INT85126

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 12.12
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
neuronal 1
endothelial cells 1
brains 1
HGF 1
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 24 99.90 Very High Very High Very High
Osteoarthritis 103 99.12 Very High Very High Very High
aspirin 6 98.86 Very High Very High Very High
antagonist 39 97.82 Very High Very High Very High
Kinase C 7 97.42 Very High Very High Very High
opiate 7 97.08 Very High Very High Very High
metalloproteinase 11 96.76 Very High Very High Very High
chemokine 8 96.40 Very High Very High Very High
fluoxetine 1 95.92 Very High Very High Very High
cytokine 45 94.64 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 5 99.84 Very High Very High Very High
Osteoarthritis 104 99.12 Very High Very High Very High
Hepatocellular Cancer 13 99.12 Very High Very High Very High
Rheumatoid Arthritis 341 99.02 Very High Very High Very High
Apoptosis 59 98.96 Very High Very High Very High
Neuroblastoma 220 98.42 Very High Very High Very High
Disease 34 98.08 Very High Very High Very High
Urological Neuroanatomy 3 95.08 Very High Very High Very High
INFLAMMATION 52 91.36 High High
Colorectal Cancer 5 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This in turn may be of value in the development of MKK inhibitors for the treatment of OA and other degenerative diseases.


Negative_regulation (inhibitors) of MKK associated with disease and osteoarthritis
1) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.80 Pain Relevance 0.43
The purpose of the present study was to investigate whether 5-hydroxytryptamine (5-HT, serotonin) affects migration of vascular endothelial cells. 5-HT significantly enhanced migration of human aortic endothelial cells (HAECs), and this enhancement was completely inhibited by GR 55562, a 5-HT1 receptor antagonist, and fluoxetine, a 5-HT transporter inhibitor, but was not affected by ketanserin, a 5-HT2 receptor antagonist. 5-HT stimulation increased RhoA and ERK activity of HAECs, and inhibitors of RhoA (Y-27632 and H-1152) and inhibitors of MEK (U0126 and PD98059) abolished the 5-HT-induced increase in migration velocity.
Negative_regulation (inhibitors) of MEK in endothelial cells associated with antagonist, serotonin and fluoxetine
2) Confidence 0.21 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16310780 Disease Relevance 0.09 Pain Relevance 0.24
MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindac.
Negative_regulation (inhibition) of MEK associated with pancreatic cancer
3) Confidence 0.13 Published 2003 Journal Pancreas Section Title Doc Link 14576498 Disease Relevance 0.19 Pain Relevance 0.08
These compounds induced phosphorylation of extracellular signal-regulated kinase1/2 (Erk1/2), whereas a dominant-negative inhibitor of mitogen-activate protein kinase kinase (MEK) 1 blocked the induction of ATF3.
Negative_regulation (inhibitor) of MEK
4) Confidence 0.11 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.11 Pain Relevance 0
U0126, a specific inhibitor of the ERK-activating kinases MEK-1/-2, prevented the activation of ERK induced by NS-398 and blocked the increase in COX-2 protein expression seen when HT29 cells were treated with NS-398 alone.
Negative_regulation (inhibitor) of MEK
5) Confidence 0.09 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.62 Pain Relevance 0.26
The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.
Negative_regulation (inhibitor) of MEK
6) Confidence 0.09 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.33
MEK inhibitors, PD98059 and U-0126, which inhibited ERK phosphorylation were shown to elevate 15-PGDH levels very significantly.
Negative_regulation (inhibitors) of MEK
7) Confidence 0.09 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.54 Pain Relevance 0.44
A specific MAPK/ERK kinase (MEK) inhibitor, PD 098059, could induce apoptosis and eliminate the protective effect of IL-3, IL-5 and GM-CSF against NaSal-induced apoptosis in EoL-1 cells.
Negative_regulation (inhibitor) of MEK associated with apoptosis
8) Confidence 0.09 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 0.83 Pain Relevance 0.51
Therefore, our results provide preclinical support for a combined chemotherapeutic approach with selective NSAIDs and MEK inhibitors for the treatment of hepatocellular carcinoma.
Negative_regulation (inhibitors) of MEK associated with hepatocellular cancer and cinod
9) Confidence 0.08 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.60 Pain Relevance 0.23
Notably, pronounced downregulations of phosphorylated MEK (85%) and ERK1/2 (pERK1: 81%; pERK2: 80%) were quantitated in brains of opiate addicts.
Negative_regulation (downregulations) of MEK in brains associated with opiate
10) Confidence 0.07 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15198681 Disease Relevance 0.47 Pain Relevance 0.86
Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.
Negative_regulation (inhibition) of MEK associated with kinase c
11) Confidence 0.06 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.44 Pain Relevance 0.24
Addition of aspirin or NS-398, similar to PD98059, which acts as a specific inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK), an upstream kinase regulating extracellular signal-regulated kinase (ERK)1/2, abrogated such actions of HGF without affecting cell viability.
Negative_regulation (inhibitor) of MEK in HGF associated with aspirin
12) Confidence 0.04 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.56 Pain Relevance 0.49
Both U0126 and PD98059 are MEK inhibitors, and both are useful in probing the functions of MEK in a variety of biological processes, particularly those involving mitogen-activated protein kinase (MAP kinase/ERK) activation [39].
Negative_regulation (inhibitors) of MEK
13) Confidence 0.03 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933444 Disease Relevance 0.40 Pain Relevance 0
The precise action mechanisms of U0126 and PD98059 as MEK inhibitors, and in particular as ERK inhibitors, remain a matter of some controversy.
Negative_regulation (inhibitors) of MEK
14) Confidence 0.03 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933444 Disease Relevance 0.36 Pain Relevance 0
This study is, to the best of our knowledge, the first to demonstrate that the specific inhibitors of the MEK/ERK pathway, U0126 and PD98059, exert differential effects on the ERK phosphorylation induced by RA or DLK1 knockdown.
Negative_regulation (inhibitors) of MEK associated with rheumatoid arthritis
15) Confidence 0.03 Published 2010 Journal Nutrition Research and Practice Section Abstract Doc Link PMC2933444 Disease Relevance 1.28 Pain Relevance 0.05
Moreover, the synergistic effect in HMEEC cells was inhibited by the p38 inhibitor (SB203580), but not by the MEK inhibitor (PD98059) (Figure 4).
Neg (not) Negative_regulation (inhibitor) of MEK
16) Confidence 0.03 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.68 Pain Relevance 0.03
The MEK/ERK inhibitor U0126 completely inhibited neuronal differentiation induced by both RA and DLK1 knockdown, whereas PD98059 partially blocked neuronal differentiation.
Negative_regulation (inhibitor) of MEK in neuronal associated with rheumatoid arthritis
17) Confidence 0.02 Published 2010 Journal Nutrition Research and Practice Section Abstract Doc Link PMC2933444 Disease Relevance 1.55 Pain Relevance 0.04
Additionally, in order to assess the signal pathway of neuroblastoma differentiation induced by RA and DLK1 knockdown, treatment with the specific MEK/ERK inhibitors, U0126 and PD 98059, was applied to differentiated neuroblastoma cells.
Negative_regulation (inhibitors) of MEK associated with neuroblastoma and rheumatoid arthritis
18) Confidence 0.02 Published 2010 Journal Nutrition Research and Practice Section Abstract Doc Link PMC2933444 Disease Relevance 1.58 Pain Relevance 0.04
Contrariwise, other authors have reported that hydralazine decreases DNA methyltransferase 1 and 3a expression in a similar manner to PD98059, a Mitogen-activated protein kinase kinase (MEK) inhibitor, this suggesting that hydralazine does not directly inhibit DNA methyltransferase enzymatic activity [173].
Negative_regulation (inhibitor) of MEK
19) Confidence 0.02 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.85 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox