INT85142

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Context Info
Confidence 0.26
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.30
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Gtf2i) nucleus (Gtf2i) embryo development (Gtf2i)
DNA binding (Gtf2i) molecular_function (Gtf2i) cellular_component (Gtf2i)
Anatomy Link Frequency
neuronal 1
paw 1
postsynaptic membranes 1
dorsal horn 1
gracile nucleus 1
Gtf2i (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 2 99.46 Very High Very High Very High
Sciatic nerve 4 99.32 Very High Very High Very High
Dorsal horn 73 99.20 Very High Very High Very High
Spinal cord 9 97.56 Very High Very High Very High
Thalamus 3 96.84 Very High Very High Very High
nMDA receptor 2 96.48 Very High Very High Very High
Anterior cingulate cortex 3 95.44 Very High Very High Very High
Glutamate receptor 4 94.84 High High
Glutamate 5 92.72 High High
Inflammation 41 90.64 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 99.48 Very High Very High Very High
Pressure And Volume Under Development 2 99.18 Very High Very High Very High
Neuroleptic Malignant Syndrome 9 94.00 High High
INFLAMMATION 35 90.64 High High
Nervous System Injury 5 88.20 High High
Pain 35 86.04 High High
Nociception 5 83.20 Quite High
Dyspepsia 1 75.00 Quite High
Hyperalgesia 9 72.04 Quite High
Congenital Anomalies 1 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine inhibited only the Fos-LI expression in the posterior cutaneous (PC) nerve territory of laminae I-II, but not in the sciatic nerve (SC) territory, laminae III-IV nor the gracile nucleus.
Gene_expression (expression) of I-II in gracile nucleus associated with sciatic nerve and morphine
1) Confidence 0.26 Published 1999 Journal Brain Res. Section Abstract Doc Link 10575103 Disease Relevance 0.27 Pain Relevance 0.82
All glutamatergic postsynaptic membranes in laminae I-II expressed AMPA receptors, and most of them (96%) were also immunoreactive for the NR1 subunit of NMDA receptors.
Gene_expression (expressed) of I-II in postsynaptic membranes associated with nmda receptor
2) Confidence 0.08 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18815255 Disease Relevance 0.17 Pain Relevance 0.43
Immunohistochemistry analysis demonstrated that CRD elevated p-ERK and c-fos expression in the dorsal root ganglia (DRG), laminae I-II of the lumbosacral dorsal horn, thalamic nucleus central medial (CM), paraventricular thalamic nucleus (PV), and anterior cingulate cortex (ACC).
Gene_expression (expression) of I-II in dorsal horn associated with dorsal horn and anterior cingulate cortex
3) Confidence 0.05 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 18649147 Disease Relevance 0.84 Pain Relevance 0.68
Treatment with DON reduced hind paw swelling by approximately 13% and suppressed Fos expression in the laminae I-II by approximately 54%, but not the deep laminae.
Gene_expression (expression) of I-II in paw associated with pressure and volume under development
4) Confidence 0.03 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20132864 Disease Relevance 0.54 Pain Relevance 0.67
We next investigated the potential overlap in neuronal population expressing these transcription regulators in laminae I-II.
Gene_expression (expressing) of I-II in neuronal
5) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.07
We compared the expression of P-MeCP2 with that of Zif268 and Fos in laminae I-II across all time points (Figure 3 and Figure 4; N = 3/5 at each time point).
Gene_expression (expression) of I-II
6) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.09

General Comments

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