INT84964

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 2.80
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOB) small molecule metabolic process (MAOB) oxidoreductase activity (MAOB)
Anatomy Link Frequency
brain 4
blood vessels 2
nerve 2
sympathetic 1
astrocytes 1
MAOB (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 8 100.00 Very High Very High Very High
Nicotine 343 99.40 Very High Very High Very High
Dopamine 18 95.00 High High
cva 4 91.36 High High
Neuronal nitric oxide synthase 1 86.72 High High
Glutamate 3 78.88 Quite High
Serotonin 6 71.68 Quite High
Catecholamine 1 67.84 Quite High
Analgesic 4 50.00 Quite Low
imagery 11 42.96 Quite Low
Disease Link Frequency Relevance Heat
Injury 17 100.00 Very High Very High Very High
End Stage Liver Disease 4 99.40 Very High Very High Very High
Encephalopathy 2 98.66 Very High Very High Very High
Gliosis 1 95.92 Very High Very High Very High
Ganglion Cysts 63 95.64 Very High Very High Very High
Disease 47 95.28 Very High Very High Very High
Increased Venous Pressure Under Development 7 94.16 High High
Cv General 3 Under Development 3 91.36 High High
Pressure And Volume Under Development 5 89.56 High High
Acute Liver Failure 2 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Older monoamine oxidase inhibitors nonselectively inhibited both types A and B, whereas newer selective drugs specifically target MAO type B.
Gene_expression (target) of MAO type B associated with monoamine
1) Confidence 0.61 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2695242 Disease Relevance 0.40 Pain Relevance 0.35
In portal-systemic encephalopathy resulting from chronic liver failure, astrocytes manifest altered expression of several key proteins and enzymes including monoamine oxidase B, glutamine synthetase, and the so-called peripheral-type benzodiazepine receptors.
Gene_expression (expression) of monoamine oxidase B in astrocytes associated with encephalopathy, end stage liver disease and monoamine
2) Confidence 0.24 Published 1999 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10564534 Disease Relevance 1.31 Pain Relevance 0.26
Lesions of individual patients were transferred manually onto a normal reference brain using the MAP-3 technique (Damasio and Frank, 1992; Damasio, 1995; Frank et al., 1997).
Gene_expression (using) of brain in brain
3) Confidence 0.07 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0.20 Pain Relevance 0
However, having produced evidence for the action of adrenalin as well as of nicotine and curare on “accessory” or “receptive” substances of the cell, Langley dared to generalize.
Gene_expression (produced) of adrenalin associated with nicotine
4) Confidence 0.06 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.06 Pain Relevance 0.14
The second problem was Dixon's finding that apocodeine prevented the vascular constricting action of adrenalin, but not that of barium chloride, which suggested that adrenalin acted on nerve fibres, not on muscle fibres.
Neg (not) Gene_expression (acted) of adrenalin in nerve
5) Confidence 0.06 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.07 Pain Relevance 0.10
Dixon had shown that the contraction of the muscle tissue of blood vessels that was typically produced by adrenalin could be almost completely prevented by previous injection of apocodeine.
Gene_expression (produced) of adrenalin in blood vessels
6) Confidence 0.06 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.16 Pain Relevance 0
They were inquisitive, full of energy and elaborate questions, such as "How do you feel when you treat children with brain wounds?"
Gene_expression (wounds) of brain in brain associated with injury
7) Confidence 0.05 Published 2007 Journal Confl Health Section Body Doc Link PMC1890277 Disease Relevance 0.15 Pain Relevance 0
Against this background of conflicting experimental evidence Elliott suggested that it was neither the nerve endings nor the contractile fibres of the muscle cell that were affected by adrenalin.
Gene_expression (affected) of adrenalin in nerve
8) Confidence 0.05 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.14 Pain Relevance 0
This meant (for Brodie and Dixon) that the muscle tissue as such had not been injured by the apocodeine, and that therefore both apocodeine and adrenalin had acted on the nerve endings terminating in the blood vessels.64
Gene_expression (acted) of adrenalin in blood vessels
9) Confidence 0.05 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.15 Pain Relevance 0
Reporting their own experiments and experimental results obtained by other researchers, Brodie and Dixon argued that adrenalin affected the sympathetic nerve endings, not the peripheral tissues themselves.
Neg (not) Gene_expression (affected) of adrenalin in sympathetic
10) Confidence 0.05 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.07 Pain Relevance 0
In the light of Brodie's and Dixon's criticism, Langley gave details of another experiment of his own on a cat, in which he showed that an extract made from “Burroughs and Wellcome's supra-renal tabloids” produced the typical adrenalin effects on the head (eyes, sub-maxillary gland etc.) fourteen and a half months after the superior cervical ganglion had been excised.
Gene_expression (produced) of adrenalin in superior cervical ganglion associated with ganglion cysts
11) Confidence 0.04 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.10 Pain Relevance 0.04
Prednisolone and adrenalin produce analgesic effects through beta2-adrenergic receptors, suggesting an indirect role for beta2-adrenergic receptors in the analgesic effect mechanism of the nonsteroidal antiinflammatory drugs mentioned.


Gene_expression (produce) of adrenalin
12) Confidence 0.03 Published 2010 Journal Crit. Care Med. Section Body Doc Link 20601862 Disease Relevance 0 Pain Relevance 0
The brain response b(t) cannot be fully recovered because there is always some noise contamination, so the estimated brain response is expressed as (t).
Gene_expression (expressed) of brain response in brain
13) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0
"How can a nonlinear brain response be detected by a purely linear mathematical scheme?"
Gene_expression (detected) of brain response in brain
14) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox