INT85047

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.13
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
nerve 2
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 12 99.96 Very High Very High Very High
Nerve growth factor 8 99.96 Very High Very High Very High
palliative 1 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 88 100.00 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 12 99.96 Very High Very High Very High
Cancer 34 87.84 High High
Hypohidrosis 2 87.20 High High
Neuroblastoma 1 56.76 Quite High
Carcinoid 1 13.56 Low Low
Small Cell Lung Cancer 1 13.08 Low Low
Lung Cancer 1 12.84 Low Low
Apoptosis 2 7.96 Low Low
Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor.
Positive_regulation (causes) of Negative_regulation (inactivation) of NTRK1 in nerve associated with nerve growth factor and hsan
1) Confidence 0.47 Published 2000 Journal J. Cell. Physiol. Section Title Doc Link 10567924 Disease Relevance 0.61 Pain Relevance 0.70
Our results demonstrate clearly that the CIPA mutations cause the inactivation of the NTRK1 receptor, thus exerting a loss of function effect, and provide an experimental approach to distinguish functional mutations from genetic polymorphisms.
Positive_regulation (cause) of Negative_regulation (inactivation) of NTRK1 receptor associated with hsan
2) Confidence 0.47 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.53 Pain Relevance 0.60
More importantly, ectopic raf-1 expression led to significant MTC growth suppression both in vitro and in a mouse xenograft model of MTC [40–43].
Positive_regulation (led) of Negative_regulation (suppression) of MTC associated with thyroid neoplasm
3) Confidence 0.09 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.99 Pain Relevance 0

General Comments

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