INT85048

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 11.61
Pain Relevance 10.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 3
nociceptor 3
CSF 2
hippocampus 2
spinal 1
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 241 100.00 Very High Very High Very High
Pain 344 99.96 Very High Very High Very High
Central nervous system 73 99.64 Very High Very High Very High
Lasting pain 15 99.56 Very High Very High Very High
Hippocampus 7 99.02 Very High Very High Very High
Hsan 7 99.00 Very High Very High Very High
cytokine 69 98.76 Very High Very High Very High
nociceptor 34 98.40 Very High Very High Very High
diabetic neuropathy 12 97.70 Very High Very High Very High
Hyperalgesia 6 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 344 99.96 Very High Very High Very High
Rheumatoid Arthritis 6 99.68 Very High Very High Very High
Prostate Cancer 8 99.20 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 7 99.00 Very High Very High Very High
Hydrocephalus 3 98.96 Very High Very High Very High
Cancer 214 98.64 Very High Very High Very High
Neuropathic Pain 35 98.64 Very High Very High Very High
Nociception 22 98.28 Very High Very High Very High
Diabetic Neuropathy 12 97.70 Very High Very High Very High
Malignant Neoplastic Disease 4 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a dysregulation of NGF signal transduction was found in a number of human tumors.
Regulation (dysregulation) of NGF associated with nerve growth factor and cancer
1) Confidence 0.62 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.72 Pain Relevance 0.38
The menstrual cycle influences on NGF levels are also difficult to determine with the current sample size.
Regulation (influences) of NGF associated with nerve growth factor
2) Confidence 0.55 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 0.42 Pain Relevance 0.62
We hypothesized that CIPA may represent a natural model for impaired NGF effect on insulin secretion in humans.
Regulation (effect) of NGF associated with nerve growth factor
3) Confidence 0.42 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279365 Disease Relevance 0.34 Pain Relevance 0.40
Point mutations affecting the NTRK1/TRKA gene, encoding one of the receptors for the nerve growth factor (NGF), have been detected in congenital insensitivity to pain with anhidrosis (CIPA), a human hereditary sensory neuropathy characterized by absence of reaction to noxious stimuli and anhidrosis.
Regulation (affecting) of NGF in nerve associated with hypohidrosis, nerve growth factor and hsan
4) Confidence 0.41 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.54 Pain Relevance 0.61
The findings reveal a central role of the endothelial cell in initiating NGF-dependent inflammatory hyperalgesia and emphasize the importance of further investigations aimed at examining the feasibility of new therapeutic strategies that target NGF.
Regulation (target) of NGF in endothelial cell associated with hyperalgesia, inflammation and nerve growth factor
5) Confidence 0.27 Published 2003 Journal FASEB J. Section Abstract Doc Link 12958182 Disease Relevance 0.77 Pain Relevance 1.03
RESULTS: The CSF concentrations of CNTF, BDNF, and NGF did not differ between the 3 patient cohorts.
Regulation (concentrations) of NGF in CSF
6) Confidence 0.27 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.26 Pain Relevance 0
METHODS: The concentrations of GDNF, BDNF, CNTF, and NGF were analyzed in the lumbar CSF of 10 patients with chronic neuropathic pain, in 20 patients with lumbar back pain undergoing myelography, and in 10 patients with normal pressure hydrocephalus, by using enzymes-linked immunosorbent assay techniques.
Regulation (concentrations) of NGF in CSF
7) Confidence 0.27 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.29 Pain Relevance 0
DISCUSSION: We did not detect any difference between patients with neuropathic versus nociceptive pain and nonpainful controls for spinal CNTF, BDNF, and NGF levels.
Neg (not) Regulation (controls) of NGF in spinal
8) Confidence 0.27 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.22 Pain Relevance 0
Additional studies investigating innervation in the degenerate IVD have also demonstrated expression of Trk-A, the high-affinity receptor for nerve growth factor (NGF), on ingrowing nerves – indicating that such nerves are NGF sensitive [4].
Regulation (sensitive) of NGF in nerves associated with nerve growth factor
9) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.27 Pain Relevance 0.51
We hypothesized a relationship between clinical breast pain, nerve growth factor (NGF) and its regulated ion channels or receptors expressed by nociceptor fibres.
Regulation (regulated) of nerve growth factor in nociceptor associated with pain, nerve growth factor and nociceptor
10) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.44 Pain Relevance 1.39
We hypothesized a relationship between clinical breast pain, nerve growth factor (NGF) and its regulated ion channels or receptors expressed by nociceptor fibres.
Regulation (regulated) of NGF in nociceptor associated with pain, nerve growth factor and nociceptor
11) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.38 Pain Relevance 1.33
As NGF is a key molecule that determines the sensitivity of nociceptors in humans [13] and animal models [14], sex hormonal influences could be responsible for altered NGF activity during the menstrual cycle, leading to cyclical breast soreness or pain.
Regulation (altered) of NGF in nociceptors associated with pain, nerve growth factor and nociceptor
12) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.43 Pain Relevance 1.50
Results suggesting a protective effect of NGF in patients with diabetic neuropathy were obtained in a phase 2 human trial but the following phase 3 prospective randomized control trial of efficacy NGF was found to be ineffective in preventing the progression of neuropathy [54].
Regulation (ineffective) of NGF associated with nerve growth factor, diabetic neuropathy and neuropathic pain
13) Confidence 0.22 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.82 Pain Relevance 0.54
Exposure to 1 mg/kg also decreased NGF content in hippocampus, septum and neostriatum whereas 50 mg/kg had no effect on NGF content but decreased the number of NGF high affinity binding sites [298].
Neg (no) Regulation (effect) of NGF in hippocampus associated with hippocampus
14) Confidence 0.21 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0 Pain Relevance 0.29
had stimulatory effects on NGF.
Regulation (effects) of NGF associated with nerve growth factor
15) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.49 Pain Relevance 0.64
The role of TRPs in keratinocytes is unknown, but a relationship to changes in NGF levels, which is produced by keratinocytes, deserves investigation.
Regulation (changes) of NGF in keratinocytes associated with nerve growth factor
16) Confidence 0.19 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 0.74 Pain Relevance 0.56
NTs underlie an endogenous mechanism of CNS repair [31], and disregulation of NGF underlies chronic pain (e.g., in cancer) [32].
Regulation (disregulation) of NGF associated with nerve growth factor, cancer, lasting pain and central nervous system
17) Confidence 0.15 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2586362 Disease Relevance 1.12 Pain Relevance 0.31
Whilst developmental studies on naltrexone’s effect on neurochemistry are sparse, daily injections (50 mg/kg) of rat pups had variable effects on NGF, with decreases in cerebellum and increases in the hippocampus [268].
Regulation (effects) of NGF in hippocampus associated with hippocampus
18) Confidence 0.09 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0 Pain Relevance 0.28
Controlled media containing DMEM, B27, N2, BDNF, EGF, nerve growth factor (NGF), RA, dBcAMP, collagen and fibronectin have also showed success.
Regulation (Controlled) of nerve growth factor in nerve associated with nerve growth factor and rheumatoid arthritis
19) Confidence 0.02 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 0.24 Pain Relevance 0.10

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