INT85018

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Context Info
Confidence 0.24
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 99.98 Very High Very High Very High
narcan 3 98.80 Very High Very High Very High
Opioid 2 91.76 High High
melanocortin 1 receptor 1 90.40 High High
antagonist 6 87.88 High High
Neuropeptide 35 50.00 Quite Low
adenocard 1 36.00 Quite Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
projection neuron 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 3 61.08 Quite High
Infection 3 53.60 Quite High
Body Weight 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Hyperphagia 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Supernatants of both constructs activated the MC4R, with the polymeric VWF-?
Positive_regulation (Supernatants) of Positive_regulation (activated) of MC4R
1) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0.05 Pain Relevance 0
In attempts to identify putative ligand-receptor interactions that may be participating in the agonist induced stimulation of the MC4R, selected ligands were docked into a homology molecular model of the mMC4R.
Positive_regulation (induced) of Positive_regulation (stimulation) of MC4R associated with agonist
2) Confidence 0.18 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 15615519 Disease Relevance 0.06 Pain Relevance 0.49
From these studies we conclude that the acute increased LSNA and MAP in response to i.c.v. leptin may be mediated by increased POMC and its subsequent production of breakdown product alpha-MSH and/or beta-endorphin and it is the subsequent action of alpha-MSH that increases MAP and LSNA by activation of the MC4 receptor.
Positive_regulation (increases) of Positive_regulation (activation) of MC4
3) Confidence 0.03 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10566984 Disease Relevance 0 Pain Relevance 0.27

General Comments

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