INT85033

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Context Info
Confidence 0.06
First Reported 1999
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna3) transport (Chrna3) plasma membrane (Chrna3)
Chrna3 (Mus musculus)
Chrna3 - H126R (1)
Pain Link Frequency Relevance Heat
monoamine 2 99.76 Very High Very High Very High
agonist 2 91.12 High High
alcohol 6 86.76 High High
gABA 2 75.00 Quite High
Central nervous system 1 75.00 Quite High
tetrodotoxin 1 72.68 Quite High
Serotonin 1 71.60 Quite High
Dopamine 1 70.96 Quite High
Nicotine 2 67.28 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 86.16 High High
Sleep Disorders 2 75.00 Quite High
Stupor 1 75.00 Quite High
Disease 1 60.52 Quite High
Increased Venous Pressure Under Development 1 53.76 Quite High
Nicotine Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combination of diazepam (2 or 3 mg/kg) and ethanol (3 g/kg) induced loss of righting reflex with a significantly dose-dependent increase of the latency to its full recovery in wild-type, alpha1(H101R), alpha3(H126R) and alpha5(H105R) but not in alpha2(H101R) mice.
Positive_regulation (increase) of alpha3 (H126R)
1) Confidence 0.06 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622161 Disease Relevance 0.21 Pain Relevance 0.29
Considering neurochemical, pharmacological and electrophysiological evidence it seems likely that presynaptic nAChRs on monoaminergic fibers are composed of alpha3 or alpha4 subunits in combination with the beta2 subunit.
Positive_regulation (composed) of alpha3 associated with monoamine
2) Confidence 0.04 Published 1999 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 10567725 Disease Relevance 0.14 Pain Relevance 0.38

General Comments

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