INT85085

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 36
Total Number 39
Disease Relevance 30.08
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
Anatomy Link Frequency
smooth muscle 2
muscle 2
T cells 2
mononuclear cells 2
plasma 1
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 2 98.84 Very High Very High Very High
cytokine 119 98.80 Very High Very High Very High
Inflammation 155 97.04 Very High Very High Very High
substance P 10 94.48 High High
cva 7 86.24 High High
Dysuria 1 83.56 Quite High
agonist 7 82.48 Quite High
imagery 26 81.96 Quite High
pain pelvic 1 81.60 Quite High
abdominal pain 31 80.40 Quite High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 4 100.00 Very High Very High Very High
Apoptosis 236 99.92 Very High Very High Very High
Cancer 614 99.76 Very High Very High Very High
Myocardial Infarction 15 99.68 Very High Very High Very High
Gastrointestinal Stromal Tumor 742 99.48 Very High Very High Very High
Liposarcoma 36 98.12 Very High Very High Very High
Disease 396 97.92 Very High Very High Very High
Metastasis 51 97.28 Very High Very High Very High
Death 93 97.12 Very High Very High Very High
Diabetes Mellitus 95 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining demonstrated positive reactivity to C-kit protein, CD34, and ?
Positive_regulation (reactivity) of C-kit
1) Confidence 0.53 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2486266 Disease Relevance 1.28 Pain Relevance 0
Immunohistochemical staining revealed a strongly (+) reaction for c-kit, slight (+) for S-100, and no specific staining for CD34 and desmin.
Positive_regulation (reaction) of c-kit
2) Confidence 0.50 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2034569 Disease Relevance 1.26 Pain Relevance 0
More importantly, the authors reported finding KIT immunoreactive CD117 and CD34 cells within specimens of omentum [12].
Spec (finding) Positive_regulation (finding) of KIT
3) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2409333 Disease Relevance 0.69 Pain Relevance 0
More importantly, the authors reported finding KIT immunoreactive CD117 and CD34 cells within specimens of omentum [12].
Spec (finding) Positive_regulation (finding) of CD117
4) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2409333 Disease Relevance 0.69 Pain Relevance 0
More importantly, the authors reported finding KIT immunoreactive CD117 and CD34 cells within specimens of omentum [12].
Positive_regulation (immunoreactive) of KIT
5) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2409333 Disease Relevance 0.69 Pain Relevance 0
More importantly, the authors reported finding KIT immunoreactive CD117 and CD34 cells within specimens of omentum [12].
Positive_regulation (immunoreactive) of CD117
6) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2409333 Disease Relevance 0.69 Pain Relevance 0
Immunohistochemically, the tumor cells were positive for alpha-smooth muscle actin and muscle actin, and negative for KIT, CD34, and S-100 protein.
Positive_regulation (negative) of KIT in muscle associated with cancer
7) Confidence 0.49 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 17460456 Disease Relevance 1.11 Pain Relevance 0.07
In the immunoassay, the tumor cells stained strongly positive for SMA (Fig. 2) and negative for KIT, CD34, and S100.
Positive_regulation (negative) of KIT associated with cancer
8) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2615012 Disease Relevance 0.95 Pain Relevance 0
In addition, immunohistochemistry was performed for COX-2, the macrophage marker, CD68 (KP-1), and KIT (CD117).
Positive_regulation (performed) of KIT in macrophage
9) Confidence 0.49 Published 2003 Journal Hum. Pathol. Section Abstract Doc Link 14691908 Disease Relevance 0.72 Pain Relevance 0
In the decade following the landmark discovery of activating KIT mutation in GIST, much has been learned about this disease.
Positive_regulation (activating) of KIT associated with disease and gastrointestinal stromal tumor
10) Confidence 0.48 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.84 Pain Relevance 0
The majority of GISTs are usually positive for CD117 (near 95% of cases), CD34 (positive in 70–80% of cases), smooth muscle actin (positive in 40% of cases), PS 100 (positive near 5% of cases), and desmin (positive in approximately 2% of cases) [1-3].
Positive_regulation (positive) of CD117 in smooth muscle
11) Confidence 0.47 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2034569 Disease Relevance 0.97 Pain Relevance 0
However, the main function of CD117 is the activation of the cell proliferation.
Positive_regulation (activation) of CD117
12) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.85 Pain Relevance 0
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Positive_regulation (positive) of KIT in thyroid
13) Confidence 0.45 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.61 Pain Relevance 0.08
The tumor cells were positive for KIT, CD34, platelet-derived growth factor receptor alpha, and vimentin, but negative for alpha-smooth muscle actin, S100 protein, p53 protein, HMB45, and desmin.
Positive_regulation (positive) of KIT in platelet associated with cancer
14) Confidence 0.45 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19047911 Disease Relevance 0.78 Pain Relevance 0.12
As described above, the vast majority of GISTs are defined by mutations in KIT, which lead to constitutive ligand-independent activation of the KIT-RTK, and subsequent downstream signaling resulting in uncontrolled cell growth.
Neg (independent) Positive_regulation (activation) of KIT-RTK
15) Confidence 0.45 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.90 Pain Relevance 0
In this landmark publication, the group reported the finding of activating KIT mutations in a significant proportion of GISTs, with constitutive ligand-independent activation of the KIT-receptor tyrosine kinase (RTK), and a near universal expression of KIT on immunohistochemistry.7 Corroborated by Kindblom and others, it was demonstrated that GIST cells were closely related to the interstitial cells of Cajal.8 This understanding provided the platform for accurate and uniform diagnoses of this uncommon tumor and the rational development and use of tyrosine kinase inhibitors (TKI) in the management of GIST.


Neg (independent) Positive_regulation (activation) of KIT-receptor in interstitial cells associated with cancer and gastrointestinal stromal tumor
16) Confidence 0.45 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.47 Pain Relevance 0
GIST in the pediatric age group is rare, accounting for less than 1% to 2% of all GIST cases.47 Although pediatric GISTs express KIT and display a high level of KIT activation, unique differences exist that distinguish them from adult GISTs, notably, the relative absence of KIT or PDGFRA mutations, with only less than 15% of cases harboring these mutations.3–4 In contrast, activating mutations in KIT or PDGFRA are found in more than 85% of adult GISTs.30 Recent reports suggest pediatric GISTs exhibit distinct gene-expression signatures4 and genetic progression mechanisms from adult GISTs.3 Consistent with the molecular profile of wild-type GISTs, most pediatric GIST cases respond less favorably to imatinib than adult KIT exon 11 mutant GISTs.
Positive_regulation (activation) of KIT associated with gastrointestinal stromal tumor
17) Confidence 0.45 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.50 Pain Relevance 0
cell precursors here, at 21 days of coculture, when c-kit and PDX-1 transcription factors are upregulated in a pancreatic neogenesis model.
Positive_regulation (upregulated) of c-kit
18) Confidence 0.44 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Likewise, an increase in PDX-1 and c-kit mRNA also was observed.
Positive_regulation (increase) of c-kit mRNA
19) Confidence 0.44 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Immunohistochemical staining was negative for CD117 and positive for S-100 protein.
Positive_regulation (negative) of CD117
20) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887402 Disease Relevance 0.91 Pain Relevance 0.08

General Comments

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