INT85144

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 14
Total Number 18
Disease Relevance 6.41
Pain Relevance 9.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
superior 2
bladder 2
brain 1
face 1
nervous system 1
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 251 100.00 Very High Very High Very High
agonist 195 100.00 Very High Very High Very High
Cannabinoid receptor 110 100.00 Very High Very High Very High
Lasting pain 21 97.82 Very High Very High Very High
Bioavailability 13 97.44 Very High Very High Very High
Endocannabinoid 99 97.12 Very High Very High Very High
Potency 10 97.08 Very High Very High Very High
Spinal cord 20 95.92 Very High Very High Very High
Analgesic 45 95.84 Very High Very High Very High
qutenza 30 94.48 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 6 99.04 Very High Very High Very High
Schizophrenia 1 98.00 Very High Very High Very High
Pain 179 97.82 Very High Very High Very High
Anxiety Disorder 71 95.44 Very High Very High Very High
Overactive Bladder 100 94.80 High High
Arthritis 38 93.88 High High
INFLAMMATION 74 93.84 High High
Neuropathic Pain 50 93.28 High High
Vomiting 21 93.28 High High
Asthma 1 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the first time, we show that GW405833 selectively binds both rat and human CB2 receptors with high affinity, where it acts as a partial agonist (approximately 50% reduction of forskolin-mediated cAMP production compared to the full cannabinoid agonist, CP55,940).
CB2 Binding (binds) of associated with cannabinoid and agonist
1) Confidence 0.47 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814101 Disease Relevance 1.02 Pain Relevance 0.96
Ibu-am5 inhibited the binding of [3H]-CP55,940 to rat brain CB1 and human CB2 cannabinoid receptors more potently than ibuprofen, but the increase in potency was less than the corresponding increase in potency seen for inhibition of FAAH activity.
CB2 Binding (binding) of in brain associated with cannabinoid receptor and potency
2) Confidence 0.47 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17397826 Disease Relevance 0.14 Pain Relevance 0.34
We have localized cannabinoid receptor 2 protein in rat and mouse somatic sensory nervous system, using an antibody that recognizes mouse cannabinoid receptor 2.
cannabinoid receptor 2 Binding (recognizes) of in nervous system associated with cannabinoid receptor
3) Confidence 0.41 Published 2005 Journal Neuroscience Section Abstract Doc Link 16084654 Disease Relevance 0.28 Pain Relevance 0.54
We examined the interaction of both compounds with cannabinoid receptors (CB1 and CB2) and their efficacy in functional assays.
CB2 Spec (examined) Binding (interaction) of associated with cannabinoid receptor
4) Confidence 0.31 Published 2005 Journal Life Sci. Section Abstract Doc Link 15894337 Disease Relevance 0.06 Pain Relevance 0.32
This is also consistent with the moderate affinity of NA-glycine for the cannabinoid CB1 receptor [14], although NA-glycine's affinity for cannabinoid CB2 receptor remains to be determined.
cannabinoid CB2 receptor Binding (affinity) of associated with cannabinoid
5) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2042976 Disease Relevance 0.58 Pain Relevance 1.11
Expression pattern of CB1, CB2 and TRPV1 receptor - Days 8 to 10 of pregnancy
CB2 Binding (pattern) of
6) Confidence 0.28 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
Anandamide is a nonselective ligand that binds to both CB1 and CB2 cannabinoid G-protein-coupled receptors.
CB2 Binding (binds) of associated with cannabinoid
7) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794504 Disease Relevance 0.54 Pain Relevance 0.81
Two unsubstituted indoles ( 5, 32) were the starting points for an investigation of the effect of indole ring substitutions on CB 2 and CB 1 binding affinities and activity in a CB 2 in vitro functional assay.
CB 2 Binding (affinities) of
8) Confidence 0.26 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18311894 Disease Relevance 0 Pain Relevance 0.27
CB2 agonists are probably acting through several mechanisms and thus CB2 represents an interesting and promising target in the chronic pain field.
CB2 Binding (acting) of associated with lasting pain and agonist
9) Confidence 0.25 Published 2009 Journal J. Soc. Biol. Section Abstract Doc Link 19358815 Disease Relevance 0.85 Pain Relevance 1.31
The localization of CB2 receptor with nerves argues for a role of CB2 in bladder afferent signals which can be best demonstrated by cystometric studies.
CB2 Binding (receptor) of in bladder
10) Confidence 0.24 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.22 Pain Relevance 0.21
The localization of CB2 receptor with nerves argues for a role of CB2 in bladder afferent signals which can be best demonstrated by cystometric studies.
CB2 Binding (role) of in bladder
11) Confidence 0.24 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.28 Pain Relevance 0.19
AJA has been efficacious in animal models of chronic pain by activation of the CB1 receptor with a superior therapeutic index compared to other CB compounds.[65] AJA binds to human CB1/CB2 receptors in vitro, with high affinity at human CB1 (Ki 6nM) as well as h CB2 (Ki 56 nM) receptors.[65] In a previous study, by our group, on systemic administration of AJA, the role of CB1/CB2 receptors in micturition was more evident in the irritated condition of bladder than in normal condition.[66]
CB2 Spec (evident) Binding (affinity) of in superior associated with lasting pain and overactive bladder
12) Confidence 0.24 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.45 Pain Relevance 0.63
AJA has been efficacious in animal models of chronic pain by activation of the CB1 receptor with a superior therapeutic index compared to other CB compounds.[65] AJA binds to human CB1/CB2 receptors in vitro, with high affinity at human CB1 (Ki 6nM) as well as h CB2 (Ki 56 nM) receptors.[65] In a previous study, by our group, on systemic administration of AJA, the role of CB1/CB2 receptors in micturition was more evident in the irritated condition of bladder than in normal condition.[66]
CB2 Spec (evident) Binding (binds) of in superior associated with lasting pain and overactive bladder
13) Confidence 0.23 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.45 Pain Relevance 0.64
Indole ring substitutions had varying effects on CB 2 and CB 1 binding, but were generally detrimental to agonist activity.
CB 2 Binding (binding) of associated with agonist
14) Confidence 0.22 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18311894 Disease Relevance 0 Pain Relevance 0.30
Among those examined, compound 25 showed potent affinity for cannabinoid receptor 1 (CB1) and receptor 2 (CB2).
CB2 Binding (affinity) of associated with cannabinoid receptor
15) Confidence 0.10 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 18977140 Disease Relevance 0 Pain Relevance 0.37
Molecular modeling studies performed in the context of the CB2 model show that V6.51, L6.52, L6.54, M6.55, L6.59, and T6.62 face into the CB2 binding pocket, further confirming our SCAM results.
CB2 Binding (pocket) of in face
16) Confidence 0.08 Published 2008 Journal Biochemistry Section Abstract Doc Link 19053233 Disease Relevance 0 Pain Relevance 0.25
CBD has low affinity for CB1 or CB2 receptors and could facilitate
CB2 Binding (affinity) of
17) Confidence 0.08 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.64 Pain Relevance 0.36
So too may CB2 receptor ligands and drugs that activate cannabinoid receptors indirectly by augmenting endocannabinoid levels at cannabinoid receptors.
CB2 receptor Binding (ligands) of associated with endocannabinoid and cannabinoid receptor
18) Confidence 0.01 Published 1999 Journal Forsch Komplementarmed Section Abstract Doc Link 10575283 Disease Relevance 0.90 Pain Relevance 0.90

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