INT85149

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.73
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
stellate cells 4
pancreas 4
neutrophil 2
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 27 99.92 Very High Very High Very High
Chronic pancreatitis 25 99.66 Very High Very High Very High
Inflammation 16 96.28 Very High Very High Very High
Sciatic nerve 4 93.48 High High
cytokine 2 93.36 High High
antagonist 4 88.96 High High
IPN 2 78.72 Quite High
dorsal root ganglion 1 75.68 Quite High
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Fibrosis 28 99.92 Very High Very High Very High
Pancreatitis 33 99.66 Very High Very High Very High
INFLAMMATION 11 96.28 Very High Very High Very High
Body Weight 3 94.68 High High
Nervous System Injury 1 80.72 Quite High
Inflammatory Pain 2 78.72 Quite High
Frailty 1 73.32 Quite High
Hypoxia 2 5.00 Very Low Very Low Very Low
Cirrhosis 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1beta and TGF-beta1 expression was also measured.
Negative_regulation (measured) of Gene_expression (expression) of TGF-beta1
1) Confidence 0.42 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10673357 Disease Relevance 0.08 Pain Relevance 0.25
The protective effects were confirmed by an increase in pancreatic weight and decreases in myeloperoxidase activity (an index of neutrophil infiltration), collagen content, transforming growth factor-beta1 expression, and the number of alpha-smooth muscle actin-positive cells (activated pancreatic stellate cells) and ED-1-positive cells (macrophages/monocytes).
Negative_regulation (decreases) of Gene_expression (expression) of transforming growth factor-beta1 in neutrophil
2) Confidence 0.39 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18651219 Disease Relevance 0.83 Pain Relevance 0.48
These results suggest that TGF-beta1 expression may be a trigger of the fibrotic process of chronic pancreatitis in the WBN/Kob rat.
Negative_regulation (trigger) of Gene_expression (expression) of TGF-beta1 associated with fibrosis and chronic pancreatitis
3) Confidence 0.24 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.72 Pain Relevance 0.50
In rats treated with maximal doses of cerulein and TGFbeta antibodies, pancreatic hydroxyproline content and expression of collagens I and III and of TGFbeta1 were significantly reduced.
Negative_regulation (reduced) of Gene_expression (expression) of TGFbeta1
4) Confidence 0.23 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.56 Pain Relevance 0.13
It suppressed the expression of TGF-beta1 mRNA, resulting in the prevention of pancreatic stellate cell activation, which may be involved in the observed protection.
Negative_regulation (suppressed) of Gene_expression (expression) of TGF-beta1 mRNA in stellate cell
5) Confidence 0.22 Published 2003 Journal Gastroenterology Section Body Doc Link 12671898 Disease Relevance 0.05 Pain Relevance 0
High doses of lisinopril suppressed the overexpression of TGF-beta1 mRNA measured by reverse-transcription polymerase chain reaction (RT-PCR) and decreased the number of alpha-SMA-positive cells (activated pancreatic stellate cells) in the pancreas.
Negative_regulation (suppressed) of Gene_expression (overexpression) of TGF-beta1 mRNA in pancreas
6) Confidence 0.22 Published 2003 Journal Gastroenterology Section Body Doc Link 12671898 Disease Relevance 0.06 Pain Relevance 0
However, in the TJ-10-treated rats, the rate of pancreatic fibrosis and the expression of TGF-beta1, FN, alpha-SMA, and type III collagen at 12 and 16 weeks decreased significantly compared to those in the untreated rats.
Negative_regulation (decreased) of Gene_expression (expression) of TGF-beta1 associated with fibrosis
7) Confidence 0.21 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.80 Pain Relevance 0.56
These results suggest that TJ-10 inhibits the pancreatic fibrosis by the suppression of TGF-beta1 expression.
Negative_regulation (suppression) of Gene_expression (expression) of TGF-beta1 associated with fibrosis
8) Confidence 0.20 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.82 Pain Relevance 0.51
The obvious infiltration of CD4- and CD8-positive T cells into the pancreas in the saline group was almost completely prevented by administration of FTY720, which also suppressed overexpression of interferon and transforming growth factor-beta1 mRNA in the pancreas.
Negative_regulation (suppressed) of Gene_expression (overexpression) of transforming growth factor-beta1 mRNA in pancreas
9) Confidence 0.15 Published 2005 Journal Pancreas Section Body Doc Link 15782091 Disease Relevance 0 Pain Relevance 0
The conclusion is that candesartan alleviates chronic pancreatitis and fibrosis by suppressing the overexpression of transforming growth factor-beta1, resulting in prevention of activation of pancreatic stellate cells in male WBN/Kob rats.
Negative_regulation (suppressing) of Gene_expression (overexpression) of transforming growth factor-beta1 in stellate cells associated with fibrosis and chronic pancreatitis
10) Confidence 0.14 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.66 Pain Relevance 0.61
During CIP, serum TGF-beta1 and protein expression of the TGF-beta receptor activin receptor-like kinase-5 (ALK5) were reduced.
Negative_regulation (reduced) of Gene_expression (expression) of TGF-beta1
11) Confidence 0.06 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox