INT84921

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 6.39
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF, NTRK1) cell differentiation (NTRK1) signal transduction (NGF)
extracellular space (NGF) extracellular region (NGF) plasma membrane (NTRK1)
Anatomy Link Frequency
nerve 9
joints 1
NGF (Homo sapiens)
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 51 100.00 Very High Very High Very High
antagonist 14 99.04 Very High Very High Very High
Inflammation 53 98.80 Very High Very High Very High
Hsan 16 98.72 Very High Very High Very High
Facet joint 28 98.32 Very High Very High Very High
Pain 110 97.92 Very High Very High Very High
Action potential 8 96.76 Very High Very High Very High
Lasting pain 29 96.12 Very High Very High Very High
Neuronal excitability 1 96.12 Very High Very High Very High
Hyperalgesia 10 89.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 61 98.80 Very High Very High Very High
Pancreatic Cancer 4 98.76 Very High Very High Very High
Cancer 4 98.76 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 16 98.72 Very High Very High Very High
Cold Sores 4 98.40 Very High Very High Very High
Pain 145 97.92 Very High Very High Very High
Nociception 16 97.36 Very High Very High Very High
Apoptosis 9 96.72 Very High Very High Very High
Hyperalgesia 18 90.92 High High
Headache 1 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Congenital insensitivity to pain with anhidrosis (CIPA) is identified as a genetic disorder of mutations in the human TrkA known as high affinity receptor of nerve growth factor (NGF).
nerve growth factor Binding (receptor) of TrkA in nerve associated with nerve growth factor and hsan
1) Confidence 0.50 Published 2004 Journal J. Clin. Immunol. Section Abstract Doc Link 15114061 Disease Relevance 0.92 Pain Relevance 0.89
Congenital insensitivity to pain with anhidrosis (CIPA) is identified as a genetic disorder of mutations in the human TrkA known as high affinity receptor of nerve growth factor (NGF).
NGF Binding (receptor) of TrkA in nerve associated with nerve growth factor and hsan
2) Confidence 0.50 Published 2004 Journal J. Clin. Immunol. Section Abstract Doc Link 15114061 Disease Relevance 0.92 Pain Relevance 0.89
Nerve growth factor (NGF) and its high-affinity receptor TrkA are involved in stimulating epithelial cancer cell growth and perineural invasion, as well as in pain generation in chronic benign disorders.
Nerve growth factor Binding (affinity) of TrkA in Nerve associated with pain and cancer
3) Confidence 0.36 Published 1999 Journal J. Clin. Oncol. Section Abstract Doc Link 10561305 Disease Relevance 0.54 Pain Relevance 0.36
Nerve growth factor (NGF) and its high-affinity receptor TrkA are involved in stimulating epithelial cancer cell growth and perineural invasion, as well as in pain generation in chronic benign disorders.
NGF Binding (affinity) of TrkA in Nerve associated with pain and cancer
4) Confidence 0.36 Published 1999 Journal J. Clin. Oncol. Section Abstract Doc Link 10561305 Disease Relevance 0.54 Pain Relevance 0.36
Interactions of nerve growth factor (NGF) and its receptor tropomyosin-related kinase (trkA) appear to be critical for maintaining HSV latency.
NGF Binding (Interactions) of trkA in nerve associated with cold sores and nerve growth factor
5) Confidence 0.30 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.40 Pain Relevance 0.23
The purpose of this study was to prove the presence of NGF (nerve growth factor) and its receptor TrkA (tyrosine kinase receptor) with immunofluorescence.
nerve growth factor Binding (presence) of TrkA in nerve associated with nerve growth factor
6) Confidence 0.27 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.09 Pain Relevance 0.18
The analysis of these specimens revealed the presence of the neurotrophin (NGF) and its own receptor (TrkA) in all cases: the immunohistochemical reaction between the specimens and the specific antibodies marked with FITC was seen under fluoromicroscopy, but in none of the control cases treated with FITC only.
NGF Binding (presence) of TrkA
7) Confidence 0.27 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.34 Pain Relevance 0.26
The purpose of this study was to prove the presence of NGF (nerve growth factor) and its receptor TrkA (tyrosine kinase receptor) with immunofluorescence.
nerve growth factor Binding (presence) of TrkA in nerve associated with nerve growth factor
8) Confidence 0.27 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.09 Pain Relevance 0.18
The purpose of this study was to prove the presence of NGF (nerve growth factor) and its receptor TrkA (tyrosine kinase receptor) with immunofluorescence.
NGF Binding (presence) of TrkA in nerve associated with nerve growth factor
9) Confidence 0.27 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.09 Pain Relevance 0.18
This study demonstrated the presence of NGF and TrkA in specimens collected from degenerative facet joints, suggesting that specific molecules could be used in order to modulate chronic pain in patients with degenerative lumbar spine.
NGF Binding (presence) of TrkA in joints associated with facet joint and lasting pain
10) Confidence 0.27 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.67 Pain Relevance 0.52
The purpose of this study was to prove the presence of NGF (nerve growth factor) and its receptor TrkA (tyrosine kinase receptor) with immunofluorescence.
NGF Binding (presence) of TrkA in nerve associated with nerve growth factor
11) Confidence 0.27 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.09 Pain Relevance 0.18
There is considerable evidence showing that the system constituted by the NGF and its high-affinity receptor TrkA plays a fundamental role in the molecular processes underlying the main forms of "persistent" pain.
NGF Binding (affinity) of TrkA associated with pain
12) Confidence 0.27 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.61 Pain Relevance 0.48
Only a few small molecule NGF antagonists are available, but ALE0540, which inhibits the binding of NGF to TrkA and p75, and PD90780, which inhibits NGF binding to p75, have been proposed to have efficacy in chronic pain models [154,155].
NGF Binding (binding) of TrkA associated with nerve growth factor, lasting pain and antagonist
13) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.10 Pain Relevance 1.39

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