INT84978

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 21.97
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CHDH)
Anatomy Link Frequency
heart 4
blood 2
coronary artery 1
chest 1
CHDH (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 23 98.70 Very High Very High Very High
Angina 65 98.68 Very High Very High Very High
aspirin 34 98.22 Very High Very High Very High
Inflammation 15 97.50 Very High Very High Very High
imagery 32 97.44 Very High Very High Very High
Sciatica 1 87.12 High High
Bile 48 51.52 Quite High
depression 85 50.00 Quite Low
agonist 12 48.04 Quite Low
cva 33 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 762 100.00 Very High Very High Very High
Cv Unclassified Under Development 425 100.00 Very High Very High Very High
Diabetes Mellitus 118 100.00 Very High Very High Very High
Syndrome 91 100.00 Very High Very High Very High
Nicotine Addiction 84 100.00 Very High Very High Very High
Hypertension 62 100.00 Very High Very High Very High
Coronary Heart Disease 21 100.00 Very High Very High Very High
Death 103 99.96 Very High Very High Very High
Sudden Death 1 99.60 Very High Very High Very High
Disorder Of Lipid Metabolism 534 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study used digital infrared thermographic imaging (DITI) for 50 controls and 115 CDH patients, analyzed the data statistically with t-test, and defined the areas of thermatomal change in CDH C3/4, C4/5, C5/6, C6/7 and C7/T1.
Positive_regulation (change) of CDH associated with imagery
1) Confidence 0.50 Published 1999 Journal Yonsei Med. J. Section Abstract Doc Link 10565248 Disease Relevance 0.09 Pain Relevance 0.14
Subjects with a history of CHD or complaining currently of any chest pain were excluded, as were subjects for whom CHD risk factor data were incomplete or missing.
Positive_regulation (history) of CHD in chest associated with angina and coronary artery disease
2) Confidence 0.42 Published 2004 Journal BMC Med Section Body Doc Link PMC515311 Disease Relevance 1.15 Pain Relevance 0.10
This analysis confirms that conventional risk factors for CHD (hypertension, diabetes, smoking and high cholesterol, as well as increasing age and male sex) are independent predictors of coronary artery calcification.
Positive_regulation (increasing) of CHD in coronary artery associated with calcification, nicotine addiction, coronary artery disease, diabetes mellitus and hypertension
3) Confidence 0.42 Published 2004 Journal BMC Med Section Body Doc Link PMC515311 Disease Relevance 1.05 Pain Relevance 0
The S4 and VA-HIT studies did not show a significant association between reduced TG and CHD.19,28 The Helsinki Heart Study, despite documenting a 43% reduction in TG, concluded that an independent effect of TG was not relevant.35 Secondary analysis of the Multiple Risk Factor Intervention Trial, The Lipid Research Clinics Coronary Primary Prevention Trial, and The Lipid Research Clinics Prevalence and Mortality Follow-Up Study showed that TG levels in men do not predict CHD risk, although the same cannot be said of women.36 However, TG is a significant amplifier of CHD in the presence of high LDL-C and low HDL-C.
Neg (not) Positive_regulation (predict) of CHD in Heart associated with coronary artery disease and disorder of lipid metabolism
4) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.91 Pain Relevance 0.03
We now know that high LDL-C levels are associated with increased risk of CHD, and high HDL-C levels are associated with reduced risk of CHD.
Positive_regulation (increased) of CHD associated with coronary artery disease and disorder of lipid metabolism
5) Confidence 0.26 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.36 Pain Relevance 0
A meta-analysis of 17 prospective studies also supports TG as an independent risk factor for CHD.34 The univariant relative risk for CHD with a 1 mmol/L (89 mg/dL) increase in TG was 1.32 (95% CI 1.26–1.39) for men and 1.76 (95% CI 1.50 to 2.07) for women.34 After adjusting for variables such as HDL-C, cholesterol, and other risk factors, the relative risk was 1.14 (95% CI 1.05 to 1.28) for men and 1.37 (95% CI 1.13 to 1.66) for women.34 However, a reduction in TG of 89 mg/dL seems extreme considering that normal levels of TG should be <150 mg/dL, according to ATP III guidelines.
Positive_regulation (increase) of CHD associated with coronary artery disease and disorder of lipid metabolism
6) Confidence 0.26 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.08 Pain Relevance 0
It has been argued that systemic inflammation (of which CRP is a marker) might cause increases in blood pressure, BMI and changes in lipid profiles that might mediate an increase in CIMT and CHD risk [48].
Positive_regulation (increase) of CHD in blood associated with pressure and volume under development, coronary artery disease and inflammation
7) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.75 Pain Relevance 0.05
Therefore, the reduction of estrogen levels which occur during adjuvant therapy for breast cancer may lead to a more atherogenic lipid profile and increased CHD risk.
Positive_regulation (increased) of CHD associated with breast cancer and coronary heart disease
8) Confidence 0.21 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 1.86 Pain Relevance 0
CHD was defined on the basis of an affirmative response to either of the following questions: "Has a doctor, nurse, or health care professional ever told you that you have had a heart attack, also called myocardial infarction?"
Positive_regulation (defined) of CHD in heart associated with coronary artery disease and myocardial infarction
9) Confidence 0.18 Published 2009 Journal Prev Chronic Dis Section Body Doc Link PMC2644595 Disease Relevance 1.72 Pain Relevance 0.08
Table 4 shows the association between circulating CRP and CHD.
Positive_regulation (circulating) of CHD associated with cv unclassified under development
10) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.95 Pain Relevance 0
Previous studies [13] have shown that the main syndromes of CHD are deficiency accompanying with excess, e.g. deficiency of qi syndrome and blood stasis syndrome, deficiency of qi syndrome and turbid phlegm syndrome, deficiency of yang syndrome and turbid phlegm syndrome, blood stasis syndrome and Qi stagnation syndrome, as the predominant combining forms of their syndromes.
Positive_regulation (syndromes) of CHD in blood associated with coronary artery disease and syndrome
11) Confidence 0.16 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921356 Disease Relevance 1.85 Pain Relevance 0
Associations were of a similar magnitude for prevalent CHD (CRP levels measured at same time as history of CHD ascertained) and incident CHD (CRP levels measured before new cases of CHD) in each cohort, and with a combined outcome of prevalent and incident CHD.
Positive_regulation (incident) of CHD associated with cv unclassified under development
12) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.06 Pain Relevance 0
Associations were of a similar magnitude for prevalent CHD (CRP levels measured at same time as history of CHD ascertained) and incident CHD (CRP levels measured before new cases of CHD) in each cohort, and with a combined outcome of prevalent and incident CHD.
Positive_regulation (prevalent) of CHD associated with cv unclassified under development
13) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.05 Pain Relevance 0
Large-scale epidemiological studies have shown that high serum levels of total cholesterol (TC) and LDL-cholesterol (LDL-C) are important risk factors for the development of cardiovascular diseases (CVD), and that low serum levels of HDL-cholesterol (HDL-C) and hypertriglyceridemia (TG) are associated with increased coronary heart diseases (CHD), morbidity and mortality.
Positive_regulation (increased) of CHD in heart associated with cardiovascular disease, coronary heart disease, hyperlipidemia and disorder of lipid metabolism
14) Confidence 0.14 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 1.95 Pain Relevance 0
Residents of England and Wales with ancestral origins in the Indian subcontinent (South Asians) have increased mortality from coronary heart disease (CHD) compared to most other ethnic minority groups, including people of European ancestry (White) [1,9,10].
Positive_regulation (increased) of CHD in heart associated with coronary artery disease
15) Confidence 0.14 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1965474 Disease Relevance 0.55 Pain Relevance 0
A figure of 3.3 was used for the RR for CHD death or sudden death in those with existing CHD, taken from the Framingham study. [21]
Positive_regulation (used) of CHD associated with coronary artery disease, sudden death and death
16) Confidence 0.13 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 2.03 Pain Relevance 0
The mandatory use of aspirin, statins, beta-blockers, and ACE inhibitors in all patients are necessary to reduce the increasing mortality from chronic CHD in India.



Positive_regulation (increasing) of CHD associated with aspirin, coronary artery disease and beta blocker
17) Confidence 0.13 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788593 Disease Relevance 0.10 Pain Relevance 0.10
Only in PRIME, we observed that men homozygotes for the minor allele of the C-689T, Pro12Ala, and C1431T SNPs had a higher risk of CHD than homozygotes for the frequent allele.
Positive_regulation (risk) of CHD associated with coronary artery disease
18) Confidence 0.12 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.43 Pain Relevance 0
As discussed above, many studies have emphasized the graded increase in CHD risk with increasing calcium scores.
Positive_regulation (increase) of CHD associated with coronary artery disease
19) Confidence 0.11 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.28 Pain Relevance 0
Compared with TT genotype of rs2236659, subjects with C allele had lower risk of CHD after adjustment for the conventional risk factors above (Crude odds ratio (OR)?
Positive_regulation (risk) of CHD associated with coronary artery disease
20) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 1.19 Pain Relevance 0

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