INT85084

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Context Info
Confidence 0.73
First Reported 1999
Last Reported 2010
Negated 7
Speculated 1
Reported most in Body
Documents 66
Total Number 69
Disease Relevance 42.56
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hepatocytes 4
plasma 2
skin 2
lung 2
stem cell 2
KRT19 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 49 99.66 Very High Very High Very High
Inflammation 183 99.18 Very High Very High Very High
aspirin 132 91.88 High High
chemokine 8 89.12 High High
imagery 10 87.96 High High
abdominal pain 2 84.20 Quite High
palliative 3 81.88 Quite High
Paracetamol 8 70.64 Quite High
metalloproteinase 27 67.28 Quite High
Pain 8 64.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 2757 100.00 Very High Very High Very High
Adenocarcinoma 1303 100.00 Very High Very High Very High
Targeted Disruption 475 100.00 Very High Very High Very High
Carcinoma 567 99.96 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 21 99.84 Very High Very High Very High
Pheochromocytoma 99 99.78 Very High Very High Very High
Mesothelioma 100 99.72 Very High Very High Very High
Cholangiocarcinoma 58 99.72 Very High Very High Very High
Breast Cancer 450 99.68 Very High Very High Very High
Cleidocranial Dysplasia 148 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CK19 co-expressed with HepPar1, c-kit, and alpha-fetoprotein (AFP) in parenchymal cells in massive necrosis.
Gene_expression (co-expressed) of CK19 in parenchymal cells associated with necrosis
1) Confidence 0.73 Published 1999 Journal Hepatology Section Abstract Doc Link 10573521 Disease Relevance 0.39 Pain Relevance 0.16
Immunohistochemically, the neoplasm coexpressed vimentin and epithelial antigens (AE1/AE3, Cam 5.2, CK34betaE12, CK19 and EMA), most of them showing a peculiar immunostaining pattern in relation to the globular inclusions.
Gene_expression (coexpressed) of CK19 associated with cancer
2) Confidence 0.73 Published 2008 Journal APMIS Section Abstract Doc Link 19132990 Disease Relevance 1.12 Pain Relevance 0.13
Sequencing of the Keratin 19 (KRT19), 5?
Gene_expression (Sequencing) of KRT19
3) Confidence 0.63 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 0.41 Pain Relevance 0
Out of the 21 candidate novel phaeochromocytoma TSGs, 19 (excepting KRT19 and CST6) were completely unmethylated in the three neuroblastoma cell lines and in adult normal adrenal DNA.
Neg (excepting) Gene_expression (excepting) of KRT19 associated with neuroblastoma and pheochromocytoma
4) Confidence 0.63 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 0.41 Pain Relevance 0
Sequencing of the Keratin 19 (KRT19), 5?
Gene_expression (Sequencing) of Keratin 19
5) Confidence 0.63 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 0.41 Pain Relevance 0
Benoy et al (CK19PCR, mamPCR) showed worse OS in patients with CK19 and mam expression in BM but not in PBL [13].
Gene_expression (expression) of CK19
6) Confidence 0.63 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.71 Pain Relevance 0
Out of seven cancer-associated gene-markers used to detect tumor cells in PBL and BM, CK19, muc1 and ErbB2 were not informative due to the high expression in normal control samples.


Gene_expression (expression) of CK19 associated with cancer
7) Confidence 0.62 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.51 Pain Relevance 0
Our study, in contradiction, suggested that CK19 has high expression level in normal control samples and is therefore not reliable detector of CTC.
Gene_expression (expression) of CK19
8) Confidence 0.62 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.67 Pain Relevance 0
Contained within each cluster are genes whose expression was previously associated with pancreatic adenocarcinoma, including keratin 19 (KRT19), anterior gradient 2 homolog (AGR2), v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), mesothelin (MSLN), and prostate stem cell antigen (PSCA) [5], [26]–[28].
Gene_expression (expression) of KRT19 in stem cell associated with adenocarcinoma and leukemia
9) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.08 Pain Relevance 0.03
Contained within each cluster are genes whose expression was previously associated with pancreatic adenocarcinoma, including keratin 19 (KRT19), anterior gradient 2 homolog (AGR2), v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), mesothelin (MSLN), and prostate stem cell antigen (PSCA) [5], [26]–[28].
Gene_expression (expression) of keratin 19 in stem cell associated with adenocarcinoma and leukemia
10) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.08 Pain Relevance 0.03
For this study we selected seven breast cancer-associated genes [mam, CEA, CK19, PIP, muc1, PSE, Erb (BM only) and EpCAM (PBL only)] known to be over-expressed in metastatic breast cancer compared to control lymph nodes [31,36,37].
Gene_expression (expressed) of CK19 in lymph nodes associated with breast cancer and advanced or metastatic breast cancer
11) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.66 Pain Relevance 0
The genes like CK19, muc1, PSE and EpCAM that show significant background expression in normal samples, loose its accuracy in tumor cell detection when Ficoll density gradient cell separation methodology is used.
Gene_expression (expression) of CK19 associated with cancer
12) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.62 Pain Relevance 0
In comparison, Benoy et al demonstrated 68% of concordance between PBL and BM samples using CK19 and 75% concordance between PBL and BM samples using mam gene [13].
Gene_expression (using) of CK19
13) Confidence 0.54 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.49 Pain Relevance 0
Thus, conventional (clear cell) RCCs express a simple keratin pattern of mainly K8/K18 together with variable, mostly minor expression of K19.
Gene_expression (expression) of K19 associated with renal cancer
14) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.81 Pain Relevance 0
The expression of K19 may be induced in certain epithelia that normally lack this keratin by pathological alterations.
Gene_expression (expression) of K19
15) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.72 Pain Relevance 0.03
Like other adenocarcinomas, most breast carcinomas constitutively express K8, K18 and K19 (Altmannsberger et al. 1986; Malzahn et al. 1998).
Gene_expression (express) of K19 associated with adenocarcinoma and breast cancer
16) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.90 Pain Relevance 0
Sections were stained routinely (H&E, trichrome, reticulin) as well as immunostained for detection of CK7, CK19, ?
Gene_expression (detection) of CK19
17) Confidence 0.44 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC166154 Disease Relevance 0.40 Pain Relevance 0.09
Chromophobe RCCs, on the other hand, typically express K7 (but little K19) in addition to K8/K18 (Thoenes et al. 1988).
Gene_expression (express) of K19 associated with renal cancer
18) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.93 Pain Relevance 0
Several studies suggest that the expression of K19 in these tumors may be correlated with a poor prognosis (Schmitt et al. 2007; La Rosa et al. 2007).


Gene_expression (expression) of K19 associated with cancer
19) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.22 Pain Relevance 0
One example for such application may be, in liver tumors, the distinction of hepatocellular carcinomas, which show little expression of K19, from cholangiocarcinomas and adenocarcinoma metastases, which strongly stain for this keratin (Balaton et al. 1988; Goldstein and Bosler 2006; see Table 3).
Neg (little) Gene_expression (expression) of K19 in liver associated with adenocarcinoma, liver cancer, cholangiocarcinoma, hepatocellular cancer and metastasis
20) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.45 Pain Relevance 0.04

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