INT84946

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Context Info
Confidence 0.06
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.31
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT5) plasma membrane (GGT5) transferase activity, transferring acyl groups (GGT5)
cellular amino acid metabolic process (GGT5)
Anatomy Link Frequency
plasma 1
GGT5 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 99.32 Very High Very High Very High
abdominal pain 1 94.36 High High
antidepressant 73 79.92 Quite High
pruritus 1 79.68 Quite High
depression 57 78.76 Quite High
Inflammation 16 50.00 Quite Low
methotrexate 1 26.28 Quite Low
cytokine 20 5.00 Very Low Very Low Very Low
sSRI 9 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 2 99.70 Very High Very High Very High
Favism 1 99.42 Very High Very High Very High
Headache 1 99.32 Very High Very High Very High
Convulsion 1 98.44 Very High Very High Very High
Coma 1 98.12 Very High Very High Very High
Liver Failure 1 96.00 Very High Very High Very High
Abdominal Pain 1 94.36 High High
Vomiting 4 93.20 High High
Anaphylaxis 2 88.12 High High
Urticaria 1 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hepatobiliary involvement was reported 25 times, including increases in alkaline phosphatase, gamma-glutamyltransferase, and alanine and aspartate aminotransferase levels.
Gene_expression (levels) of gamma-glutamyltransferase
1) Confidence 0.06 Published 2006 Journal Drug Saf Section Abstract Doc Link 17061910 Disease Relevance 1.60 Pain Relevance 0.13
Reported adverse effects of bitter melon include hypoglycemic coma and convulsions in children, reduced fertility in mice, a favism-like syndrome, increases in gamma-glutamyltransferase and alkaline phosphatase levels in animals, and headaches.
Gene_expression (levels) of gamma-glutamyltransferase associated with convulsion, syndrome, favism, headache and coma
2) Confidence 0.06 Published 2003 Journal Am J Health Syst Pharm Section Abstract Doc Link 12625217 Disease Relevance 0.57 Pain Relevance 0.10
With this in mind, the following 7 (out of the possible 27) genes in the folate pathway will be investigated in the first instance:

• methylenetetrahydrofolate reductase • thymidylate synthase • dihydrofolate reductase • methionine synthase • methionine synthase reductase • gamma glutamyl hydrolase • reduced folate carrier (SLC19A1).

Gene_expression (reductase) of gamma glutamyl
3) Confidence 0.04 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0.08 Pain Relevance 0.08
Gallic acid treatment significantly attenuated some alterations (i.e. increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5'-nucleotidase, bilirubin, alpha-fetoprotein, carcinoembryonic antigen) and decreased the levels of argyophillic nucleolar organizing regions (AgNORs) and proliferating cell nuclear antigen (PCNA) [90].
Gene_expression (levels) of gamma-glutamyltransferase
4) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.06 Pain Relevance 0
We measured plasma levels of alpha-GST, aspartate aminotransferase aspartate, alanine aminotransferase, alkaline phosphatase, pseudocholinesterase, gamma glutamyltransferase and total bilirubin at baseline and several times during and after surgery.
Gene_expression (levels) of gamma glutamyltransferase in plasma
5) Confidence 0.01 Published 1999 Journal Rev Esp Anestesiol Reanim Section Body Doc Link 10563141 Disease Relevance 0 Pain Relevance 0

General Comments

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