INT85145

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.10
Pain Relevance 6.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
spinal 1
smooth muscle 1
paw 1
neurons 1
bladder 1
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 97 100.00 Very High Very High Very High
agonist 121 99.96 Very High Very High Very High
antagonist 70 99.96 Very High Very High Very High
dorsal root ganglion 13 99.80 Very High Very High Very High
Dorsal horn 38 99.72 Very High Very High Very High
intrathecal 22 99.68 Very High Very High Very High
Morphine 10 99.64 Very High Very High Very High
Cannabinoid 111 99.52 Very High Very High Very High
Spinal cord 73 98.80 Very High Very High Very High
Inflammation 63 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 15 99.32 Very High Very High Very High
INFLAMMATION 70 98.64 Very High Very High Very High
Neuropathic Pain 107 97.88 Very High Very High Very High
Overactive Bladder 50 93.68 High High
Pain 155 89.20 High High
Targeted Disruption 14 88.28 High High
Vomiting 11 88.00 High High
Post Operative Pain 66 87.24 High High
Nervous System Injury 6 85.04 High High
Hypersensitivity 63 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, several genes such as BCL6, BTK and CNR2 that may modulate release of eicosanoids [20-22] are also reduced in the ipsilateral DRGs four days after CFA treatment.
Negative_regulation (reduced) of CNR2
1) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.56 Pain Relevance 0.57
This was in accord with the lack of detectable cannabinoid receptor 2 mRNA in (dorsal root ganglion) neurons by in situ hybridization experiments described in the literature.
Negative_regulation (lack) of cannabinoid receptor 2 mRNA in neurons associated with ganglion cysts, dorsal root ganglion and cannabinoid receptor
2) Confidence 0.42 Published 2005 Journal Neuroscience Section Abstract Doc Link 16084654 Disease Relevance 0.33 Pain Relevance 0.69
Dual blockade of CB1 and CB2 receptor signaling prevented the resolution of postoperative allodynia and resulted in persistent over-expression of spinal Glial Fibrillary Acidic Protein (GFAP, an astrocytic marker) and phospho-p38 in astrocytes.
Negative_regulation (blockade) of CB2 receptor in spinal associated with allodynia
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2878341 Disease Relevance 0.76 Pain Relevance 1.06
To test our main hypothesis, we then introduced a dual blockade of CB1 and CB2 receptors during the acute phase of paw incision-induced mechanical allodynia.
Negative_regulation (blockade) of CB2 in paw associated with allodynia
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 1.05 Pain Relevance 1.04
In separate experiments, animals receiving mixed CB1 and CB2 receptor antagonists (day 9 after surgery, n?
Negative_regulation (mixed) of CB2 receptor associated with antagonist
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.05 Pain Relevance 0.22
These effects may be mitigated by co-treatment with adenylyl cyclase inhibitors, like CB2 agonists, to alleviate the neurotoxic effects of oxaliplatin.



Negative_regulation (inhibitors) of CB2 associated with agonist
6) Confidence 0.31 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3003244 Disease Relevance 0 Pain Relevance 0.55
The concerns of global deficit of CB1 and CB2 receptors, in the survival of these mice, can be ameliorated using time-dependent and bladder specific deletion of CB1 and CB2 receptors.


Negative_regulation (deletion) of CB2 in bladder
7) Confidence 0.28 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.43 Pain Relevance 0.35
Lack of a direct effect of CB1/CB2 agonist CP55,940 and the nonselective agonist anandamide on carbachol induced contractions indicated the absence of direct CB mediated functions of isolated detrusor smooth muscle.[34]
Negative_regulation (effect) of CB2 in smooth muscle associated with agonist and overactive bladder
8) Confidence 0.28 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.31 Pain Relevance 0.25
This morphine-induced CB-1 and CB-2 upregulation was dose-dependently attenuated by the intrathecal co-administration of morphine with the glucocorticoid receptor (GR) antagonist RU38486 (0.25, 0.5, or 2 microg).
Negative_regulation (attenuated) of CB-2 associated with antagonist, intrathecal and morphine
9) Confidence 0.02 Published 2005 Journal Brain Res. Section Abstract Doc Link 16150424 Disease Relevance 0 Pain Relevance 1.32
The discovery of this 'endogenous cannabinoid system' has led to the development of selective CB1 and CB2 receptor ligands and fueled renewed interest in the clinical potential of cannabinoids.
Negative_regulation (development) of CB2 receptor associated with cannabinoid
10) Confidence 0.01 Published 1999 Journal Forsch Komplementarmed Section Abstract Doc Link 10575283 Disease Relevance 0.62 Pain Relevance 0.70

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