INT84933

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.62
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
monocytes 4
neutrophil 4
blood 2
T cells 2
Schwann cells 2
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 39 99.04 Very High Very High Very High
Inflammation 139 93.64 High High
ischemia 7 92.28 High High
Angina 5 90.04 High High
Neuritis 1 56.68 Quite High
Arthritis 1 50.00 Quite Low
anesthesia 1 37.60 Quite Low
nerve block 1 32.00 Quite Low
Inflammatory response 27 5.00 Very Low Very Low Very Low
Nicotine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 367 99.84 Very High Very High Very High
Adhesions 250 94.72 High High
INFLAMMATION 180 93.64 High High
Coronary Artery Disease 17 92.28 High High
Cv General 3 Under Development 5 90.04 High High
Diabetes Mellitus 5 88.72 High High
Chronic Obstructive Pulmonary Disease 44 79.24 Quite High
Stress 1 75.00 Quite High
Brain Injury 72 73.88 Quite High
Emphysema 2 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of CD62L by PMNs and monocytes were elevated in the NS group across all sample times relative to control, whereas HSD treatment significantly down-regulated CD62L expression at all time points.
Regulation (regulated) of Gene_expression (expression) of CD62L in monocytes
1) Confidence 0.39 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.21 Pain Relevance 0
No ICAM-1, VCAM-1 and L-selectin expression was found on unstimulated Schwann cells.
Regulation (found) of Gene_expression (expression) of L-selectin in Schwann cells
2) Confidence 0.31 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.65 Pain Relevance 0.36
Frequency of CD62L expression on monocytes did not change after the bead isolation procedure (data not shown).


Neg (not) Regulation (change) of Gene_expression (expression) of CD62L in monocytes
3) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773010 Disease Relevance 0 Pain Relevance 0
Accordingly, there is a small, but significant, increase in circulating neutrophil L-selectin expression in smokers [7].
Regulation (circulating) of Gene_expression (expression) of L-selectin in neutrophil associated with nicotine addiction
4) Confidence 0.29 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.83 Pain Relevance 0.12
Accordingly, there is a small, but significant, increase in circulating neutrophil L-selectin expression in smokers [7].
Regulation (circulating) of Gene_expression (expression) of L-selectin in neutrophil associated with nicotine addiction
5) Confidence 0.29 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.83 Pain Relevance 0.12
Changes in the cell surface expression of CD62L and CD11b (represented by mean fluorescent intensity) were measured at each time interval to assess the effect of surgery on these adhesion molecules.


Regulation (Changes) of Gene_expression (expression) of CD62L associated with adhesions
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.09 Pain Relevance 0
There was no effect of labour on the percentage of T cells expressing CD54 (data not shown) or CD62L (Fig. 6F).
Neg (no) Regulation (effect) of Gene_expression (expressing) of CD62L in T cells
7) Confidence 0.22 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0 Pain Relevance 0
Before each pacing step, at peak pacing and shortly after cessation, plasma concentrations of sL-selectin and generation of ROS using the chemiluminescence method were measured in CS and femoral artery blood.
Regulation (concentrations) of Gene_expression (generation) of sL-selectin in blood
8) Confidence 0.03 Published 2000 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 10750129 Disease Relevance 1.00 Pain Relevance 0.25

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