INT84910

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.74
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNB3) plasma membrane (GNB3) GTPase activity (GNB3)
signal transducer activity (GNB3)
Anatomy Link Frequency
blood 1
GNB3 (Homo sapiens)
GNB3 - C825T (1)
Pain Link Frequency Relevance Heat
Serotonin 52 98.84 Very High Very High Very High
addiction 4 83.48 Quite High
Nicotine 4 83.04 Quite High
agonist 6 82.16 Quite High
Clonidine 1 63.00 Quite High
ischemia 1 55.28 Quite High
Angina 3 50.40 Quite High
Dopamine 12 5.00 Very Low Very Low Very Low
dopamine receptor 8 5.00 Very Low Very Low Very Low
Triptan 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 4 97.80 Very High Very High Very High
Schizophrenia 144 96.48 Very High Very High Very High
Bordatella Infection 1 94.68 High High
Stress 20 92.80 High High
Stroke 1 92.60 High High
Myocardial Infarction 1 92.16 High High
Increased Venous Pressure Under Development 4 89.00 High High
Cv Unclassified Under Development 2 85.04 High High
Nicotine Addiction 4 83.48 Quite High
Obesity 1 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These responses are more pronounced in GNB3*825T allele carriers.


Gene_expression (pronounced) of GNB3
1) Confidence 0.67 Published 2006 Journal Am. Heart J. Section Body Doc Link 16569552 Disease Relevance 0 Pain Relevance 0
GNB3: G-protein beta-3 subunit gene

Competing interests

Gene_expression (interests) of G-protein beta-3 subunit
2) Confidence 0.66 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.26 Pain Relevance 0.07
GNB3: G-protein beta-3 subunit gene

Competing interests

Gene_expression (interests) of GNB3
3) Confidence 0.66 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.26 Pain Relevance 0.07
GNB3 C825T polymorphism
Gene_expression (polymorphism) of GNB3 (C825T)
4) Confidence 0.66 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.48 Pain Relevance 0.18
However, no association between antipsychotic medication response and the occurrence of T-allele, which has been reported to have a GNB3 expression increasing effect [21] was found in this study.


Gene_expression (expression) of GNB3
5) Confidence 0.59 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.50 Pain Relevance 0.16
[C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk].
Gene_expression (codifying) of GNB3 gene
6) Confidence 0.06 Published 2004 Journal Ann. Ital. Med. Int. Section Title Doc Link 15678704 Disease Relevance 0.79 Pain Relevance 0.06
Thus, the 825T allele of the beta3 subunit of heterotrimeric G proteins, associated with enhanced PTX-sensitive G protein signaling, was expected to determine the alpha(2)-adrenoceptor-, but not the alpha(1)-adrenoceptor-, mediated reduction in coronary blood flow (CBF).
Gene_expression (expected) of beta3 subunit in blood
7) Confidence 0.03 Published 1999 Journal Circ. Res. Section Abstract Doc Link 10559144 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

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