INT85023

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.97
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) plasma membrane (Agtr2) transcription factor binding (Agtr2)
signal transducer activity (Agtr2)
Anatomy Link Frequency
muscle 2
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
Inflammation 126 98.84 Very High Very High Very High
withdrawal 1 98.10 Very High Very High Very High
fibrosis 11 83.40 Quite High
Inflammatory response 26 66.00 Quite High
Bioavailability 2 62.16 Quite High
anesthesia 1 25.00 Low Low
cva 17 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 18 99.20 Very High Very High Very High
INFLAMMATION 150 98.84 Very High Very High Very High
Injury 164 97.24 Very High Very High Very High
Cardiovascular Disorder Under Development 73 90.88 High High
Stress 13 89.16 High High
Fibrosis 13 86.84 High High
Adhesions 7 82.56 Quite High
Cancer 64 80.72 Quite High
Arrhythmia Under Development 8 51.12 Quite High
Wound Healing 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effects of candesartan were selective and were similar in animals pretreated with enalaprilat (1 mg/kg iv) to reduce endogenous angiotensin II production.
Negative_regulation (reduce) of Gene_expression (production) of angiotensin II
1) Confidence 0.57 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10567010 Disease Relevance 0 Pain Relevance 0.07
The spatial expression pattern of Angiotensin II receptor is reminiscent of Osteopontin in the early inflammatory cluster, with the brightest staining in the deep dermal or muscle layer of the wild-type wound and only very faint expression seen at the PU.1 null wound site (Figure 7Bh,i).
Negative_regulation (reminiscent) of Gene_expression (expression) of Angiotensin II receptor in muscle associated with inflammation and injury
2) Confidence 0.23 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.90 Pain Relevance 0.38
If a cardiovascular event occurs during therapy, drug withdrawal, with or without additional therapy directed at the HF, such as angiotensin-converting enzyme inhibitors and/or angiotensin II receptor antagonists and/or ?
Negative_regulation (inhibitors) of Gene_expression (antagonists) of angiotensin II receptor associated with antagonist, withdrawal and myocardial infarction
3) Confidence 0.10 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 0.59 Pain Relevance 0.10
It was recently reported that CRP caused a sustained increase in systolic BP in mice, related to an augmented pressor response to angiotensin II that is associated with a NO-sensitive downregulation of vascular angiotensin type 2 receptor expression (Vongpatanasin et al 2007).
Neg (NO) Negative_regulation (downregulation) of Gene_expression (expression) of angiotensin type 2 receptor
4) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.48 Pain Relevance 0.15

General Comments

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