INT84959

Context Info Confidence 0.48 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 1.02

plasma membrane (Tacr1, Tac1) extracellular space (Tac1) signal transduction (Tacr1) extracellular region (Tac1) cytoplasm (Tacr1) signal transducer activity (Tacr1)

Anatomy Link Frequency spinal cord 3 Tacr1 (Mus musculus) Tac1 (Mus musculus)

Pain Link Frequency Relevance Heat substance P 9 100.00 Spinal cord 2 99.48 Inflammation 5 97.84 Neuropeptide 2 97.12 Dynorphin 2 81.76 Hyperalgesia 3 79.68 Neurotransmitter 1 54.28

Disease Link Frequency Relevance Heat INFLAMMATION 5 97.84 Nociception 1 94.52 Hyperalgesia 3 79.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Disruption of the substance P receptor (neurokinin-1) gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation.

Negative_regulation (Disruption) of substance P receptor in spinal cord Negative_regulation (prevent) of Positive_regulation (upregulation) of preprotachykinin-A in spinal cord associated with inflammation, spinal cord and substance p

1) Confidence 0.48 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10564361 Disease Relevance 0.59 Pain Relevance 1.02

General Comments

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