INT84965

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.90
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOA) small molecule metabolic process (MAOA) oxidoreductase activity (MAOA)
Anatomy Link Frequency
brain 3
body 2
neuronal 1
1A2 1
MAOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 72 100.00 Very High Very High Very High
monoamine 55 100.00 Very High Very High Very High
Serotonin 38 99.92 Very High Very High Very High
Neuronal nitric oxide synthase 1 99.80 Very High Very High Very High
Dopamine 117 99.72 Very High Very High Very High
Migraine 10 99.52 Very High Very High Very High
5HT 141 99.50 Very High Very High Very High
Triptan 17 98.20 Very High Very High Very High
Catecholamine 6 97.04 Very High Very High Very High
Nicotine 192 94.72 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 82 100.00 Very High Very High Very High
Nicotine Addiction 37 99.82 Very High Very High Very High
Headache 19 99.52 Very High Very High Very High
Pulmonary Hypertension 85 98.20 Very High Very High Very High
Cluster Headache 10 97.88 Very High Very High Very High
Sleep Disorders 96 97.00 Very High Very High Very High
Anxiety Disorder 102 96.88 Very High Very High Very High
Acute Liver Failure 2 95.76 Very High Very High Very High
Disease 71 94.20 High High
End Stage Liver Disease 4 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, expression of some neuronal proteins such as monoamine oxidase A and neuronal nitric oxide synthase are modified.
Gene_expression (expression) of monoamine oxidase A in neuronal associated with neuronal nitric oxide synthase and monoamine
1) Confidence 0.75 Published 1999 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10564534 Disease Relevance 1.26 Pain Relevance 0.31
The product of the gene, monoamine oxidase A, breaks down a multitude of amines including serotonin.
Gene_expression (product) of monoamine oxidase A associated with serotonin and monoamine
2) Confidence 0.75 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2910031 Disease Relevance 0.27 Pain Relevance 0.21
Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage.
Gene_expression (selection) of MAOA gene
3) Confidence 0.67 Published 2004 Journal Hum. Genet. Section Title Doc Link 15349769 Disease Relevance 0.17 Pain Relevance 0.18
A significant association with CM was found for the long allele of monoamine oxidase A 30 bp VNTR and CYP1A2*1F variant.
Gene_expression (allele) of monoamine oxidase A associated with migraine and monoamine
4) Confidence 0.65 Published 2010 Journal J Headache Pain Section Abstract Doc Link 20213484 Disease Relevance 0.54 Pain Relevance 0.95
These four groups were A: Genes preferentially expressed in adult SNI: SERPINA3N, SERPINB2, IL-6 and MMP3, B: Genes preferentially expressed in young SNI: CASPASE 3, TLR4, CLIC-1 and MMP16, C: Genes equally expressed in both adult and young SNI: CREM, MCP-1, MAOA, IPTKC and CSF1; and D: Genes specific to the young SNI group: P2RY14 and C3.
Gene_expression (expressed) of MAOA associated with nervous system injury
5) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2799401 Disease Relevance 1.00 Pain Relevance 0.03
MAO, another catabolizing enzyme of monoamine neurotransmitters, is present in two isoforms (MAO A and MAO B), which share 70% amino acid sequence identity.
Gene_expression (present) of MAO associated with neurotransmitter and monoamine
6) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1543620 Disease Relevance 0.16 Pain Relevance 0.21
Both MAO isoenzymes are present in tissues of the brain, gastrointestinal tract, and liver; however, MAO-A predominates in the gastrointestinal and hepatic tissues and MAO-B in brain tissue (Saura Marti et al 1990).
Gene_expression (present) of MAO in brain
7) Confidence 0.48 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.12 Pain Relevance 0.45
However, conflicting results have been obtained in mice [22] and the results obtained in rats were obtained with a degree of MAO inhibition that is much higher than that observed in the brains of smokers.
Neg (inhibition) Gene_expression (inhibition) of MAO in brains associated with nicotine addiction
8) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794142 Disease Relevance 0.43 Pain Relevance 0.39
Recent studies have found that one or more components of tobacco smoke reduces levels of monoamine oxidase (MAO) in the brain and throughout the body (Fowler et al., 1996a, 1996b, 2003a, 2003b, 2005; Figure 10).
Gene_expression (levels) of monoamine oxidase in body associated with nicotine addiction and monoamine
9) Confidence 0.36 Published 2007 Journal Sci Pract Perspect Section Body Doc Link PMC2851068 Disease Relevance 0.32 Pain Relevance 1.03
Recent studies have found that one or more components of tobacco smoke reduces levels of monoamine oxidase (MAO) in the brain and throughout the body (Fowler et al., 1996a, 1996b, 2003a, 2003b, 2005; Figure 10).
Gene_expression (levels) of MAO in body associated with nicotine addiction and monoamine
10) Confidence 0.36 Published 2007 Journal Sci Pract Perspect Section Body Doc Link PMC2851068 Disease Relevance 0.32 Pain Relevance 1.04
The outer mitochondrial membrane, on the other hand, produces a sizable amount of hydrogen peroxide from the membrane enzyme monoamine oxidase during the catalysis of oxidative deamination of monoamines (such as the catecholamines).
Gene_expression (produces) of monoamine oxidase associated with catecholamine and monoamine
11) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.15 Pain Relevance 0.23
Monoamine oxidase (MAO) type-A inhibitors
Gene_expression (type) of Monoamine oxidase associated with monoamine
12) Confidence 0.21 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526380 Disease Relevance 1.04 Pain Relevance 0.37
MAOA is located on the X chromosome and its upregulation in IPAH suggests a possible involvement in the development IPAH given the female prederiliction of the disease.
Gene_expression (located) of MAOA associated with pulmonary hypertension and disease
13) Confidence 0.17 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.53 Pain Relevance 0.15
CYP1A2, cytochrome P450 1A2; MAO-A, monoamine oxidase A; ALDH, aldehyde dehydrogenase
Gene_expression (1A2) of MAO in 1A2 associated with monoamine
14) Confidence 0.17 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0.10 Pain Relevance 0.15
Although no change was found in platelet (Flament et al 1987), whole blood (Hanna et al 1991; Delorme et al 2004), 5HT content, or in platelet MAO activity (Flament et al 1987), enhancement of CSF levels of 5-HIAA, possibly reflecting increased brain 5HT turnover, was observed in OCD patients (Insel et al 1985).
Gene_expression (levels) of MAO in brain associated with anxiety disorder and 5ht
15) Confidence 0.16 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.49 Pain Relevance 0.37

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