allele, 0.49 for I allele).
Neg (not) Positive_regulation (increased) of D allele associated with complex regional pain syndromes
3) Confidence 0.07 Published 2004 Journal Eur J Pain Section Abstract Doc Link 15109972 Disease Relevance 0.87 Pain Relevance 0.16
Adiponectin does not seem to play a role in increasing insulin sensitivity in Ala12 allele carriers.
Positive_regulation (increasing) of allele
4) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.18 Pain Relevance 0.08
These data suggest a protective effect of the Ala12 allele in relation to complications associated with T2D.

6.

Positive_regulation (effect) of allele associated with diabetes mellitus
5) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.98 Pain Relevance 0.04
However, the increase in allele C102 frequency fell short of significance.
Positive_regulation (increase) of allele
6) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779444 Disease Relevance 1.07 Pain Relevance 0.56
A higher frequency of the L allele, responsible for enhancing the efficiency of transcription, was found in CAD patients.
Positive_regulation (frequency) of L allele associated with coronary artery disease
7) Confidence 0.03 Published 2009 Journal Int. J. Mol. Med. Section Abstract Doc Link 19885623 Disease Relevance 1.46 Pain Relevance 0.39
Furthermore, in the presence of the R mutant allele and DM2, the odds ratio increases from 5.44 (in presence of the wild type S allele) to 6.11 (p = < 0.001).
Positive_regulation (increases) of allele associated with diabetes mellitus
8) Confidence 0.02 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.55 Pain Relevance 0
In a comparison between the subgroups, with and without CC, the frequency of the HLA-DRB1*09 allele was increased in the Kawasaki disease patients with CC compared with the Kawasaki disease patients without CC (33.3% vs 9.4%; p < 0.04).
Positive_regulation (increased) of allele associated with mucocutaneous lymph node syndrome
9) Confidence 0.02 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 0.91 Pain Relevance 0
Comparison of the subgroups with and without CC showed that the frequency of the HLA-DRB1*09 allele was increased in Kawasaki disease patients with CC compared with the Kawasaki disease patients who had no CC (33.3% vs 9.4%; p < 0.04), and that there was no significant difference in comparison with the healthy control group.
Positive_regulation (increased) of allele associated with mucocutaneous lymph node syndrome
10) Confidence 0.02 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 1.33 Pain Relevance 0
The frequency of the HLA-DRB1*04 allele was slightly increased in the Kawasaki disease patients without CC compared with the healthy control group (p < 0.05; RR = 1.9) (TableĀ 5).



Positive_regulation (increased) of allele associated with mucocutaneous lymph node syndrome
11) Confidence 0.02 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 0.85 Pain Relevance 0
This is consistent with the significantly increased transmission of allele 5 under additive (Z=2.1) and dominant (Z=2.83) models (Table 3).
Positive_regulation (increased) of allele
12) Confidence 0.02 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.61 Pain Relevance 0
According to the additive model, one allele increase was associated with 43% higher risk of MI (OR = 1.43, 95%CI: 1.07-1.93, p = 0.018) as compared to the baseline category of homozygous GG.


Positive_regulation (increase) of allele associated with myocardial infarction
13) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954842 Disease Relevance 0.64 Pain Relevance 0
Regarding the additive model, one allele increase was associated with 43% higher risk of MI (OR = 1.43, 95%CI: 1.07-1.93, p = 0.018) as compared to the baseline category of homozygous GG.
Positive_regulation (increase) of allele associated with myocardial infarction
14) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2954842 Disease Relevance 1.03 Pain Relevance 0
Although the allele frequency were in overall comparable between populations, the distribution of genotypes and alleles across age groups, was different between Hausa and Massalit, with a trend of increase in allele frequency in Massalit over generations and a decrease in Hausa.
Positive_regulation (increase) of allele
15) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829010 Disease Relevance 0.26 Pain Relevance 0
Trabace et al. 2002 [24] found the frequency of the TNFB*2 allele of the TNF-beta gene was significantly increased in patients with migraine without aura as compared with the control group (78.72% versus 61.4%, Pc =.004) [24].
Positive_regulation (increased) of allele associated with migraine
16) Confidence 0.01 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577928 Disease Relevance 1.66 Pain Relevance 1.45
G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation.
Positive_regulation (activation) of allele associated with increased venous pressure under development
17) Confidence 0.01 Published 1999 Journal Circ. Res. Section Title Doc Link 10559144 Disease Relevance 0.49 Pain Relevance 0.15
However once patients were divided into subgroups, MO patients presented a significant increase of the HLADRB* 16 allele.
Positive_regulation (increase) of allele associated with migraine without aura
18) Confidence 0.01 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 1.30 Pain Relevance 0.57
The frequency of the HLA DRB1*12 allele was found to be decreased in patients with migraine while the DRB1*16 allele, coding for HLA DR2 antigen, was significantly increased in comparison with controls.
Positive_regulation (increased) of allele associated with migraine
19) Confidence 0.01 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 1.33 Pain Relevance 0.59
These results suggest a weak association between the R allele and increased CHD risk.
Positive_regulation (increased) of R allele associated with coronary artery disease
20) Confidence 0.01 Published 2004 Journal BMC Genet Section Body Doc Link PMC449704 Disease Relevance 0.37 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox