INT85130

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Context Info
Confidence 0.27
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.37
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL5) extracellular region (IL5)
Anatomy Link Frequency
apoptotic cell 1
eosinophils 1
IL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 269 100.00 Very High Very High Very High
Inflammation 286 99.82 Very High Very High Very High
Multiple sclerosis 141 99.16 Very High Very High Very High
Inflammatory mediators 6 99.16 Very High Very High Very High
Morphine 9 98.76 Very High Very High Very High
Arthritis 2 92.56 High High
adenocard 6 87.44 High High
agonist 62 87.36 High High
vagus nerve 2 85.56 High High
imagery 27 84.80 Quite High
Disease Link Frequency Relevance Heat
Asthma 760 100.00 Very High Very High Very High
INFLAMMATION 308 99.82 Very High Very High Very High
Hypersensitivity 84 99.56 Very High Very High Very High
Demyelinating Disease 155 99.16 Very High Very High Very High
Apoptosis 28 98.52 Very High Very High Very High
Death 16 97.92 Very High Very High Very High
Strongyloidiasis 56 96.96 Very High Very High Very High
Diabetes Mellitus 3 96.32 Very High Very High Very High
Cancer 67 94.60 High High
Cytomegalovirus Infection 21 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Haematopoietic cytokines such as IL-3, IL-5 and GM-CSF not only activate eosinophils but also prolong their life span by inhibiting their apoptotic cell death.
Regulation (prolong) of IL-5 in apoptotic cell associated with apoptosis, death and cytokine
1) Confidence 0.27 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 0.51 Pain Relevance 0.28
However, the IL-5 response was reduced in S. stercoralis and HTLV-1 co-infected patients (10 vs 299 pg/ml respectively, p?
Regulation (response) of IL-5
2) Confidence 0.16 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.17 Pain Relevance 0.04
Interleukin-5 responses to Strongyloides antigen
Regulation (responses) of Interleukin-5
3) Confidence 0.16 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.28 Pain Relevance 0.03
It contains two modified phosphorothioate anti-sense oligonucleotides designed to inhibit allergic inflammation by down-regulating human CCR3 and the common beta-chain of IL-3, IL-5 and GM CSF.
Regulation (regulating) of IL-5 associated with inflammation and hypersensitivity
4) Confidence 0.15 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.71 Pain Relevance 0.05
, interleukin (IL)-2, IL-4, IL-5 and IL-10 were measured in supernatants using a cytometric bead array (BD Biosciences).
Regulation (measured) of IL-5
5) Confidence 0.12 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.38 Pain Relevance 0.20
Thus, the lack of efficacy of anti-IL-5 on AHR via granule protein inhibition was incompletely understood.
Regulation (efficacy) of IL-5
6) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.74 Pain Relevance 0.03
Because of the importance of Th-2 cytokines, IL-4, IL-5, IL-9, and IL-13, strategies aimed at inhibiting their production or effects have been tried in human clinical trials (Table).
Regulation (importance) of IL-5 associated with cytokine
7) Confidence 0.09 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.66 Pain Relevance 0.41
, IL-4, IL-5, IL-8, RANTES and eotaxins, thought to be important in asthma pathogenesis, are regulated through activation of p38 MAPK. p38 MAPK can affect the transcription of these genes but also has major effects on mRNA stability.
Regulation (regulated) of IL-5 associated with asthma
8) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.91 Pain Relevance 0.44
In an animal model of asthma there is increased IL-19 expression and transfer of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13, however, IL-19 up-regulated IL-13 in “asthmatic” mice [260].
Neg (not) Regulation (regulated) of IL-5 associated with asthma
9) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.55 Pain Relevance 0.21
We found that morphine significantly promoted IL-4 and IL-13 production but did not alter IL-5 or IFN-gamma.
Neg (not) Regulation (alter) of IL-5 associated with morphine
10) Confidence 0.08 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.67 Pain Relevance 0.87
Two patients had interferon-gamma predominant responses and 3 had IL-5 predominant responses.
Regulation (responses) of IL-5
11) Confidence 0.07 Published 2007 Journal J. Immunother. Section Abstract Doc Link 17471169 Disease Relevance 0.99 Pain Relevance 0.14
Many elements of the allergic reaction, including the production of IgE antibodies and the recruitment and activation of eosinophils, depend on Type 2 cytokines, such as IL-4, IL-5, and IL-13.
Regulation (depend) of IL-5 in eosinophils associated with hypersensitivity and cytokine
12) Confidence 0.07 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.19 Pain Relevance 0.52
Increased intracellular IL-5 and IL-10 and decreased intracellular TNF-?
Regulation (intracellular) of IL-5
13) Confidence 0.05 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.56 Pain Relevance 0.29
Soluble IL-5?
Regulation (Soluble) of IL-5
14) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.06 Pain Relevance 0.03

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