INT85078

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 17.06
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
epithelial cells 4
HGF 4
TM3 2
hepatocyte 1
pseudotumor 1
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 46 98.50 Very High Very High Very High
gABA 124 98.16 Very High Very High Very High
Inflammation 154 97.68 Very High Very High Very High
antagonist 29 90.44 High High
cINOD 36 87.96 High High
COX-2 inhibitor 59 82.92 Quite High
palliative 5 79.68 Quite High
cytokine 88 79.40 Quite High
GABA receptor 18 78.00 Quite High
metalloproteinase 24 75.00 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 131 99.84 Very High Very High Very High
Metastasis 146 99.82 Very High Very High Very High
Cirrhosis 29 99.64 Very High Very High Very High
Cancer 807 99.58 Very High Very High Very High
Lymphatic System Cancer 60 99.16 Very High Very High Very High
Carcinoma 133 99.04 Very High Very High Very High
Residual Neoplasm 75 98.92 Very High Very High Very High
Disease 222 98.04 Very High Very High Very High
Hepatocellular Cancer 164 97.76 Very High Very High Very High
INFLAMMATION 162 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, there was a positive correlation between the increase in IL-6 and the increase in PCNA co-localization with Pax7 early in the post-intervention time-course.
Positive_regulation (increase) of PCNA
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.09 Pain Relevance 0.03
AEC2 from hyperoxic pups also expressed increased levels of proliferating cell nuclear antigen early in life compared with control neonatal AEC2, suggesting that oxygen-induced proliferation and/or repair were occurring.
Positive_regulation (increased) of proliferating cell nuclear antigen in AEC2
2) Confidence 0.45 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12225951 Disease Relevance 0.09 Pain Relevance 0.12
Neither such elevation of proliferating cell nuclear antigen index nor the suppression of apoptotic index could be found in chronic non-steroidal anti-inflammatory drugs users.
Neg (Neither) Positive_regulation (elevation) of proliferating cell nuclear antigen
3) Confidence 0.45 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.16 Pain Relevance 0
A significant elevation of proliferating cell nuclear antigen index and suppression of apoptotic index was observed in Barrett's epithelium with superficial epithelial cyclo-oxygenase-2 expression.
Positive_regulation (elevation) of proliferating cell nuclear antigen in epithelium
4) Confidence 0.45 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.19 Pain Relevance 0
This gastric adaptation was accompanied by an increase in PCNA positive cells, particularly on days 7 and 14.
Positive_regulation (increase) of PCNA
5) Confidence 0.41 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10571615 Disease Relevance 0 Pain Relevance 0
Many of the "fingerprint genes" identified in these studies were consistent with previous observations reported in the literature (e. g., the well-characterized induction by cisplatin of p53-regulated transcripts such as p21(waf1/cip1) and PCNA [proliferating cell nuclear antigen]).
Positive_regulation (induction) of PCNA
6) Confidence 0.41 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 11099651 Disease Relevance 0.22 Pain Relevance 0.30
Paradoxically, however the appearance of elevated PCNA levels (a second S-phase marker of the cell cycle) are not disease correlated.
Positive_regulation (elevated) of PCNA associated with disease
7) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 1.03 Pain Relevance 0
The increase in Pax7+/IL-6+ cells positively correlated with the increase in Pax7+/PCNA+ cells observed from PRE to T24 (R2?
Positive_regulation (increase) of PCNA in T24
8) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.08 Pain Relevance 0
Stromal staining for bFGF and PCNA was significantly increased in adenomyosis compared with autologous endometrium.
Positive_regulation (increased) of PCNA in endometrium
9) Confidence 0.32 Published 2001 Journal Menopause Section Body Doc Link 11528364 Disease Relevance 0.15 Pain Relevance 0
Significantly improved Child-Pugh scores were seen at 4 and 24 weeks (p < .05). alpha-Fetoprotein and proliferating cell nuclear antigen (PCNA) expression in liver biopsy tissue was significantly elevated after ABMI therapy (p < .05).
Positive_regulation (elevated) of proliferating cell nuclear antigen in liver
10) Confidence 0.21 Published 2006 Journal Stem Cells Section Abstract Doc Link 16778155 Disease Relevance 0.42 Pain Relevance 0.11
Concerning cell cycle, PKB is able to phosphorylate cdk inhibitors, such as p21 and p27, leading to PCNA activation [168, 169].
Positive_regulation (activation) of PCNA
11) Confidence 0.20 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.80 Pain Relevance 0.13
In one study, PCNA activity was markedly increased in the higher grade lymphoma group compared to that in the low grade lymphoma and orbital pseudotumor group.
Positive_regulation (increased) of PCNA in pseudotumor associated with lymphatic system cancer
12) Confidence 0.17 Published 2008 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2848795 Disease Relevance 1.79 Pain Relevance 0.16
We measured the cell proliferation marker PCNA (Dietrich 1993) to further investigate hepatocyte proliferation in response to TRI exposure and found that PCNA mRNA increased with TRI exposure in mPPAR?
Positive_regulation (increased) of PCNA in hepatocyte
13) Confidence 0.14 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.57 Pain Relevance 0
The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle.
Positive_regulation (accumulation) of cyclin
14) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.07 Pain Relevance 0.03
In cirrhotic patients, a high level of PCNA immunolabeling is associated with an increased risk of HCC [17,18], and in HCC, high PCNA values are associated with poor prognosis [17].
Positive_regulation (level) of PCNA associated with cirrhosis and hepatocellular cancer
15) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.99 Pain Relevance 0
These data suggest that the residual tumor cells facilitate tumor growth and metastasis through induction of overexpression of PCNA, MMP-9, VEGF, HGF and IL-6.
Positive_regulation (induction) of PCNA in HGF associated with residual neoplasm, cancer and metastasis
16) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 1.26 Pain Relevance 0
Secondly, residual hepatic VX2 carcinoma might facilitate rapid tumor progression through induction of overexpression of multiple molecular factors, such as PCNA, MMP-9, VEGF, HGF and IL-6.


Positive_regulation (induction) of PCNA in HGF associated with cancer and carcinoma
17) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.73 Pain Relevance 0
Residual hepatic VX2 carcinoma could facilitate its rapid progression through inducing overexpression of several molecular factors, such as PCNA, MMP-9, VEGF, HGF and IL-6.



Positive_regulation (inducing) of PCNA in HGF associated with carcinoma
18) Confidence 0.09 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2917410 Disease Relevance 0.63 Pain Relevance 0.03
Secondly, residual hepatic VX2 carcinoma might facilitate rapid tumor progression through induction of overexpression of multiple molecular factors, such as PCNA, MMP-9, VEGF, HGF and IL-6.


Positive_regulation (overexpression) of PCNA in HGF associated with cancer and carcinoma
19) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.73 Pain Relevance 0
in proliferation, assessed by PCNA, an increase in p27kip1 and a
Positive_regulation (increase) of PCNA
20) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.58 Pain Relevance 0

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