INT84923

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
pancreas 1
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 10 100.00 Very High Very High Very High
backache 1 52.48 Quite High
Pain 8 50.00 Quite Low
withdrawal 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 169 100.00 Very High Very High Very High
Pancreatic Cancer 10 98.44 Very High Very High Very High
Disease 81 97.44 Very High Very High Very High
Breast Cancer 1 94.04 High High
Pain 7 83.56 Quite High
Cancer 63 82.16 Quite High
Low Back Pain 1 52.48 Quite High
Aggression 3 25.00 Low Low
Diarrhoea 3 11.92 Low Low
Exanthema 2 11.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the expression of NGF receptors (NGFRs: TrkA and p75NGFR) mRNA in 56 human primary pancreatic cancers, using real-time quantitative reverse transcription-PCR.
Spec (investigated) Transcription (expression) of TrkA associated with nerve growth factor and pancreatic cancer
1) Confidence 0.67 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 0.90 Pain Relevance 0.33
RESULTS: Northern blot analysis indicated that NGF and TrkA mRNA levels were increased 2.7-fold and 5.6-fold, respectively (P <.05 and P <.05), in pancreatic cancer tissues compared with the normal pancreas tissue.
Transcription (levels) of TrkA in pancreas
2) Confidence 0.46 Published 1999 Journal J. Clin. Oncol. Section Body Doc Link 10561305 Disease Relevance 0.16 Pain Relevance 0
Mutations in specific regions of the RET gene have been described in MTC, and these occur in both the sporadic and familial form of the disease [141, 142].
Transcription (described) of MTC associated with thyroid neoplasm and disease
3) Confidence 0.45 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 0.59 Pain Relevance 0

General Comments

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