INT8512

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Context Info
Confidence 0.65
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 7.98
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PREP) peptidase activity (PREP) nucleus (PREP)
cytoplasm (PREP)
Anatomy Link Frequency
chondrocytes 3
fibroblasts 2
neurons 1
brush 1
neural 1
PREP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 824 99.72 Very High Very High Very High
rheumatoid arthritis 38 98.12 Very High Very High Very High
Enkephalin 4 82.72 Quite High
Opioid 2 75.00 Quite High
Inflammatory stimuli 8 73.92 Quite High
Inflammation 140 54.24 Quite High
Sciatica 4 50.00 Quite Low
epidural 2 50.00 Quite Low
backache 1 50.00 Quite Low
Arthritis 64 19.24 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 832 99.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 376 98.64 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.56 Very High Very High Very High
Rheumatoid Arthritis 44 98.12 Very High Very High Very High
Idiopathic Thrombocytopenic Purpura 8 97.52 Very High Very High Very High
Systemic Lupus Erythematosus 8 96.62 Very High Very High Very High
Autoimmune Disease 64 95.02 Very High Very High Very High
Pain 13 87.16 High High
Low Back Pain 2 85.84 High High
Sexually Transmitted Diseases 4 74.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A specimen obtained from the area using a cytology brush was processed by the Thin Prep technique.
Gene_expression (technique) of Prep in brush
1) Confidence 0.65 Published 2009 Journal Pain Pract Section Body Doc Link 19408363 Disease Relevance 0.17 Pain Relevance 0
Circumcision was described as a minor surgical procedure, and PREP as a medication that has to be taken every day, and both with 50% efficacy.
Gene_expression (procedure) of PREP
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912853 Disease Relevance 0.24 Pain Relevance 0
Participants were then asked about their initial commitment to PREP or circumcision using the following question: Are you ready to get circumcised (take PREP) to reduce your risk for getting HIV?
Gene_expression (take) of PREP associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912853 Disease Relevance 0.24 Pain Relevance 0
Circumcision and PREP were chosen for this population because they were novel HIV prevention interventions under investigation at the time of the study, and they presented very different implementation challenges.
Gene_expression (Circumcision) of PREP associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912853 Disease Relevance 0.52 Pain Relevance 0
Circumcision and PREP were chosen for this population because they were novel HIV prevention interventions under investigation at the time of the study, and they presented very different implementation challenges.
Gene_expression (chosen) of PREP associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912853 Disease Relevance 0.52 Pain Relevance 0
For this purpose, we selected 133 autoimmunity-related genes that were previously identified as being up- or down-regulated in PBMCs from patients with various autoimmune diseases (Fig. 3A and Supplementary Table S2), such as systemic lupus erythematosus (SLE),11 idiopathic thrombocytopenic purpura (ITP),11  rheumatoid arthritis (RA)12  and/or vasculitis.13  In addition, 12 genes from the group of PBMC-specific genes termed PREP (predominantly expressed in PBMC) genes, which are highly expressed in normal PBMCs but not in normal human fibroblasts,14  and 68 immunity-related genes known to be involved in immune regulation were also used.
Gene_expression (expressed) of PREP in fibroblasts associated with autoimmune disease, idiopathic thrombocytopenic purpura, rheumatoid arthritis, increased venous pressure under development and systemic lupus erythematosus
6) Confidence 0.39 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 1.11 Pain Relevance 0.10
For this purpose, we selected 133 autoimmunity-related genes that were previously identified as being up- or down-regulated in PBMCs from patients with various autoimmune diseases (Fig. 3A and Supplementary Table S2), such as systemic lupus erythematosus (SLE),11 idiopathic thrombocytopenic purpura (ITP),11  rheumatoid arthritis (RA)12  and/or vasculitis.13  In addition, 12 genes from the group of PBMC-specific genes termed PREP (predominantly expressed in PBMC) genes, which are highly expressed in normal PBMCs but not in normal human fibroblasts,14  and 68 immunity-related genes known to be involved in immune regulation were also used.
Gene_expression (expressed) of PREP in fibroblasts associated with autoimmune disease, idiopathic thrombocytopenic purpura, rheumatoid arthritis, increased venous pressure under development and systemic lupus erythematosus
7) Confidence 0.39 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 1.11 Pain Relevance 0.10
, PHA (phytohemagglutinin) and PE and the production of IL-2 was quantified using the IL-2-specific ELISA according to the instructions of the manufacturer (R&D Systems).
Gene_expression (production) of PE
8) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.15 Pain Relevance 0.07
PE is produced in a two-step process: 1) extraction of fruit residue after pressing for juice and 2) solid-phase extraction to produce a powder with a high concentration of polyphenols.
Gene_expression (produced) of PE
9) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.19 Pain Relevance 0.06
Primary human OA chondrocytes (70 to 80% confluent) were pretreated with PE and then stimulated with IL-1?
Gene_expression (pretreated) of PE in chondrocytes associated with osteoarthritis
10) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.77 Pain Relevance 0.38
PE pretreated and IL-1?
Gene_expression (pretreated) of PE
11) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.66 Pain Relevance 0.33
-induced activation of MKK3 and MKK6 in human OA chondrocytes, cells were pretreated with PE (6.25 to 100 ?
Gene_expression (pretreated) of PE in chondrocytes associated with osteoarthritis
12) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.76 Pain Relevance 0.35
Our results demonstrate that PE suppresses the IL-1?
Gene_expression (suppresses) of PE
13) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.74 Pain Relevance 0.37
Activation and DNA binding activity of RUNX-2 in human OA chondrocytes pretreated with PE (2 h) and then stimulated with IL-1?
Gene_expression (pretreated) of PE in chondrocytes associated with osteoarthritis
14) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.37 Pain Relevance 0.19
Based on this data the maximum concentration of PE used in these studies was 100 ?
Gene_expression (used) of PE
15) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.43 Pain Relevance 0.21
The female-typical plexus of m-ENK fibers in the pePOA is not expressed prepubertally, but first becomes evident during the late peri-pubertal period (usually by 40 days of age).
Neg (not) Gene_expression (expressed) of pePOA
16) Confidence 0.02 Published 1988 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 3069240 Disease Relevance 0 Pain Relevance 0.16
These results demonstrate that while the sexually dimorphic m-ENK system of the pePOA is not normally expressed prepubertally, the neural substrate is nevertheless in place and capable of being activated by exposure to exogenous estradiol.
Neg (not) Gene_expression (expressed) of pePOA in neural
17) Confidence 0.02 Published 1988 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 3069240 Disease Relevance 0 Pain Relevance 0.13
Moreover, because expression of the ENK-ir pePOA fiber plexus is estrogen-sensitive in the female, these results suggest strongly that estrogen may regulate these neurons both pre- and postsynaptically.
Gene_expression (expression) of pePOA in neurons
18) Confidence 0.00 Published 1992 Journal Brain Res. Section Abstract Doc Link 1374283 Disease Relevance 0 Pain Relevance 0.05

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