INT85080

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 4.51
Pain Relevance 19.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pons 11
medulla 9
spinal cord 4
brain 4
forebrain 4
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 5 100.00 Very High Very High Very High
opioid receptor 99 99.98 Very High Very High Very High
agonist 47 99.98 Very High Very High Very High
Kappa opioid receptor 7 99.90 Very High Very High Very High
narcan 13 99.84 Very High Very High Very High
antinociception 22 99.80 Very High Very High Very High
orphanin 12 99.80 Very High Very High Very High
midbrain 10 99.68 Very High Very High Very High
antagonist 14 99.66 Very High Very High Very High
Kinase C 8 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 51 98.96 Very High Very High Very High
Nociception 5 98.68 Very High Very High Very High
Urological Neuroanatomy 3 87.72 High High
Toxicity 3 86.92 High High
Neuropathic Pain 6 86.88 High High
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the increase in the G-protein activation induced by M-6-G was eliminated in sciatic nerve ligation.
Positive_regulation (increase) of Positive_regulation (activation) of G-protein in sciatic nerve associated with sciatic nerve
1) Confidence 0.50 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17593930 Disease Relevance 0.43 Pain Relevance 2.85
Furthermore, exposure to bisphenol-A during either organogenesis or lactation also produced an up-regulation of dopamine receptor function to activate G-protein in the mouse limbic forebrain.
Positive_regulation (up-regulation) of Positive_regulation (activate) of G-protein in forebrain associated with dopamine receptor
2) Confidence 0.36 Published 2007 Journal Addict Biol Section Abstract Doc Link 17508988 Disease Relevance 0.16 Pain Relevance 0.22
Additionally, the treatment with bisphenol-A produced an up-regulation of dopamine receptor function to activate G-protein in the mouse limbic forebrain, which is thought to play a critical role for hyperlocomotion and rewarding effects by drugs of abuse.
Positive_regulation (up-regulation) of Positive_regulation (activate) of G-protein in forebrain associated with dopamine receptor
3) Confidence 0.34 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16678967 Disease Relevance 0.07 Pain Relevance 0.42
Intermittent morphine treatment results in the upregulation of dopamine receptor-regulated G-protein activation in the mouse limbic forebrain, whereas this treatment causes the downregulation of GABA(B) receptor function to activate G-protein in the mouse lower midbrain.
Positive_regulation (upregulation) of Positive_regulation (activation) of G-protein in midbrain associated with gaba, dopamine receptor, midbrain and morphine
4) Confidence 0.29 Published 2003 Journal Addict Biol Section Abstract Doc Link 13129834 Disease Relevance 0 Pain Relevance 0.94
The effects of repeated s.c. administrations of an mu-opioid receptor antagonist naloxone on the G-protein activation induced by mu-opioid receptor agonists [D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO), endomorphin-1 and endomorphin-2 in the mouse spinal cord was studied, monitoring guanosine-5'-o-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding.
Positive_regulation (induced) of Positive_regulation (activation) of G-protein in spinal cord associated with antagonist, agonist, narcan, enkephalin, opioid receptor and spinal cord
5) Confidence 0.11 Published 2001 Journal Brain Res. Section Abstract Doc Link 11549382 Disease Relevance 0 Pain Relevance 0.67
Up-regulation of mu-opioid receptor-mediated G-protein activation in protein kinase Cgamma knockout mice following repeated naloxone treatment.
Positive_regulation (mediated) of Positive_regulation (activation) of G-protein associated with targeted disruption, narcan and opioid receptor
6) Confidence 0.11 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12566163 Disease Relevance 0.10 Pain Relevance 0.78
The present results suggest that MOR that is created from the sequences encoded with exons 2 and 3 of the MOR gene, as has been previously observed in studies of mice lacking exon 1 of this gene, may be another critical target for the activation of G-protein by MOR agonists in the mouse pons/medulla.
Positive_regulation (created) of Positive_regulation (activation) of G-protein in pons associated with medulla and agonist
7) Confidence 0.08 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12459506 Disease Relevance 0.33 Pain Relevance 0.56
Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla.
Positive_regulation (mediated) of Positive_regulation (activation) of G-protein in pons associated with medulla, kinase c, mu opioid receptor and opioid receptor
8) Confidence 0.08 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12359310 Disease Relevance 0.13 Pain Relevance 0.76
The G-protein activation induced by mu-opioid receptor agonists in the pons/medulla membrane obtained from mice lacking exons 2 and 3 of mu-opioid receptor gene (MOR (Exons 2 and 3)-knockout (KO) mice) was investigated by monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding.
Spec (investigated) Positive_regulation (induced) of Spec (investigated) Positive_regulation (activation) of G-protein in medulla associated with targeted disruption, medulla, agonist and opioid receptor
9) Confidence 0.08 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12459506 Disease Relevance 0.25 Pain Relevance 0.48
The G-protein activation induced by mu-opioid receptor agonists was determined in spinal cord membranes from two types of mu-opioid receptor knockout mice: mice with a disruption of exon 1 (MOR (Exon 1)-KO) or exons 2 and 3 (MOR (Exons 2 and 3)-KO) of the mu-opioid receptor gene.
Positive_regulation (induced) of Positive_regulation (activation) of G-protein in spinal cord associated with targeted disruption, agonist, opioid receptor and spinal cord
10) Confidence 0.06 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14737012 Disease Relevance 0.10 Pain Relevance 0.63
These data support the notion that there are limited physiological mu-opioid receptor reserves for inducing G-protein activation in the pons/medulla and for the nociceptive modulation induced by the central administration of endomorphin-1 and -2.
Positive_regulation (inducing) of Positive_regulation (activation) of G-protein in medulla associated with nociception, medulla and opioid receptor
11) Confidence 0.06 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.54 Pain Relevance 1.11
The mu-opioid receptors are the principal molecular targets for endomorphin-induced G-protein activation in the pons/medulla and the antinociception caused by the intracerebroventricular administration of mu-opioid agonists.
Positive_regulation (endomorphin-induced) of Positive_regulation (activation) of G-protein in pons associated with antinociception, medulla, mu agonist, mu opioid receptor and intracerebroventricular
12) Confidence 0.06 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.54 Pain Relevance 1.29
Heterologous mu-opioid receptor adaptation by repeated stimulation of kappa-opioid receptor: up-regulation of G-protein activation and antinociception.
Positive_regulation (regulation) of Positive_regulation (activation) of G-protein associated with antinociception, analgesic, kappa opioid receptor and opioid receptor
13) Confidence 0.06 Published 2003 Journal J. Neurochem. Section Title Doc Link 12753076 Disease Relevance 0 Pain Relevance 1.13
The present results suggest that MOR that is created from the sequences encoded with exons 2 and 3 of the MOR gene, as has been previously observed in studies of mice lacking exon 1 of this gene, may be another critical target for the activation of G-protein by MOR agonists in the mouse pons/medulla.
Positive_regulation (created) of in medulla Positive_regulation (activation) of G-protein in pons associated with medulla and agonist
14) Confidence 0.03 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12459506 Disease Relevance 0.33 Pain Relevance 0.56
Downstream signaling required G-protein activation and phosphorylation as intracellularly administered GDP-beta-S [guanosine 5'-O-(2-thiodiphosphate], protein kinase A inhibitors, and an A-kinase anchoring protein inhibitor significantly blocked serotonergic facilitation of TRPV1 function; 5-HT2 receptor-mediated facilitation was also inhibited by a PKC inhibitor.
Positive_regulation (required) of Positive_regulation (activation) of G-protein
15) Confidence 0.03 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509739 Disease Relevance 0.07 Pain Relevance 0.39
Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla.
Positive_regulation (mediated) of in medulla Positive_regulation (activation) of G-protein in pons associated with medulla, kinase c, mu opioid receptor and opioid receptor
16) Confidence 0.03 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12359310 Disease Relevance 0.13 Pain Relevance 0.76
The G-protein activation induced by mu-opioid receptor agonists in the pons/medulla membrane obtained from mice lacking exons 2 and 3 of mu-opioid receptor gene (MOR (Exons 2 and 3)-knockout (KO) mice) was investigated by monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding.
Spec (investigated) Positive_regulation (induced) of in pons Spec (investigated) Positive_regulation (activation) of G-protein in medulla associated with targeted disruption, medulla, agonist and opioid receptor
17) Confidence 0.03 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12459506 Disease Relevance 0.25 Pain Relevance 0.48
Agonist-induced G-protein activation via NOP receptors was studied in [(35)S]GTPgammaS binding stimulation assays by the use of both native brain tissue preparations and membranes from cultured CHO cells expressing recombinant nociceptin receptors.
Positive_regulation (induced) of Positive_regulation (activation) of G-protein in brain associated with orphanin and agonist
18) Confidence 0.02 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15491792 Disease Relevance 0 Pain Relevance 0.92
These data support the notion that there are limited physiological mu-opioid receptor reserves for inducing G-protein activation in the pons/medulla and for the nociceptive modulation induced by the central administration of endomorphin-1 and -2.
Positive_regulation (inducing) of in pons Positive_regulation (activation) of G-protein in medulla associated with nociception, medulla and opioid receptor
19) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.54 Pain Relevance 1.11
Concomitant intrathecal administration of a specific PKC inhibitor Ro-32-0432 with DAMGO blocked the attenuation of DAMGO-induced G-protein activation that was caused by chronic DAMGO treatment.
Positive_regulation (induced) of Positive_regulation (activation) of G-protein associated with kinase c and intrathecal
20) Confidence 0.02 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.91

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