INT84924

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 33
Disease Relevance 17.91
Pain Relevance 16.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 6
sensory nerve 4
cholinergic neurons 2
bladder 2
articular cartilage 2
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 845 100.00 Very High Very High Very High
substance P 155 100.00 Very High Very High Very High
Neuropeptide 114 100.00 Very High Very High Very High
Pain 366 99.92 Very High Very High Very High
cytokine 248 99.90 Very High Very High Very High
Inflammation 165 99.84 Very High Very High Very High
Central nervous system 61 99.68 Very High Very High Very High
Hippocampus 17 99.36 Very High Very High Very High
dexamethasone 11 99.26 Very High Very High Very High
Osteoarthritis 69 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 374 99.92 Very High Very High Very High
Rheumatoid Arthritis 242 99.84 Very High Very High Very High
INFLAMMATION 179 99.84 Very High Very High Very High
Intervertebral Disk Degeneration 40 99.76 Very High Very High Very High
Death 18 99.76 Very High Very High Very High
Arrhythmia Under Development 30 99.20 Very High Very High Very High
Cold Sores 367 98.80 Very High Very High Very High
Injury 23 98.60 Very High Very High Very High
Hypersensitivity 18 98.60 Very High Very High Very High
Osteoarthritis 35 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Drug treatment strategies to enhance production of NGF in the CNS may be useful in the treatment of AD.
Positive_regulation (enhance) of Gene_expression (production) of NGF in CNS associated with nerve growth factor, central nervous system and disease
1) Confidence 0.68 Published 2001 Journal Biol. Psychiatry Section Abstract Doc Link 11230869 Disease Relevance 0.60 Pain Relevance 0.94
Nicotine is one such agent, which, when administered directly to the hippocampus in rats, produces long-lasting elevation of NGF production.
Positive_regulation (elevation) of Gene_expression (production) of NGF in hippocampus associated with nerve growth factor, nicotine and hippocampus
2) Confidence 0.68 Published 2001 Journal Biol. Psychiatry Section Abstract Doc Link 11230869 Disease Relevance 0.56 Pain Relevance 0.88
Overexpression of these factors, with the exception of NGF/Adts, failed to increase axonal sprouting.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of NGF
3) Confidence 0.67 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10844012 Disease Relevance 0.38 Pain Relevance 0.52
inducing greater NGF gene expression.
Positive_regulation (inducing) of Gene_expression (expression) of NGF associated with nerve growth factor
4) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0 Pain Relevance 0.38
in the modulation of neurotrophin expression in the IVD comes from studies by Abe and colleagues, who demonstrated an increase in NGF gene expression and protein secretion after NP cells (cultured in monolayer) were treated with IL-1?
Positive_regulation (increase) of Gene_expression (expression) of NGF associated with nerve growth factor
5) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.35 Pain Relevance 0.42
were shown to increase NGF synthesis and release [27].
Positive_regulation (increase) of Gene_expression (synthesis) of NGF associated with nerve growth factor
6) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.37 Pain Relevance 0.48
resulted in a significant increase in the relative gene expression of both NGF and BDNF in NP cells, with a greater increase in cells from non-degenerate IVD.
Positive_regulation (increase) of Gene_expression (expression) of NGF associated with nerve growth factor
7) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.26 Pain Relevance 0.37
CONCLUSION: The differential expression of neurotrophic factors and their cognate soluble receptors in human vasculitic neuropathy suggests that NGF, which was effectively transferred to sensory axons with p75, may induce pain.


Positive_regulation (transferred) of Gene_expression (transferred) of NGF
8) Confidence 0.67 Published 2003 Journal Intern. Med. Section Body Doc Link 14686749 Disease Relevance 0 Pain Relevance 0
Increased NGF production, therefore, may contribute to OA pain, both structurally (increased and aberrant innervation at the osteochondral junction), and through peripheral sensitization.
Positive_regulation (Increased) of Gene_expression (production) of NGF associated with pain, nerve growth factor and peripheral sensitization
9) Confidence 0.66 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.72 Pain Relevance 0.67
Osteochondral angiogenesis was also associated with increased NGF expression, and may facilitate the sensitization or growth into articular cartilage of sensory nerves.
Positive_regulation (increased) of Gene_expression (expression) of NGF in articular cartilage associated with nerve growth factor
10) Confidence 0.66 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.51 Pain Relevance 0.15
Furthermore, NGF sensitizes nerves [40], such that increased NGF expression in RA and OA may increase sensory nerve activity in the subchondral bone.
Positive_regulation (increased) of Gene_expression (expression) of NGF in sensory nerve associated with nerve growth factor and rheumatoid arthritis
11) Confidence 0.66 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.82 Pain Relevance 0.63
NGF expression is also increased by inflammation, and this is responsible for the collateral nerve fibre sprouting and hypersensitivity of nociceptor fibres associated with inflammation.
Positive_regulation (increased) of Gene_expression (expression) of NGF in nociceptor associated with inflammation, nerve growth factor, nociceptor and hypersensitivity
12) Confidence 0.62 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.46 Pain Relevance 1.55
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Positive_regulation (represents) of Gene_expression (co-expression) of NGF associated with malignant neoplastic disease, nerve growth factor and prostate cancer
13) Confidence 0.50 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.65 Pain Relevance 0.38
The initial report of enhanced NGF production was provided by Bonini et al, indicating that patients with severe allergic BA display high serum levels of NGF [16].
Positive_regulation (enhanced) of Gene_expression (production) of NGF associated with asthma, nerve growth factor and hypersensitivity
14) Confidence 0.49 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.72 Pain Relevance 0.44
Different roles of dexamethasone on transforming growth factor-beta1-induced fibronectin and nerve growth factor expression in dental pulp cells.
Positive_regulation (induced) of Gene_expression (expression) of nerve growth factor in dental pulp associated with nerve growth factor and dexamethasone
15) Confidence 0.49 Published 2007 Journal J Endod Section Title Doc Link 17931932 Disease Relevance 0.19 Pain Relevance 0.60
They then infused nerve growth factor (NGF) into canine left stellate ganglia [7].
Positive_regulation (infused) of Gene_expression (infused) of nerve growth factor in nerve associated with nerve growth factor
16) Confidence 0.49 Published 2006 Journal Clin Auton Res Section Body Doc Link PMC2782122 Disease Relevance 0.99 Pain Relevance 0.29
They then infused nerve growth factor (NGF) into canine left stellate ganglia [7].
Positive_regulation (infused) of Gene_expression (infused) of NGF in nerve associated with nerve growth factor
17) Confidence 0.49 Published 2006 Journal Clin Auton Res Section Body Doc Link PMC2782122 Disease Relevance 1.00 Pain Relevance 0.29
Based on this knowledge we hypothesised that expression of the neurotrophins NGF and BDNF increases with disc degeneration and that they are regulated by IL-1?
Positive_regulation (increases) of Gene_expression (expression) of NGF associated with intervertebral disk degeneration and nerve growth factor
18) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.23 Pain Relevance 0.38
As well as NGF expression, microarray analysis of human disc cells subjected to hyperosmotic stimuli has identified expression and upregulation of BDNF [20].
Positive_regulation (upregulation) of Gene_expression (expression) of NGF associated with nerve growth factor
19) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.19 Pain Relevance 0.50
Furthermore, NGF sensitizes nerves [40], such that increased NGF expression in RA and OA may increase sensory nerve activity in the subchondral bone.
Positive_regulation (increased) of Gene_expression (expression) of NGF in sensory nerve associated with nerve growth factor and rheumatoid arthritis
20) Confidence 0.48 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.82 Pain Relevance 0.63

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