INT85147

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.29
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
pancreas 4
penis 2
smooth muscle 2
nerve 2
stellate cells 2
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
metalloproteinase 122 99.94 Very High Very High Very High
fibrosis 61 99.60 Very High Very High Very High
Inflammation 38 99.34 Very High Very High Very High
Chronic pancreatitis 15 99.34 Very High Very High Very High
cytokine 15 96.16 Very High Very High Very High
antagonist 8 88.96 High High
Central nervous system 2 76.52 Quite High
Pain 2 59.48 Quite High
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 28 99.96 Very High Very High Very High
Disease 91 99.92 Very High Very High Very High
Targeted Disruption 2 99.88 Very High Very High Very High
Benign Prostatic Hypertrophy 8 99.62 Very High Very High Very High
Fibrosis 45 99.60 Very High Very High Very High
INFLAMMATION 33 99.34 Very High Very High Very High
Pancreatitis 22 99.34 Very High Very High Very High
Injury 13 99.04 Very High Very High Very High
Hypertrophy 1 93.12 High High
Normal Pressure Hydrocephalus 48 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injury to the erect penis is thought to trigger PD by inducing extravasation of fibrin and subsequent synthesis of transforming-growth-factor beta1.
Positive_regulation (inducing) of Gene_expression (synthesis) of transforming-growth-factor beta1 in penis associated with injury and disease
1) Confidence 0.46 Published 2005 Journal Nature clinical practice. Urology Section Abstract Doc Link 16474811 Disease Relevance 1.37 Pain Relevance 0.14
This hypothesis is supported by data in the literature showing enhanced TGFbeta expression in human chronic pancreatitis (2) and development of fibrosis and inflammation in pancreata of transgenic mice overexpressing TGFbeta1 (3).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TGFbeta1 associated with targeted disruption, fibrosis, inflammation and chronic pancreatitis
2) Confidence 0.37 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.86 Pain Relevance 0.37
High doses of lisinopril suppressed the overexpression of TGF-beta1 mRNA measured by reverse-transcription polymerase chain reaction (RT-PCR) and decreased the number of alpha-SMA-positive cells (activated pancreatic stellate cells) in the pancreas.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TGF-beta1 mRNA in pancreas
3) Confidence 0.27 Published 2003 Journal Gastroenterology Section Body Doc Link 12671898 Disease Relevance 0.06 Pain Relevance 0
The conclusion is that candesartan alleviates chronic pancreatitis and fibrosis by suppressing the overexpression of transforming growth factor-beta1, resulting in prevention of activation of pancreatic stellate cells in male WBN/Kob rats.
Positive_regulation (overexpression) of Gene_expression (overexpression) of transforming growth factor-beta1 in stellate cells associated with fibrosis and chronic pancreatitis
4) Confidence 0.22 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.66 Pain Relevance 0.61
The obvious infiltration of CD4- and CD8-positive T cells into the pancreas in the saline group was almost completely prevented by administration of FTY720, which also suppressed overexpression of interferon and transforming growth factor-beta1 mRNA in the pancreas.
Positive_regulation (overexpression) of Gene_expression (overexpression) of transforming growth factor-beta1 mRNA in pancreas
5) Confidence 0.17 Published 2005 Journal Pancreas Section Body Doc Link 15782091 Disease Relevance 0 Pain Relevance 0
The high dose enhanced the expression of angiotensinogen and angiotensin II receptor type 2 mRNA and suppressed the overexpression of transforming growth factor-beta1 mRNA.
Positive_regulation (overexpression) of Gene_expression (overexpression) of transforming growth factor-beta1
6) Confidence 0.16 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.68 Pain Relevance 0.60
However, at the protein level, PDGF-BB impairs typical TGF-beta1 effects such as increased synthesis of collagen (type I) and alpha-SMA.
Positive_regulation (increased) of Gene_expression (synthesis) of TGF-beta1
7) Confidence 0.15 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
CONCLUSION: PDGF-BB augments effects of TGF-beta1 on the mRNA level presumably because of up-regulation of TGF-beta1 synthesis and common signaling pathways of the 2 cytokines.
Positive_regulation (up-regulation) of Gene_expression (synthesis) of TGF-beta1
8) Confidence 0.15 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
Moreover, following obstruction of the bladders of animal models and patients with BPH, there were acute increases in the expression of bFGF (7), the transcription factors, upstream binding factor, c-Jun, and cyclins E and C (8), nerve growth factor (9), N-ras and c-myc (10), and decreased expression of TGF-beta 1 (7).
Positive_regulation (increases) of Gene_expression (expression) of TGF-beta 1 in nerve associated with benign prostatic hypertrophy and nerve growth factor
9) Confidence 0.13 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.74 Pain Relevance 0.09
There appears to be an increase in the CSF concentration of transforming growth factor beta-1 (TGF?
Positive_regulation (increase) of Gene_expression (concentration) of transforming growth factor beta-1
10) Confidence 0.13 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.83 Pain Relevance 0.16
TGF-beta 1, the most potent fibrogenic cytokine, has been reported to increase in pulmonary fibrosis and to be expressed in alveolar epithelial cells in higher levels even in later phase of pulmonary fibrosis.37,38 It was also reported that TGF-beta 1 induces transition of alveolar epithelial cells to mesenchymal/fibroblasts-like cells and MMP-2 expression in those cells,39 possibly suggesting that MMP-2 production in alveolar epithelial cells by TGF-beta 1 may promote pulmonary fibrosis.
Positive_regulation (promote) of Gene_expression (production) of TGF-beta 1 in epithelial cells associated with fibrosis, metalloproteinase, pulmonary fibrosis and cytokine
11) Confidence 0.10 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.72 Pain Relevance 1.05
Pressure increased the expression levels of alpha-smooth muscle actin, alpha(1)(I)-procollagen, and TGF-beta1 in PSCs.
Positive_regulation (increased) of Gene_expression (expression) of TGF-beta1 in smooth muscle
12) Confidence 0.05 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.37 Pain Relevance 0.22

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